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Metformin / Sitagliptin Dosage

Medically reviewed by Drugs.com. Last updated on Feb 23, 2023.

Applies to the following strengths: 500 mg-50 mg; 1000 mg-50 mg; 1000 mg-100 mg

Usual Adult Dose for Diabetes Type 2

Dose should be individualized based on patient's current regimen, effectiveness, and tolerability.

IMMEDIATE-RELEASE:

EXTENDED-RELEASE:
TITRATE metformin dose slowly to reduce gastrointestinal side effects; titrate combination dose to achieve optimal glycemic control
MAXIMUM: Sitagliptin 100 mg/day; Metformin 2000 mg/day

Comments:

Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Renal Dose Adjustments

Mild renal impairment (eGFR greater than 45 mL/min/1.73 m2): No dose adjustments recommended
Moderate renal impairment (eGFR 30 to 45 mL/min/1.73 m2): Initiating therapy is not recommended
Severe renal impairment (eGFR less than 30 mL/min/1.73 m2): Use is contraindicated

If eGFR falls below 30 mL/min/1.73 m2 during therapy: Discontinue therapy
If eGFR falls below 45 mL/min/1.73 m2 during therapy: Assess risks versus benefit of continued therapy AND limit the sitagliptin component to 50 mg/day

IODINATED CONTRAST PROCEDURE:

Liver Dose Adjustments

Hepatic impairment: Use not recommended

IODINATED CONTRAST PROCEDURE:

Dose Adjustments

Elderly: Dose selection should be cautious usually starting at the low end of the dosing range; assess renal function frequently

Radiological Studies with Contrast:


Heart Failure:

Precautions

US BOXED WARNINGS: LACTIC ACIDOSIS


CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Contraindicated in patients with moderate to severe renal dysfunction
Hemodialysis:

Peritoneal dialysis: Data not available

Other Comments

Administration advice:


General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.