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Doxylamine / pyridoxine and Fatigue: What Users Say

Brand names: Diclegis, Bonjesta

Fatigue: mentioned by 5 users (3.0%)

Based on user experiences from 165 Doxylamine / pyridoxine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 46.7%
vomiting 30.9%
drowsiness 21.8%
tiredness 12.7%
sleepy 9.1%
dizziness 4.2%
insomnia 3.6%
fatigue 3.0%
upset stomach 3.0%
constipation 2.4%

Reviews for Doxylamine / pyridoxine

  • Ste...
  • Taken for less than 1 month
  • January 6, 2017

For Nausea/Vomiting of Pregnancy "The first time I took it, I took one pill upon waking up. I literally stayed in bed the entire day. I could hardly open my eyes, let alone lift my head off the pillow. Thank goodness it was a weekend, and I didn't have to work! I chalked it up to a bad morning sickness day and took two at bedtime that night. The next morning, it wasn't quite as bad, but it was still a struggle to get through the day. I wasn't nauseous, but I was so fatigued and sleepy, and just felt 'bad.' I realized it might be the Diclegis, so I didn't take any more after that. So now I'm back to all-day nausea (no vomiting), but at least I can function! I only recommend Diclegis if you've got major vomiting/HG. Otherwise, the side effects just aren't worth it."

2 / 10
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  • Aly...
  • Taken for less than 1 month
  • December 25, 2016

For Nausea/Vomiting of Pregnancy "Third pregnancy, and Zofran wasn't cutting it for me. Midwife prescribed Diclegis - felt insanely better the next morning nausea-wise, but was super fatigued. If you miss a dose, it will rock your world. For the first few days, it knocked me out all night and made me feel sleepy all morning. Now I seem to be experiencing the insomnia/nightmares side effects, and it's not fun. I'm hoping in a couple of weeks I can wean off of it because I generally feel better a couple of weeks into the second trimester. Definitely think the nausea aid is worth the side effects, though - guess it all depends on how bad your nausea/vomiting is - and if this works for you!"

7 / 10
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5 Report
  • Mau...
  • May 12, 2017

For Nausea/Vomiting of Pregnancy "With my 1st pregnancy, I suffered from severe morning sickness to the point that I lost a significant amount of weight. With my second pregnancy, I started getting very sick again and mentioned it to a nurse at my OB-GYN office, and she prescribed me Diclegis. Prior to that, I had tried many other homeopathic solutions such as the Sea Bands and ginger. None of these worked for me. The Diclegis worked from the morning after I first took it until now. At 12 weeks pregnant, I thought I might be out of the woods, so I stopped taking the Diclegis last night. I have been nauseous all day and vomiting! It is obvious that these meds work. I will be taking them again for the next 2 weeks. Only complaint is I'm more fatigued than usual when taking it."

9 / 10
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4 Report
  • Ms ...
  • Taken for less than 1 month
  • March 17, 2018

For Nausea/Vomiting of Pregnancy "I was afraid to take any medication, but my nausea was so bad that I was left with no choice. It didn’t seem to work the first week because I didn’t take it as prescribed, because it made me so sleepy, and I still had to work and take care of my other two kids. I buckled down and took it morning, noon, and night as prescribed. The nausea finally let up, and I felt much better, but I never really felt like myself. I was low on energy and just felt foggy. My stomach would rumble every time I ate or drank anything. I had anxiety about leaving the house because I always felt that I had to use the bathroom, but I was constipated. I listened to my body and stopped taking the medication for a few days, and I felt like myself again, energetic and clear, but that didn’t last long. Once that medicine moved out of my body, I got sick as a dog. I’m taking the pills again, but here come the side effects: insomnia, nightmares, lightheadedness, and fatigue. I hope the constipation doesn’t come back."

7 / 10
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6 Report
  • Jes...
  • January 13, 2017

For Nausea/Vomiting of Pregnancy "This was a miracle medicine for me. I had extremely high hormone levels during my pregnancy, and the vomiting and nausea were unbearable. I lost 10 lbs in three weeks and could not even walk. My doctor prescribed Diclegis, and within an hour or two of taking my first dose, I was able to get out of bed. Within a day, I was able to eat and function as a mother for my other two children. The only side effect I've had is fatigue. I absolutely recommend this drug to everyone."

10 / 10
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5 Report

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