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User Reviews for Zyclara

Condition Avg. Rating Reviews Compare
42 reviews 17 medications
Condylomata Acuminata  
2 reviews 6 medications

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Zyclara

Justin · Taken for 1 to 6 months July 24, 2019

For Keratosis: “I have had a recurring actinic keratosis on my temple( beside my eye) on and off for several years, plus several eczema-like lesions on my cheeks, neck and behind my ears. I have gone through the recommended 6-week Zyclara treatment and my skin is much better, almost completely clear, with just a few little areas remaining for which my dermatologist has recommended a further 'cycle' of 6 weeks. which will start in the next few days. I had the usual unsightly red scabs on one side and then the other. They were rather sore and itchy, but not unbearably so. Many friends have commented on how much better my skin looks, which is encouraging! I also have a compromised immune system, due to a chronic leukaemia, but no obvious side effects. I live in Spain, so have had to be careful about further sun exposure.”

8 / 10
Dakota123 March 19, 2019

For Keratosis: “I'm on the second round of applying Zyclara, week two after using it for 2 weeks on and 2 weeks off. The first round I had no side effects and very minimal skin changes until day 13. I saw my dermatologist on day 15 and she said she would consider it a mild to moderate reaction. I had a crusty place on the bottom side of my nose, and a pimple like place on the skin next to my nose and one on my nose. I'm on day 8 of round 2 and noticed a pimple like place on the skin next to my nose in the same place as before. I was so scared to try this lotion after seeing the pictures of what could happen. I had MOH's surgery on my nose last summer and would like to avoid having that again if at all possible. I had good results, very minimal scarring and it's not noticeable now but the whole process of the surgery just grossed me out. My doctor wants me to apply the Zyclara for 3 two week on and two weeks off sessions. I hope this does the trick, it seems to be working.”

8 / 10
Sybs February 10, 2019

“I have Basal cell cancer and had Multiple MOHs surgeries in past. Been using zyclara daily everywhere on face but upper lip for 10 days now. Doctor has me on a 2 week on, 2 week off and 2 weeks on again schedule. So far I have had no reaction to cream. Maybe that’s a blessing but concerned that maybe drug is bad?”

1 / 10

Frequently asked questions

Scott876123 December 31, 2013

For Keratosis: “Have finished my first two week application and am about to start the second. I'm a 44 yo fair skinned male who rarely wore sunscreen as a kid and had my share of sunburns. Had a few Actinic Keratosis spots that kept coming back so doc put me on Zyclara for my forehead and cheeks. After reading the horror stories I was absolutely dreading it. To my delight the side effects were not bad at all, and I just had 4-5 spots flare up that looked like acne. I never post to things like this, but I hope some see this and know that not all people have the horrible effects of it. I can certainly sympathize with the ones who do though.”

8 / 10
Max Moore January 23, 2014

For Keratosis: “I used Zyclara for 2 months, applying it for a week and then taking a week off. I have to say, it does work. I had many pre-cancer spots on my forehead, face and shoulders, that stayed there for years, despite annual freezing treatments. Zyclara cleared up these spots, and they seem to be gone permanently. As for side effects, it was a terrible experience, but only for the first couple of weeks. Basically, the first week of treatment was Hell, the second week was Heck, and the third and fourth weeks were Gosh and Golly. So, only the first week of treatment was painful. For that first week of treatment, it was like being hit with both a body-aching flu and a sleeping sickness at the same time.”

9 / 10
Anonymous · Taken for 1 to 6 months February 13, 2013

For Keratosis: “I am on week 5. I first used it on my arms with no result. So I decided to do my forehead. A few spots came out. Now I'm doing my chest area...major sun damage! I'm not going to lie, it itches and burns. If all these spots are pre-cancer cells, then its definitely worth a few weeks of pain and discomfort! I just told my co-workers what I was doing so I didn't feel the need to "cover-up". Actually feels better not to have clothes rub on it. I take Advil for the pain. If only I could go back in time and tell myself to get out of the tanning beds, its not worth it!”

