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Collagenase topical

Generic name: collagenase topical [ KOL-a-JEN-ase-TOP-ik-al ]
Brand name: Santyl
Dosage form: topical ointment (250 units/g)
Drug class: Topical debriding agents

Medically reviewed by Drugs.com on Aug 30, 2021. Written by Cerner Multum.

What is collagenase topical?

Collagenase topical (for the skin) is used to treat severe burns or skin ulcers in adults. collagenase topical helps remove dead skin tissue and aid in wound healing.

Collagenase topical may also be used for purposes not listed in this medication guide.

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use collagenase topical if you are allergic to it.

Tell your doctor if you are pregnant or breastfeeding.

How should I use collagenase topical?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Wash your hands before and after applying collagenase topical.

Carefully follow your medical care provider's instructions about how to clean the skin wound and care for the wound dressing.

Collagenase topical is usually applied once daily. You may need to clean the wound and reapply the ointment if the treated area becomes soiled.

Do not share collagenase topical with another person, even if they have the same symptoms you have.

The enzymes in collagenase topical may increase your risk of infection in the bloodstream. Call your doctor right away if you have a fever, chills, rapid heartbeats, nausea, vomiting, or diarrhea, or if you feel light-headed or confused.

Store at room temperature away from moisture and heat. Keep the tube tightly closed when not in use.

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

An overdose of collagenase topical is not expected to be dangerous. If you think you have applied too much of this medication, you may wash off the enzyme with povidone iodine.

What should I avoid while using collagenase topical?

Avoid using other medications on the areas you treat with collagenase topical unless your doctor tells you to.

Collagenase topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if your skin condition gets worse, or you have new symptoms of illness or infection.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Collagenase topical dosing information

Usual Adult Dose for Keratosis:

Apply to affected areas once a day (or more frequently if the dressing becomes soiled, as from incontinence)

Use: Debriding chronic dermal ulcers and severely burned areas

What other drugs will affect collagenase topical?

Medicine used on the skin is not likely to be affected by other drugs you use, but many drugs can interact. Tell your doctor about all your current medicines, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.