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User Reviews for Desipramine

Also known as: Norpramin

The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Condition Avg. Rating Reviews Compare
ADHD 6.0
1 reviews 40 medications
Depression 9.0
15 reviews 81 medications
Irritable Bowel Syndrome 8.1
10 reviews 137 medications
Vulvodynia 8.5
2 reviews 9 medications
Summary of Desipramine reviews 8.5 28 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Desipramine

TonyB · Taken for 1 to 6 months February 29, 2020

For Irritable Bowel Syndrome: “My doctor prescribed this to me about 3 weeks ago. I had severe abdominal pain in my upper right quadrant that he is attributing to IBS. I have had no decrease in my pain levels while eating or my ambient pain levels. The diarrhea that I've had for the past 9 months stopped abruptly ending in constipation. I've had panic attacks, mood swings, I'm already prone to suicidal ideation so I don't know how much it's actually affected that but it's present. I don't really have restful sleep anymore. Nobody can help me.”

2 / 10
Red · Taken for 1 to 6 months December 27, 2019

“This desipramine lessened my nerve pain (burning) to a tolerable level. My pain is from Occipital neuralgia”

Hithere · Taken for less than 1 month June 12, 2018

For Depression: “The first anti depressant along with Lamictal that I've tried in 25 years for my bipolar 1 that actually is an antidepressant. I think that sums up my experience.”

9 / 10
Linkin60 · Taken for less than 1 month June 9, 2018

For Irritable Bowel Syndrome: “So I just started Desipramine for IBS 25mg 2 weeks ago. While I am sure that it is helping my IBS, I have had some very serious issues with taking this medication because I was also on Cymbalta (30mg) and Trazodone (75mg). My Gastro doc knew I was taking these other antidepressants when he prescribed the Desipramine for the IBS. On day 6 of taking all three of these drugs I started experiencing SSRI Syndrome. They immediately took me off the Cymbalta and the Trazodone and now I am suffering major withdrawal symptoms. Has anyone else had this happen to them? How long before the Cymbalta and Trazodone get out of my system for good?”

8 / 10
Trish · Taken for less than 1 month May 8, 2018

For Irritable Bowel Syndrome: “I have been on this med for three weeks and have really found it helpful for IBS-D. I am also following FODMAP diet-mostly. The diet is really helpful to know what foods are triggers. Now I am having trouble without diarrhea I have a bowel motion up to three times a day. Dry mouth is so far the only side effect. Also got an extreme sunburn when in normal circumstances I would not have.”

8 / 10
rberger2 · Taken for 1 to 6 months March 6, 2018

For Depression: “Best antidepressant in 30 years. However effective is starting to wear off after 3 months. Experience side effect prickly Burning Sensations”

8 / 10
another Jim · Taken for 10 years or more December 8, 2017

For Depression: “I have had trouble sleeping all my life. Too much rem sleep and waking exhausted In my 30s I was placed on a regimine of desip and trazadone. They worked well together but I quickly developed a tolerance and had to stop taking them. In the intervening years I tried seemingly every other anti depressant to try to get the same effect but nothing worked. Finally I demanded these 2 drugs from a young Dr who had never heard of them. After consulting with an older physician he allowed me to have them and I have created a 3 week regime that keeps me from building tolerance. I take a small dose 6 mg desipramine every other day (it works for 2 days but not 3). After two weeks I do a week of 50mg trazadone allowing my body to "forget" the desip. And in 2 weeks it "forgets" the trazadone.”

10 / 10
Lucky Larry · Taken for 10 years or more May 18, 2017

For Depression: “I’ve been taking desipramine (the generic from Actavis) for depression since 2003, returning to it after trying many other meds. It’s the only one that helped, although high doses caused shortness of breath, low-back pain, nightmares, stress, and anxiety. The key has been finding the correct dose. An important discovery was that chocolate produces a synergistic effect. Taking it in the evening right after a large serving of dark chocolate and 10 ounces of milk allows me to keep the dose and prescription costs low. It’s not nearly as effective without chocolate during the day. But a problem is that it’s addictive. Increasing the dose made me more depressed but going down improved my mood, so finding the optimal one has been difficult.”