10 / 10
Sdollar · Taken for 5 to 10 years December 11, 2018

For Keratosis: “58 yo female, fair but I do tan. First basal cell at 27; MOHs surgery x2 . Also squamous cells and ##AKs & SKs frozen every 6 months. Aldara too intense. Been using Zyclara every winter for YEARS. Haven’t been brave enough to do my face but need to. Takes 5-7 days to start seeing effect; usually stop around day 10. It’s like trying to stop a speeding train - continues to intensify for several days after stopping. Oozy, itchy just like everybody says but it works! Flu-like symptoms because Zyclara stimulates an immune response. NOT topical chemo. I do one area at a time and rotate - back or chest or arms or legs. Stimulated lymph nodes are a normal immune response. If I feel “flu” I hold off for 2 days. Believe me the train keeps running but the symptoms reside. Every other day from there then it’s time to stop. I love that it flares spots I can’t see and heals better than burn/scrape or freeze. It’s a drag but I’m glad to have the option.”

10 / 10

More FAQ

Sunburn girl November 14, 2013

For Keratosis: “I feel much better after reading the experiences of others, which are so like mine. I'm a 44 yr old Florida native who spent way too many hours in the sun. I had my first basal cell excised at age 26; several more removed through MOHs, and Actinic Keratosiss "frozen" off, since. I tried Carac on my chest last year with little response. Now on day 13 of using Zyclara on my chest and shoulders and -- wow. By day 2, I had spots appear & the number of red, swollen, itchy lesions has multiplied every day since. I do NOT think I would be brave enough to use Zyclara on my face, given my significant (and unsightly) response. It IS uncomfortable, but hopefully worth it. Fabric-covered cool packs, ibuprofen and Neutrogena Excema Essentials cream has helped.”

9 / 10
greg123 May 27, 2011

For Keratosis: “I am on the last three days of the 2nd two week application step. I'm using on my forehead and cheeks and what a mess. I'm covered in red itchy weeping spots and blotches. I have nausea but that's the price you pay for baking in the sun as a kid. I'm 62. This medicine seems to work and if you don't mind looking like your face caught fire for a few weeks to maybe save your life then go for it. ”

10 / 10
1st Timer May 29, 2010

For Keratosis: “I have used Zyclara for 10 days I have all of the side effects except for the lymphadenopathy. The side effects began on the 8th day of usage. I am taking myself off the drug for at least two days and will stay on the schedule of 2 weeks of medication, 2 weeks off, and 2 weeks back on. I was warned by my doctor that I might need a rest from the medication and I was thinking it was because of the sores it creates, but it is that and everything else. ”

5 / 10
ecsecs1949 June 24, 2013

For Keratosis: “I am 64 and have a lot of what my Dr. describes as pre-cancerous areas. I have just completed my 2nd two regime, the first having been done a couple of years earlier. I did my head and the left side of my face about half way down my cheek-only wanted to look half horrible. I took more than two weeks between the 1st and 2nd cycle both times to give the areas more time to heal. Don't know the significance of this delay. I got the eruptions to the point that I called my Dr who said there was no problem and showed photos I took during the treatment when I next visited my Dr.- all normal. I did feel fluey, sore all over, and verging on sick to my stomach, a 200 mg IBU solved the problem-its a real miracle for me.”

8 / 10
alsiii February 16, 2011

For Keratosis: “I've been using Zyclara for 7 days. I have loss of appetite, I've lost 5 lbs already. I feel a little nausea, fatigue, and pain and itching. All of which make me feel like hibernating, but I can't, I have to work! People are beginning to question the skin eruptions and weight loss. I hope this will be worth it. I've tried all other forms of removing basal and squamous from my body including Mohse surgery, but they always reappear over the scar tissue. I have not tried radiation. I hope that Zyclara is going to be the answer for me.”

10 / 10
Anonymous January 19, 2012

For Keratosis: “I took Zyclara for the first time a year ago at the age of 34 after my doctor froze off 3 actinic keratosis. Actinic keratosis on my nose is back, also I still have red spots where lesions were during the initial treatment. Doctor says I need another round to finish off the damage and as a last best hope to avoid having to surgically remove the spot on my nose. I have fair skin and tons of sun damage (including 2nd degree burns over 20% of my body). My doctor initially recommended that I take 2 months off for the treatment, this time I will take her advice! I found the treatment too intense to work through due to pain and fatigue. Moisturizing the area with petroleum jelly and a topical anesthetic and antimicrobial (neosporin or polysporin) helped a lot!”

