Conjugated estrogens / medroxyprogesterone for Postmenopausal Symptoms User Reviews (Page 2)

• Anonymous
• Taken for 10 years or more
• June 7, 2022

Conjugated estrogens / medroxyprogesterone "I have been on Prempro for 25 years. Every time I try to wean myself off, I feel tired, moody, bones hurt, and not happy. My doctor thinks I should try weaning myself off again, my husband says, oh no... the world's not ready for that. I call it my happy pill. I’m 65, just tried again and decided if I am going to die, rather die happy than how I feel without it."

• Kat...
• Taken for 1 to 6 months
• May 14, 2022

Conjugated estrogens / medroxyprogesterone "I was lucky to not experience menopause until 55, but moderate hot flashes became annoying, so the doctor prescribed low-dose Prempro. At first, everything seemed fine, but after a couple of months, acne and weight gain ruined it for me. I was seriously waking up every couple of days with new pimples, and I've had good skin my whole life. Weight gain and bloating also started, and I've been thin my entire life. So no way I'm living with blotchy, bad skin and a pot belly to solve a few hot flashes."

• Mcm...
• Taken for less than 1 month
• November 19, 2019

Conjugated estrogens / medroxyprogesterone "So I was taking Remifemin, which wasn’t working for me, so I asked my doctor about HRT. I was having severe hot flashes at night, where I was soaking wet, and hot flashes maybe 3 to 4 an hour at 48 years old, and I’ve stopped my period pretty much eight months ago. I am on my fourth day and really haven’t seen a difference in hot flashes and night sweats yet, still bloated and very sensitive, like crying at really stupid stuff... lol. I’m looking forward to seeing how this medication works, but it is awfully expensive, but thank God I can somewhat afford it."

• SoC...
• Taken for 10 years or more
• October 15, 2022

Conjugated estrogens / medroxyprogesterone "I've taken Prempro for years since I was 45. I've always bought it from an online Canada pharmacy, Best Rx (with prescription). Recently ran out, didn’t think much of it. Had a doctor's appointment. Within 2 weeks, I've had the worst hot flashes and all other menopause symptoms. Honestly, couldn’t believe how uncomfortable. I ordered from Canada, but because of timing, had to pay (Walmart cheapest) $233 copay for a 28-day supply. 5 days with Rx, it’s getting better, still have unbearable heat flushes, but less of them. Ask the doctor for a written Rx, scan it to Best Rx, then go buy a 1-month supply. Stage your Canada purchases because it can take 4-5 weeks. It cost $98 for a 90-day supply, 10/12/22 just takes a while to get it and they send Premarin (Pfizer estrogen med) + progesterone, which is what I’ve taken as ‘Prempro’ for a decade. My doctor gives me 0.0625 /2.5 and said to take it every other day. My mother took Premarin until she was 85, could still ride a bike, great bones & skin!"

• Sam...
• Taken for 1 to 6 months
• February 8, 2021

Conjugated estrogens / medroxyprogesterone "After having a complete hysterectomy, I started hot flashes that same day of the surgery. At my 2-week post-op, I was a mess, wasn’t sleeping, hot flashes, crazy emotionally. My doctor started me on Prempro. Sticker shock on the cost, $206 for a 1-month supply! After a month, I felt great, sleeping and less emotional. A few months in, I started experiencing migraines and awful cramps in my legs. I didn’t want to go off Prempro, but the migraines were happening so often that I couldn’t get my work done, so I had to discontinue it after 6 months. I’ve since switched to a doctor that uses a compounding pharmacy and am trying to find the right combination of hormones."

• Chu...
• December 3, 2011

Conjugated estrogens / medroxyprogesterone "Took this medicine for 18 days. Hot flashes, nausea, and migraines disappeared after about a week. Then, on the 10th day, I felt nausea and a migraine come on, since then, no more symptoms. Not sure if it's okay to not take it anymore now that I feel better."

• Clo...
• Taken for less than 1 month
• March 12, 2019

Conjugated estrogens / medroxyprogesterone "I started the lowest dose of Prempro just 5 days ago. The GYN said it would stop/diminish the hot flashes, which in the last 5 months have been so debilitating I'm barely functioning. (Roughly every 45-90 minutes, for 8 minutes each, 24/7) I have been astonishingly moody, weepy, and fearful for the last 3 days, more than I can ever remember being since I was a teenager and new to my periods. However, I've lost most of my appetite, and although I feel 10x more stressed out inside, despite meditation and yoga, I will continue for as long as I can endure it because it's such a relief to be having fewer hot flashes. (Not gone, but maybe half as many!) However, at several hundred dollars per month for the drug, this won't last long. I figure I'll give myself a two-month break from hot flashes and then go back to suffering."

