Wellbutrin and Anxiety: What Users Say

• Wel...
• Taken for less than 1 month
• May 1, 2025

For Depression "Felt great but made me jittery and raised my blood pressure, so doctor took me off it."

• Ron...
• Taken for less than 1 month
• March 12, 2025

For Depression "This medication was very hard to use, there was stomach pain and acid reflux. Sleep was poor, and I couldn't sleep more than 2 hours without waking at night. I became very agitated with anxiety and sadness that would come and go very fast. The agitation became worse, and I was looking for anything that irritated me to lash out and went into a rage and confronted others. My heart was always around 100 beats when I was at rest. I also had very strange thoughts that worried me I was losing control of my thoughts."

• Lif...
• Taken for less than 1 month
• February 27, 2025

For Depression "Before I started taking Wellbutrin, I was very tired, stressed, had difficulty concentrating, sad, and unmotivated. Within a week of being on 150 mg a day, I felt such a tremendous positive change. I sleep better too. Now I am actually looking forward to the rest of my life instead of dreading it. I feel inspired, more disciplined, and my mood is stable. I hope this medication continues to support me as a method in my toolbox to improve the quality of my life."

• Fin...
• Taken for 2 to 5 years
• September 6, 2024

"I took a dosage of Wellbutrin 150 mg in delayed-release tablets for years. The drug improves motivation, improves overall function and agility of action, and therefore indirectly reduces some anxious thoughts and, on the other hand, seems to increase physical anxiety symptoms. A good cure for depression that includes anxiety and less good for anxiety is primary. Does not cause obesity or impaired libido."

• Anonymous
• December 29, 2023

For Depression "I started to take it. I can cook, exercise, but I feel worried all the time."

• gar...
• Taken for less than 1 month
• August 6, 2023

For Depression "I’m on day 5 of Wellbutrin. I’ve had severe anxiety and depression for the past 10 years, and I’m 26 now. I’ve been hospitalized twice for suicidal feelings. Tried all different kinds of medications for the past 8 years. I had no hope anymore. I switched doctors this week after getting fed up with my old psychiatrist, who I felt didn’t understand me and couldn’t give me the care I needed. My new doctor understands me, and she started me on Wellbutrin this week. The first day of taking Wellbutrin, I felt relief. The fog of hopelessness was lifted, and although my situation is still bad, I now feel like I have the ability to overcome it. Now on day 5, I’m feeling much better, like I can actually focus more on the present moment rather than being stuck in my head. Side effects have included dry mouth, some stomach issues, anxiety, and insomnia. My doctor gave me trazodone to sleep better, which has helped. Please do not lose hope or be scared to try medications. They can help."

• som...
• Taken for less than 1 month
• June 17, 2023

For Depression "I started bupropion 75 mg and was on it for 10 days. The first days, I was agitated and hypervigilant, had problems with driving as everything attracted my attention, and felt a bit more active. I became careless and a bit arrogant. My empathy and people-pleasing behaviors lowered. I could socialize, not feeling inferior. Slowly, the medicine lost effect. The next 10 days were bupropion ER 150 mg. It gave me grave depression, I feel like I am in a cage, extreme depression, and I feel people are all monsters. I still have empathy, but no joy, no happiness, nothing. I can study, and my brain fog is gone. I can focus if I eat something. Now I am on 300 mg bupropion ER. Still very depressed. No joy. My kidneys are starting to hurt, and I have some breathing problems and nasal dripping problems. Super aware of my surroundings, studying is easy. I have lost joy, and I sleep all the time. I have a dull headache. I feel like if I continue, I will have a mental episode."

• Key...
• Taken for 1 to 6 months
• June 13, 2023

For Major Depressive Disorder "I tried this after Prozac, Lexapro, Celexa, Zoloft, and Cymbalta. Worst one. The worst. I've been on 150 XL for a month and a half, and I can't eat without my stomach tensing up and bile going to my stomach. My menstrual cycle is all messed up, I am tired and spacey, I have horrible diarrhea and anxiety, I feel like utter trash. I think I'm done with antidepressants."

• Bea...
• Taken for less than 1 month
• May 30, 2023

For Depression "I was on Wellbutrin for 3 days, and it gave me massive paranoia, anxiety, and felt like I was going crazy. When I was on a walk, I was seeing my brother's face in guys who were walking by. If you are on Wellbutrin and experience anything like this, please get off of it immediately. Everyone is different, this does work well for some. Medication is all about trial and error! They are switching me to Effexor 37.5 mg, and I’m scared, but we will see."

• kit...
• Taken for less than 1 month
• February 20, 2023

For Depression "I started taking Wellbutrin because I am in a fast-paced nursing program. At first, I thought it was working well. It hit me within 30 minutes of taking it. I took it for 3 weeks, and things got worse, I felt so anxious I would cry, and I couldn’t go out because I was panicking so badly. I started to get really bad insomnia and really bad thoughts every second of every day. I stopped taking it, and I am better most days now. Everyone is different, and some things work for some, and for others, it does not."

