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Medroxyprogesterone and Depression: What Users Say (Page 5)

Brand names: Provera, Depo Provera, depo-subQ provera 104

Reviews for Medroxyprogesterone

Commonly mentioned side effects
  • anx...
  • Taken for less than 1 month
  • May 2, 2015

For Abnormal Uterine Bleeding "I've been having constant bleeding or just huge blood clots since I got the shot 2 weeks ago. Also, it's caused me the worst anxiety and depression I've ever experienced in my life. I would not recommend this to anyone ever..."

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  • Thi...
  • February 3, 2016

For Abnormal Uterine Bleeding "I have been bleeding for 5 months now. I only got one shot, and ever since I didn't get the second, it's been nonstop heavy bleeding for two months. All I can ask is when will the bleeding, depression, and headaches stop."

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  • Ran...
  • Taken for 1 to 6 months
  • November 10, 2019

For Abnormal Uterine Bleeding "I got the Depo shot, and I have been bleeding nonstop! I am bleeding very heavily and through overnight pads. I have bought pads every week for two months. I have also gone through mood swings where I am very depressed and then very angry. I will never take the Depo shot again."

1 / 10
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Frequently asked questions

  • Ray...
  • January 26, 2020

For Endometriosis "I was put on the Depo shot a year ago to help treat my extremely painful periods. It stopped my menstrual cycle, so for a year I've been able to avoid the terrible pain I was in every month. However, the side effects have been awful. My whole face is covered in painful acne, and I didn't have this problem before the shot. I've experienced terrible headaches, I've spotted the whole year I've been on it, and had other discharge as well. My anxiety is through the roof, and it has worsened my depression. My advice is to stay far away from the shot if you can avoid it. I can say it's been nice not having the terrible pain endometriosis was causing me every month, but the other side effects are almost just as bad. I just had my last shot and will never take it again."

2 / 10
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  • All...
  • Taken for 1 to 2 years
  • July 24, 2017

For Birth Control "I am so thankful for this birth control. I switched from the pill to Depo because the pills gave me horrible anxiety and depression. Immediately after I switched, I was myself again. After two doses, my periods stopped. I know birth control affects everyone differently, but I have had no negative side effects at all. My only complaint is after every injection, I would get a headache for a couple of days. I'm 21, and I just hit the two-year mark, and my doctor recommended that I switch to a different BC this month, and I'm so sad and nervous... I am worried about getting the negative side effects of a new BC after being worry-free and comfortable for 2 years."

9 / 10
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  • Can...
  • January 10, 2020

For Birth Control "Depo ruined my life. I had anxiety and depression to begin with, but it was well-managed with antidepressants. I went on Depo, and it made me go from 118 lbs to 150 lbs within 3 months. I lost all motivation, sleeping 16-18 hours a day, only getting up for work and working out as I was disgusted by my body. While on it, I had some bizarre suicidal ideation that subsided after the 3 months. I only had one injection of Depo. It’s been over a year since I was on it, and the doctor told me that it’s possible that Depo made permanent changes to my metabolism, as I have been unable to lose the weight despite rigorous exercise (~12-14 hours/week, I am an ex-varsity athlete and am no stranger to intense workouts) and, if anything, a LESSER caloric diet than previous to the Depo. I have been unable to find a medication that is effective at treating my depression. This should NEVER be prescribed to anyone, especially someone with a mental health history."

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  • Can...
  • January 10, 2020

For Birth Control "Depo ruined my life. I had anxiety and depression to begin with, but it was well-managed with antidepressants. I went on Depo, and it made me go from 118 lbs to 150 lbs within 3 months. I lost all motivation, sleeping 16-18 hours a day, only getting up for work and working out as I was disgusted by my body. While on it, I had some bizarre suicidal ideation that subsided after the 3 months. I only had one injection of Depo. It’s been over a year since I was on it, and the doctor told me that it’s possible that Depo made permanent changes to my metabolism, as I have been unable to lose the weight despite rigorous exercise (~12-14 hours/week, I am an ex-varsity athlete and am no stranger to intense workouts) and, if anything, a LESSER caloric diet than previous to the Depo. I have been unable to find a medication that is effective at treating my depression. This should NEVER be prescribed to anyone, especially someone with a mental health history."

