Doxylamine / pyridoxine and Sleepy: What Users Say

• Aug...
• Taken for less than 1 month
• January 25, 2020

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "When I was originally prescribed Diclegis, I was told to take 2 at night and my Zofran in the day as needed. After 3 more visits to the ER, my doctor changed the dose from 2 to 4 a day. One in the morning, one in the afternoon, and the 2 at night. This was the ONLY thing that worked to end my 24/7 nausea. It does make me super sleepy at times, but I'll take that over constantly feeling like I'm dying ANY DAY. Feels good to be able to enjoy a glass of water and a snack without fear of vomiting and having stomach acid come up."

• Jes...
• Taken for 1 to 6 months
• October 27, 2019

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "This medicine has honestly worked wonders for me. My morning sickness was so bad that it was through the whole day. I did read reviews prior to buying it, and a lot of people stated it makes you very sleepy. This is true. So, I decided to only take one pill at night before bed, and since it's an extended-release tablet, it has helped with my sickness all the way up till the evening of the next day. It does knock me out for the night, and I don't recommend taking it during the day if you work or have things to do. But it really does help with the sickness! I didn't have an appetite at all and barely could even drink anything...NOW I'm able to tolerate food and drink more. I don't have as much of an appetite like before being pregnant but am still able to eat a fair amount. If you're thinking and debating about the medicine, just do it, it seriously does help if you take it continuously!"

• SSa...
• Taken for 1 to 6 months
• May 3, 2020

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "When I was around 6 weeks pregnant, I was vomiting NONSTOP. It got to the point where I could not even hold down water. The doctor prescribed me Diclegis, and it has been a MIRACLE drug. I take two tablets at night before I go to bed (caution that it does make you very sleepy), which I find an added perk because it helps me get a full night's rest. There are some mornings where I wake up still feeling slightly nauseous, but I am not vomiting, so the occasional slight nausea I can deal with. If you’re looking for something to make the 1st trimester nausea/vomiting disappear (or almost disappear), look no further because this is the drug for you."

• Pau...
• March 23, 2017

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "This was the only medication that helped me deal with morning sickness, that actually it was never just in the morning. I was sick all day and all night. It makes you sleepy, but it's not like you can't get out of bed. They tell you to take 2 before bed, another one in the morning, and one more at noon, but I'm just taking one before bedtime and one in the morning so I don't feel super sleepy, and it works perfectly for me! No more sickness, and I can eat anything I want :) Plus, it's super safe for the baby!"

• Dom...
• Taken for less than 1 month
• September 25, 2019

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "Saved my life is an understatement. I suffered so badly with morning sickness with my first daughter, and Zofran didn’t work at all. I was sick the whole 8 months. With this pregnancy, I experienced HG again, but this medicine literally gives me my life back. It does make me a little sleepy, but I’ll take sleepy over nonstop heartburn and vomiting any day."

• Jen...
• Taken for 1 to 6 months
• July 31, 2020

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "Bonjesta has been an absolute miracle lifesaver for me. This is my 5th pregnancy with horrible morning sickness 24/7. Diclegis didn't work, Unisom barely worked, and I used to take Zofran daily to function. I had to pay out of pocket for this, and it has saved me. I am still nauseous, but I can eat, drive, and function, and no more throwing up! I was sleepy for the first few days, and it takes about a week to really work, but now it's AMAZING. Highly recommend, and it's super safe!"

• Exp...
• Taken for 1 to 6 months
• July 13, 2016

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "I have all-day sickness. I started taking it around 9 weeks, after 24 hours of straight vomiting, and when I woke the next day, I was able to keep something down. Initially, I was sleepy, but I started taking 1 pill every 6-8 hours, and I usually have no sleepiness issues, and I'm able to eat throughout the day. I'm 16 weeks and still on it because without it, I still have times/days when I feel sick. When I forget to take a dose is when it doesn't work - I think each person will need to figure out the best times to take it."

• pre...
• Taken for 1 to 6 months
• December 15, 2020

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "I was started on Bonjesta early in my pregnancy to prevent all-day nausea and vomiting. This medication was extremely effective for me. I didn't get dizzy or sleepy. I wasn't gaining any weight because of extreme vomiting until I started this med."