8 / 10
Anonymous November 23, 2015

For Keratosis: “I am a female in my late 60s, and on day 13 of the 1st round of 14. After tomorrow, I will be off 2 weeks, and back on for 2 weeks. I am using it on my temples and forehead. Luckily, I have a lot of hair to cover the red spots that have surfaced on my temples. However, I have had NO flu like symptoms, NO fatigue, NO stomach problems. Nothing.....just a bunch of ugly red spots”

8 / 10
Carol Ann 2 August 9, 2011

For Keratosis: “I will give this medicine a higher rating perhaps when I finish the treatment. At this point (day 5 in the first round), I have muscle pain, lethargy and a dull headache. I feel like I have a mild virus. I have eruptions - red, itchy bumps - but that doesn't bother me as it means the medicines is working and that's exactly what I want. It will be worth it to be rid of precancerous cells on my forehead and hands. But there are some side effects and they seem to vary person to person. For me they are manageable.”

8 / 10
Esteban Yan February 13, 2016

For Keratosis: “I am on day 11 of a 14 day cycle and the first week I experienced flu like symptoms i.e., achy muscles, fatigue & head aches. My only side effect now is a slight headache. I am using Zyclara on my face (temples, forehead and cheek) and my face is looking pretty ugly right now. It looks like an awful outbreak of acne and is very raw. I have more than a few scabs and a lot of redness where I have been applying the cream. It is very itchy and tender and to be honest, while I am still in the middle of all of this, I have questioned whether I would do it again. I guess it would be better to answer that in a couple of weeks. I have wanted to stop using it but it is like swimming half way across a lake. I think I will be happy in a couple of weeks”

7 / 10
Browniebaker · Taken for less than 1 month September 21, 2016

For Keratosis: “Had been on the Zyclara, putting it on my chest only, for 10 days when I experienced high fever, chills, shortness of breath, nausea, sore throat, aching joints, headache, numbness in my fingers, metallic taste in my mouth, dry mouth and extremely tired. Dr. told me to stop. Symptoms still continue after 5 days off. He refuses to say it's from the cream, but I am never sick and only became sick after being on the cream. Hopefully, the cream will have done it's job and after the redness and spots disappear, I will have a clear chest again. It is a chemotherapy cream, so no wonder there will be side effects. Stupid doctor for not taking responsibility for this!!!!”

8 / 10
Facetime April 20, 2013

For Keratosis: “I just finished the second phase of two weeks on Zyclara. It is doing its job for sure. Alot of open sores at the surface. Doctor put me on antibiotics as I have some infection going on. Also, using a antibiotic topical cream to help. It is painful but worth the time going through this as I have heard good results. I have had the Mohls surgery and also Efudex. Hope this clears it up for good.”

9 / 10
Ren1313 · Taken for 1 to 6 months May 5, 2015

For Keratosis: “I noticed a bothersome "pimple" that never healed on my back a few yrs ago. After biopsy the dermatologist diagnosed it as basal cell. She lasered it twice for removal. I noticed another spot on my left shoulder, and 3 more spots on my chest 6 mos ago. I have no insurance so Dr suggested Zyclara cream. My first session was 1 week on, 1 week off, then another on and another off. It brought out more spots (which shocked me) in my cleavage and upper chest area. She put me on a second session of 2 weeks on, 1 week off, 2 weeks on. I just finished that session, and other than the new lesions that appeared from the cream, the original spots are almost gone. I have had no apparent negative side effects while using this cream.”

7 / 10
KC · Taken for 1 to 6 months July 6, 2018

For Keratosis: “My dr prescribed Zyclara for use on some areas on my face she was concerned about. Zyclara gets rids if the cancerous cells. After the first few days it started working, oh boy! To be honest I looked like a drug addict, my face was red with blisters, open sores and itchy. The only side effect I experienced was a mild/moderate headache so the process was very tolerable for me. Second round and very little disruption of the skin. Before you start the treatment you may want to check your calendar for any upcoming events such as weddings, reunions, parties and such because your skin will look terrible during treatment. The initial treatment was awful but the end result and the way my skin looks is well worth the discomfort. Some insurance plans do not cover the cost of Zyclara because it’s extremely expensive. Ask your Dr for coupons or look online as most insurance companies won’t cover it.”