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  • Ari...
  • Taken for 1 to 6 months
  • November 7, 2019

For Abnormal Uterine Bleeding "Stay away from Depo. I get Depo in Sep 10, 9 days before my period. I didn’t have my period for two months. Now I have been bleeding for 8 days. I expelled a clot that looked like placenta. I was super scared! My depression is getting worse. I’m always so mad with my husband, and I have less patience with my baby! I feel so bad! I gained about 10 pounds in less than two months! I have never felt pain in my periods, and now I feel like I’m having a baby."

4 / 10
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  • kay...
  • Taken for 6 months to 1 year
  • January 7, 2015

For Birth Control "Effective and not disappointed. After the first 3 weeks on the shot, I had a heavy period for almost 20 days, but after that, absolutely no period, no cramping, spotting, nothing! Some weight gain, but I'm successfully burning that off. The only downside is the depression and anxiety, but those are occasional. They only happen within the first couple of weeks of taking the shot, and I just got my third dose. Love it, but it's not for everybody!"

10 / 10
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  • 123...
  • Taken for 2 to 5 years
  • December 8, 2019

For Birth Control "I was on Depo for almost 4 years (age 15-19). I never really realized the side effects that it had created until getting off of it and looking back. Although Depo was really beneficial in some ways, it also hurt me in other ways. For one, I became very depressed and sluggish, and I was just sick all the time and didn’t know why. I was never sad, just out of energy always. I also gained so much weight, which I knew going in would probably happen. However, this medicine helped me out a lot too. Before I began Depo, my period was so, so heavy and very painful. After using Depo, I stopped having my period and the cramps went away, along with getting sick from my period. It also helped so much with my hormones and mood swings, I was less grouchy all around. If you’re thinking about using this drug, just weigh your options and remember the results are different for everyone, but it’s definitely an option I think people with painful periods should look into."

8 / 10
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  • Sad...
  • November 12, 2015

For Abnormal Uterine Bleeding "My experience with Depo has been terrible. I have gotten a total of 3 shots, so it's been nine months since I first got the shot. I have not stopped bleeding since the first day I got it. I constantly have to worry about wearing a pad and tampon because my period has become so heavy that I have to wear both. Not only have I experienced having my period every single day, but I have to pay a $25 copay every time I go get the shot. I'm also cranky and have zero sex drive. This is destroying my relationship with my boyfriend. I also feel depressed all the time. My primary care physician finally told me to go to an OB/GYN, and the OB put me on a high-dose birth control pill. I start that on Sunday and cannot wait for this feeling to go away."

2 / 10
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  • Nic...
  • Taken for 5 to 10 years
  • October 25, 2016

For Birth Control "I have been on Depo since I was 13. I am about to be 21 now. I never spotted, and after I got my shot, my periods were officially gone. I was actually recommended to try Depo because my friend was on the pills and got prego and decided to do the shot and never got pregnant. But now that I'm at the age of possibly wanting a child, I don't know how long it will take to conceive. I did suffer from depression after the shot, but I never gained weight. I actually did the opposite. I lost 50 lbs the first year. Spotting during your first shot is actually normal, the shot is trying to force the periods to stop, which will cause cramps, so it's normal! I just got lucky. I definitely recommend this."