• Ter...
• Taken for less than 1 month
• July 10, 2024

Conjugated estrogens / medroxyprogesterone "I've been taking Prempro for the past month. The first week, my hot flashes got worse, but by week 2, they started to cool off. So far, I like what I'm feeling, but I can't sleep without my fan. I think I'm gaining weight. Today I got my second refill, and I started searching for more info. To be honest, what I read really scared me and made me rethink if I should continue taking it."

• hop...
• Taken for less than 1 month
• November 11, 2022

Conjugated estrogens / medroxyprogesterone "I am just starting on PremPro. My insurance charges over $670 a month due to the deductible. I looked at Canadian pharmacies, and it is a tiny fraction of the price! Everyone, you can Google Canadian pharmacies and get it CHEAPER! Get your doctor to give you a paper prescription, then you can email it to them in Canada! Good luck!"

• Jod...
• Taken for less than 1 month
• September 22, 2022

Conjugated estrogens / medroxyprogesterone "Day 3, and I am floored! My doctor didn't have high hopes that it would help with my depression/anxiety, but it has 100%! I can deal with stresses now. Moisture and sexual attraction have returned. I am sleeping through the night. I am not having moodiness and a short temper. I am able to concentrate and perform daily tasks. There is a mental clarity now. I just feel so well and happy! I am so grateful, I am saved! Side effects so far: mild headache, gas, and constipation. All are easily treatable. I also noticed that my hot flashes have increased a bit. I was managing those pretty well with Estroven, which I am still taking, but for some reason, I am getting them again. If I have to, I will live with them as long as I can continue to feel this peaceful. Aetna denied coverage, saying it isn't medically necessary for me, so I paid out of pocket. I am switching to United Healthcare next month, they cover it as a tier 3, still expensive but $100 vs. $140 out of pocket. Tough on the wallet, but worth it!!!"

• Anonymous
• Taken for 2 to 5 years
• August 4, 2021

Conjugated estrogens / medroxyprogesterone "Had a partial hysterectomy at 43 and went into full menopause. Sweat and felt like my back was on fire and burning pain down to my toes. Was on estrogen for 5 years and it really didn’t help, was put on the highest dose of Prempro about 7 years ago and everything went away. Then my oncologist retired 3 years ago, so my primary wanted me to wean off it, so I started dropping the dosage and was doing great. Then went to the lowest, doing so good I thought in April I could stop it. Boy, not a good idea going on the lowest dose again. Personally, it will be something I will take forever, as long as I can afford it. Cancer does not run in my family, so I feel safe and much happier on this med."

• Deb...
• Taken for less than 1 month
• September 5, 2019

Conjugated estrogens / medroxyprogesterone "Pros: Better mood, sexual functioning back to normal (great!). Cons: Every day terrible bloating, gas, and constipation. On the third week, sudden terrible water retention in legs made walking uncomfortable for me (I'm normally very athletic). I'm not sure if the severe migraine I had 10 days ago was the Prempro or not, but it's suspicious since I had to go in for injections on emergency for the first time from my headache specialist. I plan on NOT taking it in the morning and calling my doctor about the water retention. (I already called regarding the other side effects, but the edema occurred after that phone call today). Anyway, I was going to just ask for either a lower dose or an option a friend recommended (Bijuva). But now, I just want to switch meds altogether. This amount of edema just won't cut it for me!"

• Anonymous
• June 1, 2017

Conjugated estrogens / medroxyprogesterone "I had been on Enjuvia (plus a progesterone supplement) for 3+ years, and they worked fantastic from day one! Unfortunately, they have stopped making it for reasons I can't find. I was put on Divagel, and I gained 15 pounds in 3 weeks, plus the leg (including my foot) I put it on swelled up like a balloon, among other side effects. I have been on Prempro for 6 days now, and my hot flashes/night sweats are worse than ever, but all my other 'problems' seem to be okay. The doctor's office said to give it a month, wish me luck!"

• Kik...
• Taken for 1 to 6 months
• August 10, 2018

Conjugated estrogens / medroxyprogesterone "I was prescribed Prempro by my gynecologist in April 2018. After taking it for one week, my period came, and I had a huge bald spot on the side of my head! I only took it for a week, I stopped, and now here I am, 4 months later, the back of my nape area, my hair is all gone!"

• cyn...
• Taken for less than 1 month
• November 8, 2020

Conjugated estrogens / medroxyprogesterone "I am 52, and I've tried everything for hot flashes, nothing really works, so my GYN tested my prolactin levels. They were pretty high, and that causes hot flashes. I recommend checking prolactin levels. Also, I have tried Prempro, but it made my throat itchy, possible allergic reaction. Anti-anxiety medications helped me with my hot flashes a lot."

• Mrs...
• Taken for less than 1 month
• October 11, 2022

Conjugated estrogens / medroxyprogesterone "I am 47 years old and perimenopausal and have felt horrible before now, day 2 of using Prempro. I was in constant PMS, heavy bleeding, mood swings, and depression. Yippee, the bleeding has stopped and feels like the weight of the world is off my back."

