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Fentanyl and Depression: What Users Say

Brand names: Duragesic, Fentanyl Transdermal System, Actiq, Fentora, Subsys Lazanda

Depression: mentioned by 7 users (1.6%)

Based on user experiences from 432 Fentanyl reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

pain 7.9%
withdrawal 5.8%
sweating 5.3%
constipation 3.0%
nausea 3.0%
drowsiness 2.5%
anxiety 1.6%
depression 1.6%
dizziness 1.6%
insomnia 1.6%

Reviews for Fentanyl

Commonly mentioned side effects
  • Fin...
  • Taken for 2 to 5 years
  • August 20, 2014

Fentanyl for Chronic Pain "I have had 5 back surgeries in four years with the last one being a double fusion at L4 to S1. This last surgery failed again, and they are now considering another one to fuse my lumbar spine all together. I have been on Fentanyl patch along with Percocet for three plus years. I take 150 mcg every 48 hours along with ten Percocet a day and still in pain. I just wish I could find something that relieves the pain to at least allow me somewhat of a better life. Right now I am basically housebound and depressed and sometimes very angry."

7 / 10
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84 Report
  • blo...
  • Taken for 10 years or more
  • January 19, 2016

Fentanyl for Pain "I have been all the way up to 150-200 mg with 30 mg breakthrough. I really had a life then but wasn't really 'there'. I couldn't find any doctor in my area to prescribe fentanyl, so all I got was 15 mg oxycodone and that's it. I have a 30-degree curve in my back, left hip damage, Crohn's disease, and now colon cancer. I'm back on them but only at 50 mg every 72 hours. It's a joke. The DEA here is cruel to people that truly need it. Tolerance included, I don't absorb oral meds but do receive very few 15's for breakthrough. I am waiting for a pain pump once my colon is removed, but can I make it? I'm angry, depressed, and want to just sleep without screaming."

6 / 10
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25 Report
  • Lac...
  • Taken for 5 to 10 years
  • April 13, 2018

Fentanyl "I have anaphylaxis, RA, multiple connective tissue diseases, then Dercum's disease made my life almost untenable. Luckily, my GP and rheumatoid specialist were aware of this disease. I was already on azathioprine and fentanyl patches. As the pain increased, my fentanyl patches have been increased to 150 mcg per hour, changed every 3 days. Azathioprine to 150 mg daily. My whole body has lipomas from my head to my feet on the right-hand side and to my knee on the left-hand side. Also internally. My lungs filled up with 2 1/2 liters of blood, and doctors started discussing lung transplants. I have practiced meditation and self-healing since I was 12, and now I'm 55. This is the only thing that stops my depression from taking complete control."

8 / 10
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12 Report

Frequently asked questions

  • tss...
  • October 9, 2014

Fentanyl for Chronic Pain "Having chronic pain in my whole spine, they gave me the Fentanyl patch. They started low dosage, then they moved me up to 75mg. At this time in my life, I also had hot flashes. I saw no warnings, nothing about that. Long story short, after the second day, I started withdrawing, and that, people, is not a pretty sight. I had no idea what was going on, so I never went back on it. There should be a warning to all doctors and pharmacies. I had to pull it off the internet to show my pharmacy."

4 / 10
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29 Report
  • Spu...
  • December 14, 2009

For Breakthrough Pain "Fentanyl is a miracle pain reliever. I suffer from pinched C-6 with nerve damage; hand, arm, face pain, migraines, loss of feeling in certain areas. I also suffer severe pain in my hip and lower legs from an unstable ileum, with loss in certain areas."

10 / 10
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7 Report

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  • Anonymous
  • July 31, 2011

For Pain "At first, the patch helped with pain. Side effects are no longer outweighing the benefits. Very forgetful, extremely irrational thinking, and agitation to the extent of verbally lashing out at loved ones. Now I am having a very hard time breathing."

1 / 10
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10 Report
  • Mar...
  • Taken for 1 to 2 years
  • October 28, 2021

For Chronic Pain "I find by the 3rd day I feel terrible, almost like I am having withdrawals. I feel depressed and have more pain."

5 / 10
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1 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.