9 / 10
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  • mar...
  • July 23, 2019

For Birth Control "I’m 18, and I took my shot in Nov. 2018. My gynecologist told me I may lose my period, but gave me no info about the side effects. A month after the shot, I started feeling depressed. I lost my period, and after experiencing a change in mood swings, my body, and my period, I decided to not get the second shot of Depo, which was scheduled in Feb. 2019. My period didn’t come back naturally, so I went to my gyno in Apr. They gave me progesterone pills to take to start my period. I took the pills for 10 days, and my period only lasted a day. 3 days later, I felt itching down there. It’s not an infection or an ST, or anything they can determine through biopsy or a culture. I’ve also had a month-long period. My last visit, I was told it may have to do with hormone imbalance. So, I was given a new birth control pill, Sprintec, to regulate my period and hopefully end the itching I’ve had for months. I fully believe all of this was caused by the Depo shot, and my body has not been the same since."

1 / 10
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  • And...
  • Taken for 1 to 6 months
  • October 30, 2019

For Birth Control "I got this Depo Provera shot for birth control at my 6 weeks postpartum appointment. I didn’t read any side effects, which is my fault, I should have done my own research. The first month I bled for 3 weeks straight, heavy flow. I noticed my mood was all over the place, and depression was at a high for me. I gained about 15 pounds just being on this for 3 months. My knees hurt when I sit on the floor, and that has never happened before. My anxiety is through the roof. I’m always on edge and have lost so much sleep. My sex drive is so dead right now, it hurts to have sex. Literally, it hurts. I only did one round of this shot, and I won’t be getting a second one. Please do research and talk to your doctor about this shot before getting it!"

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  • sar...
  • June 23, 2018

For Endometriosis "I hate this shot, it ruined my life. I had very severe side effects that started the day after I got the shot and have not stopped. My old provider refused to admit that my pain was due to the shot. I have constant cramping, constant bleeding, migraines, my hair is falling out, my depression is worse than ever, increased anxiety, insomnia, muscle soreness, joint pain, and mood swings. I was told that this shot would stop my period, it did not, it just made my period last for 10 months, and it is still going. I will never get this shot again, and I do not recommend this shot for anyone."

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  • Laz...
  • November 16, 2016

For Birth Control "I stopped taking Depo because of the depression and lack of sex drive it was causing me. I had the spotting in the beginning for about 3 months, and after the second shot, I felt dizzy all the time. I'm in the process of getting it out of my system, and it's an absolute nightmare. Since skipping my last shot, I've had heavy spotting and headaches almost every day. I can't sleep through the night at all, and I've been having an increase in nightmares that I'm certain is related to the birth control. My dreams were never this bad before. My hair also started thinning badly, and I had to cut about a foot of it off. I loved my long hair. DO NOT get this shot. The side effects are not worth the risk."

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  • Anonymous
  • December 12, 2009

"I have been on Depo Provera since April 2009, and now it's December 2009. I had an okay experience. The best thing about it was that it stopped my period right away, which was really nice for sports. I did not gain weight, have nausea, or sore breasts, but it really lowered my sex drive, and it made me drier than normal for the first few months. I think it caused some hair loss, but not too much. My boyfriend said I was really moody on it, which has really interfered with our relationship. (I think I had some depression because of that). I am switching to the NuvaRing in two weeks, and hopefully, I will be less moody. All in all, Depo Provera was okay. I would recommend trying it at least to see how you react to it."

7 / 10
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  • SJe...
  • March 29, 2016

For Birth Control "Horrible form of birth control. Convenient, yes, but bled continuously while I was on it. Gave me severe depression when I have never had any depression before. Gained weight steadily with no change in diet, so Depo is the cause. After 3 doses and no improvement in side effects, I stopped this nightmare."

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  • eas...
  • May 1, 2013

For Birth Control "I have been on the shot for two years now, and overall, it's been great. I couldn't remember to take a pill every day, so my doctor suggested the Depo Shot. When I first got the shot, I bled for almost two months straight. After that, nothing, besides some spotting when I'm up for my next shot. However, I have noticed I've lost some of my hair, my depression worsened, and I experience major mood swings from time to time; I didn't gain any weight. My doctor just notified me of the risk of osteoporosis and suggested taking 1000 mg of calcium and 400-800 mg of vitamin D per day. This is suggested after receiving the shot for 2+ years. Either way, I wish I knew this sooner. I would have been taking those vitamins since day one."

