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Metformin / sitagliptin and Nausea: What Users Say

Brand names: Janumet, Janumet XR, Zituvimet, Zituvimet XR

Nausea: mentioned by 10 users (13.2%)

Based on user experiences from 76 Metformin / sitagliptin reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 13.2%
nausea 13.2%
diarrhea 9.2%
dizziness 9.2%
upset stomach 7.9%
rash 5.3%
vomiting 5.3%

Reviews for Metformin / sitagliptin

Commonly mentioned side effects
  • Cha...
  • Taken for 1 to 6 months
  • April 5, 2013

For Type 2 Diabetes "I was diagnosed with type 2 about 6 months ago. I was given Janumet 50/500. It worked great until about a month ago. My sugar in the mornings has risen from the 120s to anywhere up to 190. I feel pretty bad in the mornings and sometimes throughout the day. I've also noticed I sweat at night. I get nauseated a lot and vomit at times. Not sure what my doc will do when my A1C results come back."

4 / 10
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63 Report
  • kno...
  • December 22, 2015

For Type 2 Diabetes "This medicine had bad side effects for me. I have been on this Janumet 50/1000 mg for over one year now. I was taking it one time a day. It made me dizzy, nausea, vomiting after every meal, or whenever I ate something, and night sweats. I used to weigh 230 lbs. at 5'10'' wearing size 16 clothes. Now I weigh 175 lbs. wearing size 12 clothes. I had to get all new clothes. In one week I can lose 10 to 15 lbs. and still losing because I cannot keep my food down. The doctor has me come for a follow-up appointment every 4 months. I informed my doctor of the problem. He was amazed to see the weight loss. I had aged 20 years. My hair had fallen out. My skin was scaly, not moist and smooth. He told me instead of taking the Janumet every day, take it every other day."

1 / 10
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35 Report
  • Sle...
  • April 19, 2016

For Type 2 Diabetes "I was diagnosed with type 2 diabetes in November of 2015. So my doctor did a glucose test which was fasting for me, and my number was 279 on an empty stomach. My A1c, a day or so later, I was at 13.2. My doctor has put me on Janumet 50/500. I was at 203 lbs before the diagnosis, and now, in April 2016, I'm approximately 180 pounds. I was losing weight before the diagnosis due to diabetes, but I guess now since I've been working out for over a month and a half and my eating habits have changed, I guess, and with the medicine, I've dropped more weight. I guess overall my blood sugars are a whole lot better than they were before. A few headaches here and there and nausea, but not so much of that. The medicine is okay, I just don't want to lose any more weight."

9 / 10
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34 Report
  • Lou...
  • November 1, 2011

For Type 2 Diabetes "I have just recently changed from Metformin to Janumet 50 mg/500 mg, one tablet twice daily with food, and have suffered from headaches, nausea, and some dizziness. I have seen two Drs. One advised staying on Metformin as it has maintained good results for many years, and Janumet is still a more recent medicine in Australia. The other Dr advised that Janumet will control my levels a lot better and decrease the situation of gaining weight, even though in the early stage I have some side effects. I intend to continue with Janumet for another month, hoping for improvement, aged 70."

4 / 10
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44 Report
  • Anonymous
  • September 7, 2009

For Type 2 Diabetes "I had bad side effects from this medicine. I had nausea, headache, and dizziness almost daily since taking Janumet. Thinking my body would adjust, I kept taking it for about 6 months. Since I stopped it 2 weeks ago, the nausea, headache, and dizziness have stopped. I will have to get 'real' with myself and do diet and exercise."

1 / 10
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42 Report

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  • bit...
  • Taken for 1 to 6 months
  • June 7, 2019

For Type 2 Diabetes "Janumet XR is very effective in lowering sugar levels. I have been a type 2 diabetic since 2009. I am 49 years old and had noticed my sugar level going up with my old medicine, Glucophage 500 mg. I went for a full check-up, and my doctor told me to change to Janumet XR, and my fasting sugar level went down, and two hours after a meal to normal. I take two a day, 50 mg/1000. I have side effects: nausea, not sleeping well, and I eat much less than I used to. I think I feel this because I take both pills at the same time in the morning. I will try to take one in the morning and one at night and see if the side effects go away."

7 / 10
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17 Report
  • bev...
  • May 28, 2009

For Type 2 Diabetes "I have had nausea, headache, and dizziness almost daily since taking Janumet. Thinking my body would adjust, I kept taking it for about 6 months. Since I've been off of it for 2 weeks, the nausea, headache, and dizziness have stopped. I will have to get 'real' with myself and do diet and exercise."

5 / 10
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21 Report
  • Smi...
  • Taken for less than 1 month
  • May 3, 2018

For Type 2 Diabetes "Just started this medication as prescribed by my doctor. It may work for some, but for myself just after one week, I have horrible side effects of upset stomach, nausea, severe muscle ache, and night sweats. I felt like I was doing chemotherapy all over again. Be very careful with this medication."

1 / 10
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13 Report
  • Dia...
  • Taken for 1 to 6 months
  • June 1, 2024

For Type 2 Diabetes "The first week was awful, I have acid reflux and it combined and made it terrible since I was also doing a diet change. Once that was over, however, I didn't have any more symptoms. The first week I was very nauseous, a little light-headed, and a bit more tired than usual. My insurance covered it twice, but after that has refused. I did lose 15+ pounds, so if you really wanna lose weight, this pill would help quite a bit, lol. Overall, I feel comfortable with it, I really wish my insurance would let me keep taking it."

10 / 10
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  • Gol...
  • Taken for less than 1 month
  • August 29, 2020

For Type 2 Diabetes "I just started Janumet, and the nausea and the stomach pains are horrible. I can't sleep due to indigestion or whatever this sick feeling is. Has anyone else experienced this?"

2 / 10
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9 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.