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User Reviews for Zohydro ER to treat Pain

Zohydro ER has an average rating of 8.4 out of 10 from a total of 49 ratings for the treatment of Pain. 78% of those users who reviewed Zohydro ER reported a positive effect, while 8% reported a negative effect.

Zohydro ER Rating Summary

8.4/10 average rating

49 ratings from 49 user reviews.

Compare all 1431 medications used in the treatment of Pain.

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Reviews for Zohydro ER

Bunnie April 28, 2021

“After many years of feeling drugged and still in pain, Zohydro ER has saved my life. I spent 11 hours on the operating table. I was in pain 24/7 even with other pain meds or I felt drugged. With Zohydro you don’t know that you have a drug in your system. JUST NO PAIN! Now I’ve come to understand that the company just recently took them off the market. WHY?”

10 / 10
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S December 22, 2020

“Have had chronic pancreatitis for years. After 5 failed surgeries and trying about 30 different medicines for pain I went to a pain clinic and got put on 10mg zohydro twice a day along with the 10mg of oxycodone every 6 hours for breakthrough pain I had been on for a year or two prior. Works amazing. Take the everyday pain down to a 1 or 2 and I can actually function and have a life now! Only side effect I had was constipation and laxatives make my abdominal much worse so got out on SYMPROIC which works well for the consolation. Only down side is trying to get the prescription at pharmacies has been kind of a pain and every month my script ends up getting filled anywhere from 1 to 3 days after my previous script has run out due to the government having new rules and regulations on ordering these types of medicines.”

10 / 10
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cjg12345 · Taken for less than 1 month January 7, 2020

“The pain clinic suggested Zohydro. This wold cost near $400 a month. You have to be aware of this and whether or not it is medically necesary for you.”

1 / 10
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Frequently asked questions

MoshPitKing April 10, 2014

“I would give this medicine 20 stars if I could. Finally a time release version of hydrocodone without any acetaminophen. I have been taking Norco 10/325 for a little over a year and it was starting to have little to no effect for my chronic back pain. I was always in constant fear about getting jumped up to oxycodone due to the Norcos not working anymore but then Zohydro comes along and changes the game! No side effects whatsoever for me and I'm getting a good 12 hrs of pain relief per dose! Another positive note is that I'm only taking 2 pills per day rather than taking 4-5 Norcos, and with the absence of acetaminophen I don't have to worry about damage to my liver anymore. THANK YOU ZO-HYDRO!”

10 / 10
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spinalwars · Taken for 1 to 6 months May 22, 2014

“I am suffering with Arachnoiditis of the thoracic spine due to 2 arachnoid cyst surgeries. Zohydro is far superior at lowering pain levels. It also does not upset my intestines or cause liver damage. At pain reduction it is A The best pain reliever ever. It also does not have the ups and downs in regards to pain levels that Norco's have. It is about time that a hydrocodone only medication has been offered and I really hope that the special interest lawmakers don't get their way and this medication remains on the market.”

10 / 10
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Patrick k · Taken for 1 to 6 months May 3, 2014

“Suffering with chronic pain from debilitating spinal injuries, I was always prescribed Acetaminophen containing hydrocodone. I was always getting bad acid reflux and digestive problems I would explain this to my original pain management Dr. And he would switch me from Vicodin to Percocet and the constant stomach issues continued. I switched to a new Pain Dr. I told him I was feeling fatigue and constant acid reflux when taking my pain medicines. He suggested trying A time released pain medicine with no acetaminophen he felt I was taking too much Acetaminophen and perhaps too many pills period (4 pills a day) He suggested to try Zohydro, I Am forever grateful I switched. Great relief of back pain and stomach problems. 10 stars.”

10 / 10
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patsysue24 · Taken for 6 months to 1 year October 8, 2014

“I have horrible arthritis pain for many years...tried everything..I've been on Vicodin (10mg) 4 a day for about 6 years..Finally a pain clinic Dr. gave me Zohydro (40mg) 2 a day. I would say I am 80 percent pain free. Overall quality of life has changed. No more ups and downs. I have to remind myself to take the second pill. Thanks ZOHYDRO!”