8 / 10
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  • Bel...
  • Taken for 1 to 6 months
  • August 26, 2016

For Birth Control "I just had my 3rd shot, and I'm very happy with it. Before I got on the shot, I had tried several different pills. They all made me have mood swings and depression, and I felt tired all the time. My doctor talked me into trying the Depo shot, and it has been amazing. I feel full of energy, and I haven't had any mood swings, and the best thing is I haven't had a period since!!!! The only side effect that I don't like is the weight gain. I have been working out like crazy to prevent the weight gain, which I haven't gained any weight, but I can't lose any. So basically, I'm working out just to stay the same. This sucks, but if this is the worst of the side effects for me, then I can deal with that."

9 / 10
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  • Kay...
  • February 1, 2016

For Birth Control "I am only limited to a few options because I am on seizure meds. Before the meds, I responded very well to the pill! This is my 3rd Depo Provera shot, and I feel like a completely different person for the worse. I have no sex drive, I have panic attacks daily, my hair started falling out, I literally sit in my room depressed when I'm not working, my vision changed, I have upper back pain and neck pain, I am tired all the time. I miss the girl I used to be before this injection. My blood work is perfect, I've had several tests done. This drug is a poison, and I can't wait until March for me to decline to never get it again!"

1 / 10
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  • Jac...
  • Taken for 1 to 6 months
  • January 5, 2019

For Birth Control "The Depo shot is the worst birth control anyone can take. DO NOT TAKE!!!! When I first got my shot, I immediately started feeling sick and was in and out of the hospital for two weeks due to throwing up everything I ate and not being able to function. I wish someone would’ve told me about the shot. However, it didn’t make me bleed for months like it does a lot of girls, but the feeling that the shot caused me and the depression. I wouldn’t wish it on my worst enemy. Do yourself a favor and choose a different form of birth control, PLEASE."

1 / 10
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  • Ley...
  • Taken for 1 to 6 months
  • October 25, 2021

For Birth Control "Please read!! I got Depo Provera 2 months after I had my daughter for birth control. Worse decision ever. I know everyone reacts differently to a drug, but trust me when I say stay away from this. I got only one injection that lasts three months, but that was enough to destroy my mental health. It was horrible, made me gain 10 pounds in just three months, gave me the worst depression and anxiety of my life. Two years later and still no recovery, my doctor had to put me on antidepressants. Please read the reviews before you get the injection because after you get it, it will be too late!! This drug should be out of the market. I give it one star. It is awful, don’t do it."

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  • Car...
  • Taken for 1 to 6 months
  • May 31, 2012

For Birth Control "I thought this would be a great option. Well, I was definitely wrong. I was on the patch when my parents found out I was on birth control, subsequently, they took the rest away. I went to my school clinic and received the shot the same day for free. I did not have to worry about prescriptions or about hiding my patches anymore, which was great and all. Until the first week in, I felt fine, then something just dramatically changed with me. I had no sex drive, pain during intercourse, 10 pounds of weight gain for the first two months and 5 for the third month, and spotting daily. I also had terrible mood swings and migraines. I felt depressed from the weight gain, I wasn't me anymore."

3 / 10
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  • Ano...
  • Taken for 6 months to 1 year
  • October 17, 2015

For Birth Control "I started the Depo shot a year ago. Originally, I bled for 3 weeks with a few days off. After my second shot, I bled for 2 weeks and had 2 weeks off of my period. Then, once my period started up again, it never stopped. So, I've been bleeding since the end of January, which makes almost 9 months that I've been bleeding/spotting with not even one day off. There were times when it stopped for a few hours, but I guess if it came right back, it never actually stopped. I didn't gain weight, I've struggled with mild depression, anxiety, poor appetite, fatigue, lots of nausea, and abdominal pain. My last shot was at the end of March. I'm getting the pill tomorrow to help regulate my hormones. I'm afraid of all birth control now, but I hope this works."

2 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.