9 / 10
GERDIE May 3, 2017

For Depression: “I was really surprised to see a post from Joanzie (taken for 10 years or more) November 15, 2016 today when she indicated her pharmacy could no longer get it. I have taken Desipramine (Generic is Norpramin) for nearly 10 years now and have no problems getting it Amneal makes 10 mg pills, but I am now switching to 50 mg. LGM Pharma makes it, but I'm sure there are others. I have used it since 911, as it really did a number on me. If I forget to take it, I know it, as I end up in lala land, as my head just feels like it is detached from my body. As long as I take the drug when prescribed, I'm steady Eddie!”

10 / 10
Mrs Lisa April 9, 2017

For Irritable Bowel Syndrome: “I had Irritable bowels ever since I was a young teenager and I just couldn't figure out what was exactly wrong I thought it was menstral related . I suffered for years until I was about 40 years old dealing with cramps in my bowels ( lower abdominal area) I realized after I had a hysterectomy it wasn't my endometriosis I still had this cramps feeling every day! :( I started taking desipramine , a fiber pill (citrucel) and a probiotic (align) and I haven't had hardly any issues ! I am like 95 %better . Sometimes if I feel a little crampy I drink a morracan mint tea and it settles things down really quick . I got lazy one week about taking this regimen and I got so irritated . So I know it works and I'm sticking with it .”

10 / 10
edenbensal · Taken for 2 to 5 years February 8, 2017

For Irritable Bowel Syndrome: “I'm suffering from IBS since I was 13 years old. Today I'm 24. This medicine made my IBS symptoms almost completely disappear.”

9 / 10
Joanzie · Taken for 10 years or more November 15, 2016

Norpramin (desipramine) for Depression: “I took this drug for over 20 years. It worked extremely well for me. Dry mouth was my only side effect. I was told by my pharmacy they could no longer get it. I took the generic for a while but it never worked as well. I was surprised to read others have taken it recently. How sad something that worked so well for many is hard to get. I would switch back in a heartbeat.”

10 / 10
Momof2inMD · Taken for 1 to 2 years November 2, 2016

For Vulvodynia: “My daughter suffered with vulvodynia for 2 years as a child at 5 years old. After seeing numerous doctors, she saw a Dr at Univ of Michigan who prescribed Desipramine. It worked immediately and it was 100% effective. After 2 years of treatment, my daughter was fine and the vulvodynia never returned.”

10 / 10
mikrw33 · Taken for less than 1 month October 18, 2016

For Depression: “One of the best-responding antidepressants I've ever taken. Unfortunately, I had to stop taking it because my resting heart rate went up to ≥ 100 bpm while on this medication (could've been interacting adversely with my Dexedrine). But wow, what a response I had! It started responding just a few weeks after increasing it to 75 mg, and it seemed to really bring me out of my cocoon at 100 mg-125 mg. That was the highest I ever got to try before realizing what was going on with my heart, and subsequently having to back down on the dosage. My positive response diminished, and I had gained a bunch of weight anyway, so we decided to switch meds.”

10 / 10
Scuba Steve 6173452 October 5, 2016

For Irritable Bowel Syndrome: “Have tried all families of the tricyclics and xifaxin for my IBS-D. Desipramine is the only medication that has helped and continues to provide relief. It takes about a month to start working and gets better and better over time. The only side effect is trouble sleeping and it does have an odd effect on my testicles which makes them feel tight. However, for Ibs-D this is the only med that works. I take Imodium as well when I am having a bad day or before a big event and this calms my nerves because Imodium always helps. After about 3 months on desipramine, Imodium is no longer needed.”