10 / 10
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More FAQ

Anonymous April 15, 2014

“My doctor put me on this after my blood test came back showing signs of liver problems from the Vicodin I was taking. I'm actually much more satisfied with Zohydro. It only needs to be taken once daily instead of four times. I feel more consistent pain relief without the spikes and valleys of the other. Wish it would have been available sooner I could have avoided the possible liver damage I now have to deal with.”

10 / 10
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Deenini December 30, 2014

“I have been taking Zohydro for two months now for herniated disc in back. I was taking Norco three times a day but would always wear off and with my liver condition, I was not keen on the acetaminophen that is in Norco. I can now go through my day pain free! I hope all the naysayers leave us chronic pain patients alone!”

10 / 10
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Pattipotty September 3, 2015

“I have chronic arthritis and have for 25 years. Believe me I have tried everything. Finally pain clinic doc put me on Zohydro and I have my life back. I can't tell you how much it helps. Please don't let anything happen to where FDA takes this drug away. Why do the druggies have to ruin it for the people that are in pain always. Thank you Zohydro...thank you..”

10 / 10
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finally relief · Taken for 1 to 6 months June 18, 2014

“After three years of taking oxycodone 10 ER and oxycodone 5 IR for three cervical anterior and posterior with instrument I ask my spine doctor to change me to Zohydro ER. The oxy was making me sick to my stomach and I was dizzy and tired. I have to report that after a few months on the Zohydro ER I was able to transition to not only getting off the oxy but I am almost pill free and pain free. I am so grateful for Zohydro ER. I was afraid I was getting addicted to the oxycodone and with the Zohydro ER I had no feeling of euphoria. I am so grateful. Thank you for giving me back my life.”

10 / 10
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Equus · Taken for less than 1 month September 11, 2014

“I have chronic back and neck pain from 2 car accidents, I was rear ended. Had to have a 3 level cervical fusion with titanium plate 5 years ago. I was on Exalgo 8 mg, with Dilaudid or Norco for breakthrough pain. Norco always worked better for breakthrough pain, but don't like being forced to take acetaminophen that's in Norco. Just switched to 10 mg Zohydro 2x/day. Side effects were headache, nausea and a knot in my stomach. Which lasted the first 1-2 hours. My Md gave me Zofran for nausea which worked. My pain control is great! I am also sleeping much better. I do take some Norco for breakthrough, but so much better! This is day 3, and side effects seem to be gone! Great medicine. Need to get coupon working for me. Thanks Zohydro!”

10 / 10
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TisLovingLifeNow November 5, 2015

“I have only taken Zohydro ER today. After 5 years of constant pain due to a back injury and R.A today Is the first day I have been pain free. I can actually enjoy sitting up watch TV pain free. Just 24 hrs ago my pain was so bad it ruled my life. Thanks To Zohydro ER, I see a light at the end of a very very long tunnel. The only side effect I have experienced today is I have had spells of being a bit sick to my stomach. But I do think being pain free out weighs that.”

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5-O September 23, 2015

“I was taking Norco 10mg 4x a day but it wore off so fast, I asked the doctor for an increase of 20mg. He suggested 20mg Zohydro twice a day and 20 mg norco for breakthrough pain. The medicine is pricey and I had to give it up this month. I am shopping for price comparisons and I have the company coupon that will get 250 off. I didn't realize how effective it was until I gave it up. How stupid I was! This stuff covers me from getting out of the bed until it runs out, which is about 8 hours later, so I probably need to move up to the 30s. I have an appointment in a few days and I am going to tell my doc to keep the norco's and just adjust my zohydro and I will rob banks to pay for it.! I had my life back for awhile. I miss it.”

10 / 10
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2b2bs January 21, 2015

“Beginning month 2 of Zohydro. Cannot believe the negative press! It is a long overdue blessing to chronic pain sufferers. I have multiple back issues and surgeries. The Norco 4x a day was causing about as much issue with my stomach and intestines as helping with pain. Finally asked, is there an option? Pain clinic Dr said good results with Zohydro! As we are adjusting the dosage, I take 5 mg of norco for breakthrough pain, but consider that temporary. Me, my back AND stomach are much better and much more level pain relief. Thanks again!!!”

