Skip to main content

Zyclara and Fatigue: What Users Say

Fatigue: mentioned by 5 users (10.2%)

Based on user experiences from 49 Zyclara reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 24.5%
itching 22.4%
flu-like symptoms 20.4%
nausea 16.3%
pain 12.2%
swelling 12.2%
fatigue 10.2%
fever 8.2%
tiredness 8.2%
back pain 6.1%

Reviews for Zyclara

Commonly mentioned side effects
  • Anonymous
  • November 23, 2015

For Keratosis "I am a female in my late 60s, and on day 13 of the 1st round of 14. After tomorrow, I will be off 2 weeks and back on for 2 weeks. I am using it on my temples and forehead. Luckily, I have a lot of hair to cover the red spots that have surfaced on my temples. However, I have had NO flu-like symptoms, NO fatigue, NO stomach problems. Nothing... just a bunch of ugly red spots."

8 / 10
Was this helpful?YesNo
27 Report
  • Anonymous
  • January 19, 2012

For Keratosis "I took Zyclara for the first time a year ago at the age of 34 after my doctor froze off 3 actinic keratosis. Actinic keratosis on my nose is back, also, I still have red spots where lesions were during the initial treatment. Doctor says I need another round to finish off the damage and as a last best hope to avoid having to surgically remove the spot on my nose. I have fair skin and tons of sun damage (including 2nd-degree burns over 20% of my body). My doctor initially recommended that I take 2 months off for the treatment, this time, I will take her advice! I found the treatment too intense to work through due to pain and fatigue. Moisturizing the area with petroleum jelly and a topical anesthetic and antimicrobial (Neosporin or Polysporin) helped a lot!"

8 / 10
Was this helpful?YesNo
34 Report
  • Est...
  • February 13, 2016

For Keratosis "I am on day 11 of a 14-day cycle, and the first week I experienced flu-like symptoms, i.e., achy muscles, fatigue, and headaches. My only side effect now is a slight headache. I am using Zyclara on my face (temples, forehead, and cheek), and my face is looking pretty ugly right now. It looks like an awful outbreak of acne and is very raw. I have more than a few scabs and a lot of redness where I have been applying the cream. It is very itchy and tender, and to be honest, while I am still in the middle of all of this, I have questioned whether I would do it again. I guess it would be better to answer that in a couple of weeks. I have wanted to stop using it, but it is like swimming halfway across a lake. I think I will be happy in a couple of weeks."

7 / 10
Was this helpful?YesNo
23 Report

See also:

Frequently asked questions

  • Zyc...
  • Taken for less than 1 month
  • May 8, 2014

For Keratosis "Just to let people know, there are some side effects. I got fatigue, swollen and sore lymph nodes, constant thirst, and I don't ever have anything like that happen. Usually, I am a very healthy person, so it surprised me. I used Carac about ten years ago and didn't have any side effects."

6 / 10
Was this helpful?YesNo
20 Report
  • TMC...
  • December 9, 2015

For Keratosis "I took Zyclara for 5 days and, unfortunately, had to discontinue due to acute side effects, including fever, flu-like symptoms, nausea, lack of appetite, and fatigue. I have been off now for 4 days, and other than the fever being slightly lower, the symptoms continue. I used it on my entire face, which is swollen and covered in bright red sores, some draining. This has been a very negative experience for me, but that's the chance I took, hoping the benefits would outweigh the side effects. I believe I may have an immune issue and plan to further investigate that, as I seem to get sick a lot and am easily fatigued."

1 / 10
Was this helpful?YesNo
8 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.