• Ano...
• Taken for 1 to 6 months
• January 1, 2025

Conjugated estrogens / medroxyprogesterone "I’m 54 and have been experiencing menopausal symptoms since I turned 50. After 4 years of suffering from hot flashes, night sweats, sleep deprivation, and worsening vaginal dryness/discomfort, I decided to start Prempro at the lowest dose. I’ve been on it now for about 6 months. After 2 weeks of taking it, my hot flashes and night sweats were completely gone. It was truly amazing. My sleep and my vaginal symptoms improved too. However, after about 3 - 3 1/2 months of taking it, I noticed significant hair loss. I thought my body just needed more time to adjust, so I kept taking it and my hair kept falling out, and it didn’t let up. It’s become so thin. Now I’m in the process of weaning off of Prempro because I don’t want to go bald. It’s so depressing because it was helping me in every other way. But it’s either go bald and feel good or keep my hair and feel horrible. Again, depressing."

• no...
• Taken for less than 1 month
• April 7, 2015

Conjugated estrogens / medroxyprogesterone "Premphase was awesome at controlling my postmenopausal symptoms, especially the hot flashes and night sweats. It works great with not any bad side effects like some of the other ones that I tried. Premphase worked when I had tried everything else to feel normal again."

• Bay...
• Taken for 1 to 6 months
• August 28, 2016

Conjugated estrogens / medroxyprogesterone "Excellent medicine at treating hot flashes, vaginal dryness, and night sweats, but I had a significant weight gain (12 pounds in three months). In addition, I had infrequent bowel movements, larger breasts, bloating, and painful, though predictive periods."

• Anonymous
• Taken for 6 months to 1 year
• February 21, 2022

Conjugated estrogens / medroxyprogesterone "Have been on Prempro for almost a year. Did help with the hot flashes. I do experience a lot of headaches. I have also had a lot of hair loss since taking this. Just got a letter from my pharmacy saying they will no longer pay for Prempro and giving me covered alternatives, such as Estradiol-norethindrone acetate, Fyavolv, Jinteli, Mimvey, and norethindrone-ethin estradiol. Does anyone take any of these HRT alternatives? If so, what is your experience? Also, has anyone had hair loss from Prempro or any other HRTs?"

• Deb...
• Taken for 10 years or more
• June 1, 2024

"I started taking this drug in 1995. I’m now age 70. Over the years, I have reduced the dosage dramatically. My doctor prescribed the 0.625 dosage, and I use a pill cutter to cut it into fourths, which is equivalent to a 0.15625 dosage. This also reduces the cost significantly. I’m sure the drug company would say this is an absolute no-no, but it has worked for me for over 15 years now. My problem is that now no doctors will prescribe this medication for me. They say I shouldn’t still be taking Prempro at my age. I have absolutely no side effects from this medication, and they continually want to put me on Gabapentin to control hot flashes, which has many adverse side effects. I fail to see the logic in this thinking. So now I am dealing with sleepless nights and severe hot flashes."

• Anonymous
• Taken for 1 to 6 months
• January 13, 2022

Conjugated estrogens / medroxyprogesterone "Doctor had me on Premarin for a year, worked great. Doctor then switched me to Prempro. Only took for a month and a half, was having leg cramps and a period after no period for 5 years. I’ll try a supplement instead."

• T-N...
• Taken for less than 1 month
• September 21, 2021

Conjugated estrogens / medroxyprogesterone "Works great, transitioned to it from progesterone and estradiol and didn't notice any changes. The progesterone made me feel drunk, and I slept a little better. I still sleep a lot better than before HRT. I was waking up drenched with sweat and heat and then so cold after the flash."

• Luv...
• Taken for 5 to 10 years
• February 13, 2020

"I started taking Prempro in 2014. This pill literally saved me. I started having hot flashes and night sweats at 32. I used to have at least 2 hot flashes an hour. Hardly ever got 4 hours of sleep at night from flashing and sweating. Didn’t want to go anywhere because I was embarrassed when people commented on my face looking all sweaty. I have tried so many different remedies that did little to stop the flashes. So, when I was prescribed this pill, within two weeks I had my first full night of sleep. Hot flashes had eased up until they were gone. I went to my doctor and gave him a big hug, and I cried. (Never thought the flashes could be stopped). I lost my pills on vacation and had to go 3 weeks before I could get them refilled. Within the second week, I started having flashes. I really can’t survive without this pill, but after 6 years, I am starting to notice some of the side effects getting worse now. Would like to know if there are ways to counteract any of the side effects."

• Bel...
• April 24, 2025

Conjugated estrogens / medroxyprogesterone "Yes, I have started taking Prempro about a week ago. This medication does not take long to see the symptoms of your hot flashes decrease, and sleeping habits are better. If you are not seeing any symptom change, you may need to up the mgs from 1.0 mg to 2.5 mg."