10 / 10
Anonymous · Taken for 1 to 6 months December 9, 2012

For Keratosis: “After I viewed some web face pics of others, I felt better about my treatment because this medicine will tear your face up. It was a lot of trouble explaining to most I came in contact with the treatment plan, and the looks on their faces were priceless. But, after a couple of months I know of 3 more people who also chose the treatment after seeing the results. One of them is a doctor and this is his statement to me, "you didn't tell me about the horrible flu symptoms, " for which I replied, "you didn't ask."”

8 / 10
dbhbunny · Taken for less than 1 month October 26, 2016

For Keratosis: “First let me start by saying that I have RA, and I used this cream for 11 days. Went through the whole red, blistering, scab and now smoother skin however, I did experience all the flu like symptoms and continue to feel horrible after almost 3 weeks off of this cream. My RA has flared, which has been controlled by medicine for 8 years, and I'm wondering if it is from the Zyclara. I really wish that I had not used this cream and I would warn anybody with RA to stay away from it.”

7 / 10
Zyclara user · Taken for less than 1 month May 8, 2014

For Keratosis: “Just to let people know there are some side effects. I got fatigue, swollen and sore lymph nodes, constant thirst, and I don't ever have anything like that happen usually I am a very healthy person so it surprised me. I used Carac about ten yrs ago and didn't have any side effects.”

SusanJD · Taken for less than 1 month March 12, 2014

For Keratosis: “26 spots came out the first week. A few were very big (larger than a pencil eraser) and they oozed like a greenish pus. but....only a tiny bit of itching during the healing weeks. Seemed to work great!”

10 / 10
Anonymous · Taken for less than 1 month January 29, 2018

For Condylomata Acuminata: “This drug is a miracle. I had genital warts, and all the distress that goes with them. They were spreading all over my vulva, down to my anus. Doctor prescribed Zyclara, told me to apply to general area every night. Reading some of the reviews on here freaked me out but I did it anyway. Nothing happened for 3 days. Was despairing, bracing myself for months, years. 4th day it started getting sore. New red spots, blisters, stinging when urinating. Applied it anyway. Next day, more soreness, though nothing so dreadful as some people report. Still no change Decided to give soreness chance to heal, didn’t apply the next 2 nights. When I went to apply it the next night I discovered that the warts had drastically shrunk. I applied it that night, took the next night off. A week and a half after starting, the warts are all gone except for a couple of tiny little bumps. I am SO thrilled and surprised at how fast it worked.”

10 / 10
58andred August 21, 2011

For Keratosis: “My bald head, forehead, and face have the actinic keratosis spots to be treated. I tried one laser peel and it did well for about 6 months. It was painful and the recovery was as well. I tried Efudex cream several times and had some success. I am on the Zyclara now for 7 days with just some itching, redness and minor swelling. I made the mistake of being in the sun for 5 hours on the sixth day and had to skip the treatment one night due to some pain. Some sores have began to appear like old zits. It wont be pretty for several weeks but it should be worth it to avoid cancer.”

7 / 10
AblesChapin · Taken for less than 1 month January 20, 2013

For Keratosis: “Have used this for one week but began to have serious side-effects including hives all over my back, severe diarrhea, terrible cold/flu, headache, joint soreness. I do have an autoimmune disorder (endometriosis and Raynaund's) and the medication has warnings for people with autoimmune disorders so that may be why I am having such an adverse reaction. Will see doctor tomorrow to learn if I should switch to Efudex maybe but will probably look into the genetic testing for DPD before I start that one.”

7 / 10
bpace May 12, 2011

For Keratosis: “Yesterday was Day 14 of my Zyclara treatment. Using it on my forehead where there was a previous basal cell, and on my chest where I currently have a basal cell. I decided to do the whole top of my chest. Wow, I have many actinic keratosis. It's really scary. No real bad side effects other than the swelling and rawness on my chest. Forehead, found 1 AK, appears to be working. I have been experiencing some lower back pain, as I did when I used the Carac Cream. Wondering if this is a side effect or not? I hope this works! Will be doing Carac again in the winter on my cheeks. ”

7 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.