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Tresiba and Fatigue: What Users Say

Fatigue: mentioned by 7 users (4.6%)

Based on user experiences from 152 Tresiba reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 11.8%
weight gain 11.8%
tiredness 7.9%
nausea 7.2%
dizziness 6.6%
bloating 5.9%
diarrhea 5.9%
itching 5.3%
fatigue 4.6%
flu-like symptoms 4.6%

Reviews for Tresiba

Commonly mentioned side effects
  • Can...
  • October 11, 2018

For Diabetes, Type 1 "I have been a type 1 diabetic for 29 years...since 1989. I have been on nearly every insulin (think pig or bovine). My endo recommended the switch to Tresiba because it was “the poor man’s pump” nearly two years ago. I was made to believe I was ill in other ways (PCP and many tests that were negative). My stomach hasn’t been right in two years. I watch my caloric intake like a hawk! I have gained weight, lost energy, and felt sicker than I have ever felt. I went from running half marathons to walking a few miles per week...this is THE connection. I appreciate those that validate your response to this medication. It may be different than others, but it has had a drastic negative effect on me."

4 / 10
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  • Lib...
  • May 1, 2017

For Diabetes, Type 1 "My endo insisted I switch from Lantus to Tresiba. I was quite stable on Lantus and Humalog for over 15 years, but she said it was better. I've been a diabetic for almost 30 years, and so I was very hesitant to switch. I should have listened to myself. The first 3 weeks were okay, but not better. Then I started feeling breathless and fatigued. It took me a while to realize it was the Tresiba. I switched back to Lantus a week ago, and I am already feeling better. No more breathlessness or fatigue. My blood sugars were worse on Tresiba, so it will take a bit to straighten out my A1C. I really should have listened to my gut. Just because it's new doesn't mean it's better."

1 / 10
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22 Report
  • Kat...
  • Taken for 6 months to 1 year
  • July 7, 2024

For Type 2 Diabetes "I have been a diabetic for 15 years, during which time there were periods I was diet-only controlled, other times on oral meds. Last year, while on oral meds, I began to experience blood sugars of 500-700+ daily. My doctor changed dosage, added additional oral meds, and started me on Lantus, but I remained uncontrolled, leading to hospitalizations and numerous ER trips for IV insulin. I switched endocrinologists and was prescribed Tresiba along with the lowest dose of Ozempic. Within 4 weeks, my blood sugars were stable. I experienced some headaches, fatigue, and dizziness in the first few weeks, which I contributed more to my body adjusting to the blood sugar dropping, but it could have been due to Tresiba. Tresiba was a lifesaver for me! My A1C is now 5.7, and I have had no hospitalizations or ER trips since I started it 8 months ago."

10 / 10
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3 Report

Frequently asked questions

  • seb...
  • Taken for 2 to 5 years
  • March 11, 2022

For Type 2 Diabetes "I was diagnosed with type 2 diabetes about 10 years ago, found through routine bloodwork. I was immediately put on mealtime insulin, but we discovered very quickly that I am extremely sensitive to insulin. About 4-5 years ago, I was put on Tresiba. I was only using 5 units a day, but went up to about 8 about 3 weeks ago. I've been feeling terrible lately, so I thought back and realized very slowly I was getting progressively worse and worse with the way I felt. My side effects have been: some form of a headache every night from slight to debilitating; horrible joint pain, mainly in my fingers and toes; itchy, congested ears; hoarse voice; blurry bad vision; depression; constant fatigue; zero libido (I'm a female); all over the place readings for no apparent reason; high fasting numbers; and more. Also, my A1C over the years keeps creeping up and up and up. I just switched back to a sulfonylurea, I'm so thankful! I wanted to share to let people know these things aren't just in their head!"

2 / 10
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  • Ver...
  • Taken for 6 months to 1 year
  • January 26, 2023

For Diabetes, Type 1 "I have Type 1 diabetes and found Tresiba did not work as effectively as Levemir. My glucose levels stayed in the 300 range even after a dosage change. I experienced sore muscles, weight gain, a general sick feeling, and extreme fatigue. I do not recommend this medication for Type 1 diabetes."

1 / 10
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5 Report

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  • Pol...
  • May 7, 2021

For Diabetes, Type 1 "I'm from Poland. I took Tresiba in October 2019. My sugars were not too bad. But my sense of well-being was terrible. I had shortness of breath, headache, and dizziness, stomach pain on the right side, fatigue, sadness. After 2 months, I returned to Levemir. In April 2020, I started to feel terrible, it turned out that I now have celiac disease and histamine intolerance. My doctor looked at me as if I was crazy as I told him that I felt terrible after Tresiba. I have the impression that Tresiba led to celiac disease."

1 / 10
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4 Report
  • Beb...
  • November 15, 2019

For Diabetes, Type 1 "Horrible adrenaline surges/rushes since switching to Tresiba. Anxiety, fatigue, brain fog, depression all within a week."

1 / 10
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20 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.