Yuvafem and Burning: What Users Say

• AEa...
• October 23, 2019

For Atrophic Vaginitis "Amneal had two companies producing their Yuvafem product. One company located in the USA (pink packaging) and the other in Denmark (blue packaging). I did not experience issues with the product manufactured in Denmark although the packaging was inferior to Vagifem. Amneal no longer uses the company in Denmark. The product in the pink packaging manufactured in the USA is as awful as the many negative reviews reflect. Burning and itching was the worse negative symptoms for me. Why is the FDA not aggressively addressing this? I have been battling with Amneal and it isn't a pleasant experience. I plan to escalate to the Attorney General of my state. Unfortunately, too many politicians take money from the pharmaceutical companies so they do nothing to help stop this abuse. I also take issue with the majority of insurance companies refusing to cover Vagifem or charge exorbitant copays for a medication women need to maintain good health, yet many have no problem with covering Viagra."

• nur...
• Taken for 2 to 5 years
• August 30, 2020

For Atrophic Urethritis "I used Vagifem for years, and the only issue was occasional yeast infections at the beginning, but the drug was effective for vaginal atrophy. Years later, in an HMO that will only prescribe generics, so forced to use Yuvafem. Initially, it seemed okay, but in the last 3 months, I noticed symptoms of burning, itching, and UTI returned. Simultaneously, I just read that Teva, the current generic manufacturer of Yuvafem that I'm using, has been indicted by U.S. Federal prosecutors for drug price-fixing along with other drug manufacturers. While they are only under investigation for price fixing, I hope the FDA is also investigating these companies to determine whether they are interfering with the drug formulation, i.e., cutting with fillers. Caveat emptor - while Vagifem is costly, we may be throwing money down the drain with generics that have filler instead of the drug."

• Whi...
• June 22, 2019

For Atrophic Vaginitis "I have used Vagifem for years without any issues whatsoever. It worked well and caused no problems. Then my insurance switched me to Yuvafem, and it's been a nightmare. If I could give this drug a zero, I would have. Burning, redness, the feeling of having a UTI, then actually getting a UTI for the first time in 20 years, painful intercourse. The drug is completely ineffective for what it is supposed to do, and it is causing plenty of problems. When I looked at the ingredients, I see that estradiol is the same, but the carrier ingredients are different, specifically, Yuvafem uses propylene glycol. So, I could deal with the awful packaging if the drug actually worked and didn't cause so many problems, but it doesn't work and had me thinking I had some terrible infection for the last 3 weeks till my doctor and I figured out it was the Yuvafem. I will be trying out the Estring, and if I can't deal with it, I will be paying the big bucks and going back to the Vagifem."

• Ela...
• January 13, 2020

For Atrophic Vaginitis "First used Vagifem and seemed to work okay. Then, like others, was switched to Yuvafem. Started having extreme itching, so washed regularly and applied moisturizer. Then burning started too and nothing helped to get over itchy, burning, and then burnt skin. I stopped Yuvafem when spotting started. Skin began to clear up after two weeks. Then I used one tablet and extreme itching and skin was burnt again. I began to have pain in my joints, so bad that I entered an emergency room. I went off Yuvafem and 5 days later could walk again. After only one tablet, joint pain and burnt skin returned. My doctor could not find anything. He suggested that I was allergic to Yuvafem. So today, I decided to check reviews and found that Yuvafem is a dangerous drug."

• Ela...
• January 13, 2020

For Atrophic Vaginitis "First used Vagifem and seemed to work okay. Then, like others, was switched to Yuvafem. Started having extreme itching, so washed regularly and applied moisturizer. Then burning started too and nothing helped to get over itchy, burning, and then burnt skin. I stopped Yuvafem when spotting started. Skin began to clear up after two weeks. Then I used one tablet and extreme itching and skin was burnt again. I began to have pain in my joints, so bad that I entered an emergency room. I went off Yuvafem and 5 days later could walk again. After only one tablet, joint pain and burnt skin returned. My doctor could not find anything. He suggested that I was allergic to Yuvafem. So today, I decided to check reviews and found that Yuvafem is a dangerous drug."

• Dee...
• Taken for 1 to 2 years
• April 13, 2019

For Atrophic Vaginitis "1. Tablets fall out of the applicator. Half the time, I can see the tablet rattling around inside the plastic packaging before I even attempt to open it. 2. Packaging is impossible to separate. I have to use scissors. I'm only 52 and don't have arthritis-I can only imagine the struggle older women must have to open the packaging. 3. It doesn't work as well as Vagifem! I've been using it for over a year now and find that my symptoms of dryness, burning, etc., fluctuate from package to package. I never had this problem on Vagifem."

• Bla...
• Taken for 6 months to 1 year
• August 3, 2017

For Atrophic Vaginitis "No problems with Vagifem. After using Yuvafem for a couple of weeks, I started getting a discharge and feeling like I had an infection with burning and itching. It feels as if I am allergic to something in the drug. Going back to Vagifem."

• Glo...
• Taken for 2 to 5 years
• April 12, 2019

For Atrophic Vaginitis "This drug contains polyethylene glycol, which can be an irritant! Read the label! No wonder I had constant burning whenever I used this drug. The FDA needs to be alerted so other women will not be harmed by it. I had three biopsies of my skin in the vaginal area, which all came back as precancerous. It required constant medication just to keep it from getting worse, but it never completely healed this area. When I finally discovered the glycol and quit using it, my skin has returned to almost normal!"