8 / 10
Best I've Tried · Taken for 2 to 5 years September 24, 2016

For Irritable Bowel Syndrome: “Looking for an alternative but there was a time when I would have killed to find this. I noticed effects @lowest dose & no more diarrhea now: 10 mg morning, 50 @night. Helps anxiety& better than SSRI (took B4) which helped psychosomatic. W/this, too much = constipation(!!) Alcohol, pizza, extreme grease=still diarrhea. Occsnlly I will stop 4 wknd or days, bc of sexual side effects: NOT as bad as SSRI. But less interest in sex, lack of sensation leading up to orgasm. Can orgasm, but not the same level. (I'm female). Compared to life without it though? It's a lifesaver and I am normal again. Mostly. [Also take Wellbutrin 450 & Clonazepam 0.5x2. W helps w/sex effects (+lose weight & more energy, social).] + so cheap.”

8 / 10
Anonymous · Taken for less than 1 month July 14, 2016

For ADHD: “This drug seemed to help my pain although the side effects I experienced outweighed the relief. I started with one 10 MG tablet per day for one week. On the second week I increased to 20 MG per day. At the end of the second week I noticed a difference in pain. I was having stomach aches, dizziness, constipation, loss of appetite, an in body shakiness and my voice was weak and kind hoarse. Although my pain was considerably less by the third week I felt all I could do was lay and hope the terrible feelings I was having would go away. I was unable to even make it to work at all on the third week. My lips were dry, swollen and I woke up to them cracked and bleeding.”

6 / 10
1122334455 · Taken for 10 years or more April 3, 2016

Norpramin (desipramine) for Depression: “I did so well on this medication! But I can no longer afford it. The generic version I was paying $280 a month. I have since changed to Effexor, and now on Zoloft and neither one works as well. I had been on this since 1986, but had to change last November because of the cost. I miss it so much”

10 / 10
phenylalanine · Taken for 1 to 6 months March 28, 2016

For Depression: “Did not notice any effect whatsoever.”

1 / 10
Bobbert1112 September 10, 2015

For Irritable Bowel Syndrome: “I have had IBS all of my life and have tried many things and none of them did anything for my IBS. I started taking it as my DR said it is a side benefit of this drug which was not intended for IBS. It works very well. I use to go to the bathroom 3-5 times a day with frequent diarrhea now I go just once or even every other day and no diarrhea or bloating. I only use 25 mg as more gives me constipation.”

10 / 10
Chloe1212 April 27, 2015

For Irritable Bowel Syndrome: “I have IBS and am trying to following the FODMAP diet which is very difficult and limiting. I began to take just 5 mg. of Desipramine a week ago, and haven't had any IBS symptoms. Are other people using the FODMAP diet???? If Desipramine quiets the symptoms of IBS, I would love to get off the FODMAP diet because of the strict limitations. Thanks for any feedback.”

9 / 10
JenniferRose · Taken for 6 months to 1 year January 21, 2014

Norpramin (desipramine) for Depression: “I have spent years going through one anti-depressant after another. I even did ECT treatments and nothing worked. My psychiatrist then put me on desipramine and I have never looked back. I have energy, I can concentrate, get out of bed, and function for the first time in years. I've been taking it for 6 months now and have not had to increase the dosage, either. It was truly a godsend.”

10 / 10
EJstultz · Taken for 2 to 5 years February 8, 2013

Norpramin (desipramine) for Depression: “It was the God send of meds for me!”

9 / 10
DoktorRowan · Taken for 2 to 5 years January 29, 2013

Norpramin (desipramine) for Depression: “Desipramine has worked wonders for me. After many years on and off of various medications that would - at best, if they worked at all - help briefly and degenerate into vicious side effects, this one worked like a charm. The only down-side is that it is so innocuous that it's easy to get used to the improvement; since the improvements it can be tempting to consider oneself "better" and discontinue prematurely. Fortunately there are no discontinuation effects, and the only side effect I have experienced is slight photosensitivity.”

10 / 10
EAG November 29, 2011

For Depression: “To treat depression, I have been on Wellbutrin, Zoloft, Celexa, Effexor and Cymbalta. None worked as well as desipramine. I have been taking 30mg of desipramine combined with 50mg Zoloft and I feel much better. It took a few weeks of ups and downs before it really kicked in.”

10 / 10