• Ana...
• Taken for 1 to 6 months
• June 1, 2019

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "I wanted to feel better with Bonjesta. My doctor prescribed it at 7 weeks, and I have taken it twice a day, but I still throw up twice a day, and I'm almost at 14 weeks. This also makes you extremely tired and sleepy."

• Che...
• March 31, 2016

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "This medication has been a lifesaver. I had terrible all-day nausea, was losing weight from throwing up. As soon as I started taking it, my nausea decreased about 90%, if not more. It does make you a bit sleepy, but I'll take that any day over nausea. Downside is the cost. They tried to charge me $750 for 100 pills. Luckily, I found a coupon online that got it down to $250. Pricey, but well worth it. Went from feeling like a sick zombie to feeling like a normal functioning human again. I was very hesitant to take any medication and do want to try to cycle off soon. I am almost 16 weeks now."

• Anonymous
• Taken for 1 to 6 months
• February 18, 2021

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "This medication did not work for me at all. I never got relief from nausea and actually threw up twice while on it. I stopped taking it, and the next morning I actually woke up feeling okay. Started a new medication (Zofran), so we'll see if it works. The Bonjesta made me sleepy, especially when taking one at night and one in the AM, but it never helped the nausea!"

• idk...
• Taken for 1 to 6 months
• September 4, 2019

For Nausea/Vomiting of Pregnancy "This medication makes my life livable. I’ve been taking it from 12 to 28 weeks and will continue until I deliver. I’ve gone without it twice and deeply regretted it. I was finally able to keep food down and start gaining weight with my pregnancy, thanks to this medication. I take one before bed, and I do think it helps me sleep. On days I’m really sick, or if I miss a dose, I’ll take it in the morning, and it doesn’t make me groggy or sleepy. I truly couldn’t survive without this stuff!"

• 025...
• Taken for 1 to 6 months
• January 26, 2016

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "At first, the Diclegis seemed to work somewhat. I was no longer vomiting, though I was still gagging at times, but I was glad to be able to keep my food down. However, now I'm in my 2nd trimester at nearly 14 weeks and taking 3 a day, and the nausea is on and off all day, the gagging is intense, and I have even thrown up a few times. I'm not sure what is going on, the doctor even took me off my prenatals to help the nausea, and nothing seems to work. I was planning on decreasing my dose soon and getting off the medication, as I'm still skeptical and concerned about the long-term effects it could have on my baby. This medication also makes me very sleepy all day. It makes it really hard to wake up at 5 a.m. for work."

• Tif...
• January 3, 2016

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "Dealing with HG with all my pregnancies. This is my 3rd, and Diclegis is an absolutely life saver. I'm afraid skipping a day to see if it's actually the pill or a good pregnancy. I went from throwing up 40x a day with my last pregnancy to one or none! I hope it'll help with heartburn also, then it will be a 10 lol. Now, it will make you sleepy and hard to get up the next morning, another reason I'm giving it an 8, but I'm now 12 weeks, and it's actually not getting me too sleepy anymore as my body is getting immune to it."

• Car...
• Taken for 1 to 6 months
• January 23, 2023

Doxylamine / pyridoxine for Nausea/Vomiting of Pregnancy "I am 35, and this is my first pregnancy. My 24/7 nausea with occasional vomiting hit me like a steamroller at 7 weeks. I was taking the over-the-counter Unisom PM at night and B6 supplements with food during the day, I noticed very little difference. At 9 weeks, I started Bonjesta, prescribed by my midwife. She did warn it could be costly, I was/am lucky, and my insurance covered all of the cost, except for a $40 copay, so it was an easy decision for me to try it. I took my first dose at night and then in the morning, and I remember going to work and feeling for the first time like I could function and get through this. It does make you very sleepy! I took two pills a day weeks 9-18 and now am taking one pill at night and adding the over-the-counter B6 supplements during the day with food. I still am careful and vigilant, but I feel so much better on it."