• Jul...
• Taken for 1 to 6 months
• September 5, 2022

For Atrophic Vaginitis "Not Pleased · Taken for less than 1 month · March 22, 2021 “... I experienced soreness, burning, itching, and increased need to urinate, plus greenish discharge. I’m discontinuing immediately.” (Posted by NotPleased on March 22, 2021.) Ditto. I thought something was wrong with me until I started reading reviews for this product online."

• Sam...
• Taken for 1 to 2 years
• February 16, 2019

For Atrophic Vaginitis "Can only use brand name Vagifem. Generic does not work at all. Packaging is horrible, and symptoms of burning, itching, dryness, and feeling of a UTI, and constantly having to urinate are what happens when using generic. Had to go back to using Vagifem. Unfortunately, the copay is really high until I meet my deductible. Insurance needs to offer this medication at a more affordable cost."

• Cat...
• June 21, 2017

For Atrophic Vaginitis "My doctor put me on Vagifem in December, and within weeks, I felt great. In April, I got my refill, and it was switched to Yuvafem. By mid-May, all my symptoms were coming back, and I was miserable, constantly felt like I had a UTI, and the dryness and burning were awful. My doctor switched me back to brand name, and I am slowly improving again. Yuvafem did not work for me at all. I agree with the others that the packaging was terrible as well, I had to use scissors to open each one, and then the tablets would fall out because they were not in the applicators."

• Bml...
• Taken for 1 to 6 months
• October 2, 2018

For Atrophic Vaginitis "After using this medication for only 2 weeks, I called my doctor because of extremely severe vaginal burning. Even after modifying the treatment days, symptoms continued. I discontinued this TERRIBLE medicine, and all the discomfort, burning pain disappeared. So, for this reason, I will not use this drug."

• Jan...
• Taken for 10 years or more
• December 5, 2018

For Atrophic Vaginitis "I was on Vagifem for 10 years without any problems, except Medicare kept raising the copay. But I was very willing to pay my share of well over $200 for three months' supply. Then Medicare stopped covering it and changed to Yuvafem. Last Friday, I used my first pill insert and felt some burning in the vagina and urethra. It finally subsided after 12 hours. The following Tuesday, I inserted my next dosage, and 3 hours later, woke up with intense burning. I had to get an ice pack to help ease the terrible burning. I will be calling the manufacturer, my GYN, and my insurance. I will ask my GYN to prescribe me the Vagifem and pay for it out of pocket. I can NOT endure another night in this intense burning!"

• Mar...
• Taken for less than 1 month
• May 17, 2022

For Atrophic Vaginitis "I tried Yuvafem right after using Vagifem for 10 years. Much to my disappointment, I had to stop using Yuvafem because all it did was continuously burn inside my vagina. I gave it 3 weeks, and I just couldn't tolerate it any longer. So, I had to bite the bullet (cost) and go back to Vagifem. I'm a senior citizen living off of SSI, and I'm very worried how much longer I will be able to pay for this important medication. The drug companies, pharmacies, and insurance companies are robbing us!"

• Con...
• December 9, 2020

For Atrophic Vaginitis "After 2 years of using BI pellets for HRT, had to choose an alternative and chose Yuvafem. Got Yuvafem but assumed it would work the same. Yuvafem application tool very uncomfortable to insert. About 2 weeks of using this product, had some discharge and itching. Thought - yeast infection and purchased a 3-day OTC. But didn't use it and the next day the symptoms were gone. After 2.5 months of using Yuvafem, recently started noticing what looked like a brownish discharge/spotting. Spoke to an ob-gyn's nurse, decided to wait till Monday and see if it's better. That night I had burning inside my abdomen. All weekend, felt like I had a UTI with abdominal and back pain. Monday, my GP doc did a urine test which was negative. After an additional 24 hours, the culture was still negative for UTI. At that point, started reading reviews about Yuvafem and found many similar stories to what I am experiencing. I will not use this product again and I hope the burning and internal pain go away soon!"

• Not...
• Taken for less than 1 month
• March 22, 2021

For Atrophic Vaginitis "After the 10 days of the first 14-day regimen of Yuvafem, I experienced soreness, burning, itching, and increased need to urinate, plus greenish discharge. I’m discontinuing immediately. I had the same symptoms when the pharmacy used to substitute generic birth control pills (Chryselle) for name brand pills, so there are obviously problems with the estrogen and/or fillers for both generic products."

• dom...
• Taken for 1 to 6 months
• June 21, 2021

For Atrophic Vaginitis "In the beginning, I had repeated UTIs. One doctor suggested it might be menopause symptoms. I went to the gynecologist, and she gave me Imvexxy first. It did not help. I still had the terrible burning, so she switched me to the Yuvafem. I've been taking it for a couple of months now. I don't really like the applicator, it hurts. If you use lubricant, it will go in easier. Sometimes I have no symptoms at all. But for whatever reason, they will come back, not as bad, but it's there. I have to use Replens moisturizer on those days. I never tried the other, my insurance will only pay for the Yuvafem even though I was written a script for the name brand and not Yuvafem. I have not had any joint pain or discharge. If the insert is not inserted all the way up to the plunger that you push in, the pill will come out. I only had the pill fall out once. I knew I had not put it all the way in. So far, that is the only one I have found."

• Tot...
• Taken for less than 1 month
• November 13, 2020

For Atrophic Vaginitis "After one dose of Yuvafem, I will not use this awful stuff! I had discharge and burning and feeling like I have to pee. I can't believe how horrible this stuff is. I will be reporting it to the FDA."

• Pja...
• Taken for less than 1 month
• February 27, 2021

For Atrophic Vaginitis "I have been using Yuvafem for 6 weeks. I experienced extreme burning and nausea in the last 2 weeks. Also, presented with a yeast infection. Terrible product! Will never use again. So disappointing."