Zyclara and Nausea: What Users Say

• gre...
• May 27, 2011

For Keratosis "I am on the last three days of the 2nd two-week application step. I'm using it on my forehead and cheeks, and what a mess. I'm covered in red, itchy, weeping spots and blotches. I have nausea, but that's the price you pay for baking in the sun as a kid. I'm 62. This medicine seems to work, and if you don't mind looking like your face caught fire for a few weeks to maybe save your life, then go for it."

• ecs...
• June 24, 2013

For Keratosis "I am 64 and have a lot of what my Dr. describes as pre-cancerous areas. I have just completed my 2nd two-regime, the first having been done a couple of years earlier. I did my head and the left side of my face about halfway down my cheek - only wanted to look half horrible. I took more than two weeks between the 1st and 2nd cycle both times to give the areas more time to heal. Don't know the significance of this delay. I got the eruptions to the point that I called my Dr. who said there was no problem and showed photos I took during the treatment when I next visited my Dr. - all normal. I did feel fluey, sore all over, and verging on sick to my stomach, a 200 mg IBU solved the problem - it's a real miracle for me."

• Bro...
• Taken for less than 1 month
• September 21, 2016

For Keratosis "Had been on the Zyclara, putting it on my chest only, for 10 days when I experienced high fever, chills, shortness of breath, nausea, sore throat, aching joints, headache, numbness in my fingers, metallic taste in my mouth, dry mouth, and extremely tired. Dr. told me to stop. Symptoms still continue after 5 days off. He refuses to say it's from the cream, but I am never sick and only became sick after being on the cream. Hopefully, the cream will have done its job, and after the redness and spots disappear, I will have a clear chest again. It is a chemotherapy cream, so no wonder there will be side effects. Stupid doctor for not taking responsibility for this!!!!"

• TMC...
• December 9, 2015

For Keratosis "I took Zyclara for 5 days and, unfortunately, had to discontinue due to acute side effects, including fever, flu-like symptoms, nausea, lack of appetite, and fatigue. I have been off now for 4 days, and other than the fever being slightly lower, the symptoms continue. I used it on my entire face, which is swollen and covered in bright red sores, some draining. This has been a very negative experience for me, but that's the chance I took, hoping the benefits would outweigh the side effects. I believe I may have an immune issue and plan to further investigate that, as I seem to get sick a lot and am easily fatigued."

• MLH...
• Taken for 1 to 2 years
• December 14, 2017

For Keratosis "I used Zyclara about a year ago with good results. Many lesions appeared on my head and face, and the side effects were minimal. I followed the typical application, 2 weeks on, 2 weeks off, and 2 more weeks on. Everything on my head and face completely healed in about 2 weeks after my 2nd application. Recently, I started treatment on my face and head and noticed more lesions appeared. However, into my 2nd week, the side effects were awful. Severe flu-like symptoms; lower back pain, nausea, sore throat, head and chest congestion, it sucked! I am not sure why the side effects hit me harder this time around as a year ago the side effects were very minimal. At any rate, I stopped using Zyclara, and within 4 days I was back to normal again."

• Cur...
• Taken for 1 to 6 months
• January 3, 2019

For Keratosis "Used Zyclara for basal cell carcinoma behind my ear, just smaller than an eraser head. 6 weeks straight. Did the trick with no scarring other than from the punch biopsy. No side effects other than the huge, ugly scar that formed, but I just wore my hair in a way that hid it. Previously used Aldara on my chest but did experience mild, brief episodes of nausea for a couple of days, but quite tolerable."

• Sti...
• January 5, 2018

For Keratosis "Two days after I started using Zyclara, I had diarrhea for 2 days, lack of appetite for 5 days, flu-like symptoms, and nausea for 12 days. After 8 days, my cleavage had bright red scrapes, most of which were oozing. After 14 days, I stopped using Zyclara and started again after 14 days, according to the instructions on the package insert. Again, after 2 days of using Zyclara, I had the same symptoms all over again, this time even worse."

• J17...
• Taken for less than 1 month
• February 17, 2024

"Used as prescribed. After night 1, I had felt quite a bit of burning, but after seeing it listed as one of the symptoms, I just thought the cream was doing its job. The burning continued to get worse even after I had washed it off. When it reached night 2, I began to get many other symptoms (burning, itching, cold sweats, dizziness, nausea, pounding headache, and I ran a fever of 104). I decided to go to the hospital as the fever wouldn't break, and they gave me medication to help. The doctor told me to stop using the cream immediately. Day 3, the fever was gone, but I ended up having to return to the hospital. My area was now swollen to three times its original size, I had bloody discharge, and the burn had now turned dark purple. The doctor was shocked to see my downstairs area pretty much completely destroyed. He told me this was a severe reaction to this cream and that this was essentially a bad chemical burn in the worst area possible. It's been 5 weeks, and I'm still recovering."