9 / 10
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Anonymous June 12, 2016

“I was switched from Norco 5mg 4 times daily to Zyhydro ER 10mg 2times daily with Norco 5mg 2 times daily for break through pain. I tore my ACL several years ago and decided to finally have surgery. It has been many years of restless, painful nights of trying to sleep. Since starting the zohydro my knee no longer has that constant ache that doesn't go away. I can walk on my knee, and do hours of activity with out my knee being in pain. I have been on zohydro for about 3 months. My next visit we will be doing an increase, which hopefully will mean less break through pain medication. Zohydro ER does work for chronic pain. Very grateful for this medication!!”

8 / 10
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Lyndwood1 · Taken for less than 1 month January 21, 2016

“I was taking oxycontin 20 with oxycodone 15 for breakthrough qid for severe back pain/spinal stenosis. Previous surgery 30 years ago and no known surgery to help except the experimental approaches with cages to lift. I'm in the business so not interested. Anyway, knowing my pharmacology, I moved from oxycontin (4 hours half life to zohyrdro 8 hrs half life. And, its' spot on. Neither is a true BID drug but Zohydro comes close and gives you maybe 6-7 hours of good sleep and if you wake up with breakthrough, take an oxycodone, wait 45 minutesw and go back to bed. Don't take another zohydro. Fairly flexible. eally works well for me. So much better than force fitting a TID or even a QID oxycontin as a BID. Look at the pharmacodynamics please”

8 / 10
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Dano79 November 3, 2016

“I just started taking Zohydro ER 15mg 2 X's per/day. I've gotta say, so far it seems to be working pretty well. I have had two very significant car wrecks since 2004.The second wreck was in 2012 and was pretty much a career ender. I have been taking Norco, various doses (usually 7.5/325 and 10/325) "off & on," for approximately 12 years. I know, a long time, Right?! That said, I believe, speaking only for myself, that I am pretty aware of the effects, and feelings, of hydrocodone. That once warm, euphoric, feeling is long gone; but now the euphoria comes from an greatly improved quality of life, rather than the drug itself.... I probably need to increase to 40mg doses. But Zohydro is "Spot On." Terrific for long acting relief.”

10 / 10
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4Csons · Taken for 1 to 6 months July 9, 2015

“I have been taking zohydro now for about 3 months and what a difference it has made. My doctor will be increasing the dosage from the 20mg to the 40mg because I still take hydrocodone for breakthrough pain and the zohydro doesn't quite take the pain away at the current 20mg. I started at a lower dose to see if there were any reactions to the medication and to date I have had none. It doesn't last the 12 hours as it says but that has been the case with any time released meds that I have tried due to my metabolism. It is hard to find and cvs pharmacy has paperwork that their corporate office has to have completed before they will fill the prescription and that can take a month. Insurance did cover it after a formulary exemption was filed.”

9 / 10
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SammyMone · Taken for 1 to 6 months August 18, 2017

“I've been on this medication for about 4 months now and I can honestly say it has helped in giving me my life back. I have stage IV Endometriosis, a bulging disc that's pressing on nerves in my L4-L5, sciatica, and cervical pain. Before this medication I was on Nucyneta ER which was crap. I now go to a great pain doctor who promised me that I will get my life back and they have kept their promise. I take Zohydro 15mg 2x per day and Narco 750 for breakthrough, and flexeril at night. I am now able to sleep at night and make it through the days mostly. I pay $15 copay because of a prescription card and insurance. My insurance denied it at firs but my doctor advocated for me to them and they now cover it. I hope this helps someone.”

9 / 10
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victim of trauma accident · Taken for less than 1 month February 11, 2015

“I have just started this yesterday. I was in a hit &run accident that changed my life. It took over 2 years alone to finally walk as little as 25 ft with devices. I did every kind of therapy, pain medicines, patches, injections, etc. I would get some relief, but side effects prevents any return to normal routines or withstanding activities with family. My pain has truly limited my social and family life. Norco never lasts long enough, and the GI upset was bad enough to warrant the need of continuously trying to tweak the regimen. Having had a career and college degrees, I have rested to give in to the constraints of chronic pain. I have only taken 2 pills so far, but it seems to helping better, with fewer doses. I will post again in 1 WK.”

7 / 10
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Pashta · Taken for 1 to 6 months March 31, 2016

“It takes about 2 hours to start working, so it's definitely a long-acting medication. It says it lasts for 12 hours but it only lasts 7 for me, every time, without fail. I cannot just take the Zohydro ER but I need to take my rescue medication else be miserable for 2 hours before it works. It gives you constipation sometimes, even if you drink a ton of water. It seems to be weak pain relief. I wish it could work better and last longer. My doctor is switching me to a different ER pain medication now.”

7 / 10
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Nick W · Taken for 6 months to 1 year October 14, 2016

“My pain doctor put me on Zohydro after I tried Hysingla (worked great for a couple weeks, then only lasted about 8-12 hours - which can't work for a once every 24 hour medicine) and after I had been on Percocet and Hydrocodone at varying dosages and frequencies. Ive had chronic back pain for 5+ years. I'm so glad I got to try this medicine, it has changed my life. It's very expensive ($300+ per prescription before meeting my deductible), but it's totally worth it in my mind. It doesn't give you the annoying "high" that you get from short acting pain medication, no fuzzy thoughts, no exhaustion. Medicine usually lasts the prescribed 12 hours and takes about 50-80% pain level away.”

10 / 10
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Sun Dancer October 12, 2016

“Hello all. I am a chronic pain sufferer, and am allergic to most pain medications. Zohydro 40mg er works wonders for me. I take it twice per day, with one 10mg hydrocodone for breakthrough pain relief. My situation is so serious, that at times, I've wanted to die. The pain is just that bad, but now I'm getting relief~ it sort if let's levels it off, and my ability to function without the constant thought of hurting is greater. It's an absolute pain reliever.”

10 / 10
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Ina DeLoatch · Taken for less than 1 month September 21, 2015

“Suffering from a back injury from 2001. Over a couple of years nerve damage on left side started. Surgery done L4 and L3 was removed and replaced with an artificial substance. Cage over spine with 4 screws. Limited back movement.I'm in constant pain always. Last meds on was Oxycontin and percocet for break through. Put on Zohydro ER, 30 mg. It's not working.its only been about 3weeks.Asking Doc to put me back on previous meds. It was job related injury.”

1 / 10
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MzPreacher · Taken for 2 to 5 years May 17, 2017

“I have taken many different pain relievers since a gunshot wound in 1995...OxyContin, Morphine, Dilaudid, Fentanyl, and Norco. I have finally found one that works perfectly for me. Zohydro ER 40 mg, with Norco 10mg for breakthrough gives me excellent pain relief. Although the Zohydro DOES NOT last for the entire 12 hrs, the Norco steps right in there and does the job. I am able to work, eat, drive, and sleep. I wouldn't trade it for the others I have taken because their positives do not outweigh their negatives as with the Zo's. I started on the Zo ER 15 mg about 2 yrs ago, and have gradually been upgraded to 40 mgs. I'm satisfied, so no need for 50 mg as from now.”

9 / 10
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HateTextingDrivers · Taken for 1 to 2 years November 21, 2016

“I had a bad car wreck in 2011, caused chronic back pain. I have had 5 surgeries which ended up putting in a spinal cord stimulator. That helps with nerve pain, but not back pain so much. I eventually was put on Zohydro 40mg about 1 year ago. He first tried 30mg, but upped it after a month or so to be covered better. It has been a wonderful medicine to help me have a productive life. I still use (3) norco 5mg/325mg for break through pain a day. Looking at possibly moving to Zohydro 50mg next month as pain has slowly increased more lately. But all in all, it has been a great drug and has helped me live a productive life with chronic pain. The SCS also has helped tremendously. It is very expensive before meeting my deductable ($500)”

10 / 10
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Ayashi · Taken for 1 to 2 years December 10, 2015

“I suffer from chronic TMJ, I can't eat apples, steak, most foods that require you to open your mouth, or my jaw will emit a loud bone-breaking-sounding CRACK followed by waves of intense pain WAY beyond the acceptable threshold. I'm only 33. An MRI, CTScan, several X-Rays, and worthless visits to "Specialists" did nothing but empty my bank account and receive the news that I have "two displaced discs in my face, and there's nothing we can do." I was about to give up then said heck with it and sought out a pain specialist. She witnessed the horrific noise, saw the X-rays and surgeon notes, and immediately put me on ZoHydro 20mg (twice a day) and thinking my woes were addressed, then they reformulated it and it's like taking aleve.”

4 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.