• Sug...
• Taken for 1 to 6 months
• February 20, 2023

For Depression "I have mixed reviews of this medication. This made me extremely hyper, as if I had 13 cups of coffee, jittery, made my heart beat super fast. I was doing mindless tasks around the house and out of the house, like organizing carts and stuff in the grocery store. It made me happier, but then when it wore off, I had intense anger beyond imaginable. I loved how energetic it made me feel. Oh, and it made my libido skyrocket."

• Anonymous
• January 18, 2023

For Depression "Made me more anxious and couldn’t sleep. Tried 150 mg and 75 mg. Guess I’ll have to try something else now."

• wel...
• Taken for 1 to 6 months
• January 17, 2023

For Depression "Do not take this medication! Caused severe anxiety, panic attacks, bad dreams, racing thoughts. Should be illegal to prescribe this drug."

• col...
• Taken for 6 months to 1 year
• December 22, 2022

For Major Depressive Disorder "Though I was struggling with an intense chemical imbalance (feeling incredibly hopeless/empty/anxious), I avoided meds for a long time, terrified by bad reviews until the amount I struggled through every waking moment of my day made it impossible for me to continue avoiding. Started on 100 mg of bupropion. I remember feeling very weird at first, dissociating on the first day, then sweating, heart palpitations, some anxiety, and my leg randomly shaking (nothing unmanageable). Immediately, depressive feelings were greatly alleviated. Then a month in, all initial symptoms were pretty much gone, though I still had pockets of depression, so I upped my dose to 150 mg XL. Miraculous. I now feel calm, collected, and very content and thankful for my life. The only side effects I still feel are some ear ringing and loss of appetite (not complaining). This was the extra boost of dopamine my brain needed to function like a normal, healthy human brain. Absolutely incredible and so thankful this exists!!"

• Emi...
• Taken for 1 to 6 months
• November 11, 2022

For Depression "If you're anything like me, you're scrolling these reviews, freaking yourself out over the bad reviews. I never wanted to take meds, but I gave them a try because I needed that extra help. Yes, the first two weeks suck. My anxiety skyrocketed, I was irritable, had dry mouth, and really bad brain fog. That's how it's going to be when taking a new powerful drug, your body needs to adapt. To be blunt, you just need to suck it up and push through, knowing these feelings will pass because they do. One day I was suicidal, so if that lasts more than a day or so, then yes, maybe it's not for you. Have a support system, friends or family, it helps a lot. Week 3-5, I felt no change, week 6 rolled around, and I felt GREAT. At peace, motivated, and clear-minded. I started with 100 mg, just went up to 50 mg. In order to heal, you NEED to pair medication with other help like meditation, yoga, exercise, therapy, and a healthy diet. I promise when you put that effort in, amazing things will come your way."

• Sie...
• Taken for less than 1 month
• November 6, 2022

For Depression "I started this because I take 20 mg of Lexapro, but I have fatigue and lethargy with it. Basically, all SSRIs just make me lazy. My doctor said this would help. I only started a week ago, but I’m posting to talk about initial side effects. I prepared myself for the racing heart, anxiety, etc. that everyone says. Trying new meds is usually rough for me, but this one was fine! First day, 0 side effects. Second day, I was a little extra out of breath at the gym, which gave me anxiety, but other than that, I’ve been fine. Hopefully, it helps me once I’m experiencing the full effect of it. I take the extended release, by the way. That one is best to minimize the side effects."

• sha...
• Taken for less than 1 month
• October 31, 2022

"Wellbutrin 150 mg 1x daily for anxiety and ADHD. 1st 4 days I felt cracked out. Jittery in waves, no appetite, a little floaty, more focus but I had to be doing something. Day 5 I'm hungry but I would be okay if I didn't eat. Not jittery anymore. I feel okay. I'm going to wait until 8 weeks to make a decision if it actually helps or not."

• Lil...
• Taken for less than 1 month
• October 10, 2022

For Depression "Wellbutrin helped me. I have been hurting from depression for 5 months, and now after I upped it to 300 mg XL, I am not in pain from depression anymore, which is AWESOME! I wake up way too early, but I hope this is a side effect that will resolve. I also get very anxious 1 hour after taking it, and I hope that resolves, too. Been on it for 6 days. Also on 50 mg Pristiq in the morning and 10 mg Seroquel at night."

• Anonymous
• Taken for 6 months to 1 year
• September 4, 2022

For Depression "It’s worth a try. Easy to come off of. I’ve cold turkey quit many antidepressants. Insomnia will probably be your worst side effect. Sweating, agitation, restlessness, trouble focusing, and even increased depression and anxiety are common too. It’s an NDRI like Ritalin but much weaker and less selective. I think jogging, drinking lots of water, and an energy drink or coffee or two is more effective. Don’t expect much, but it’s definitely better than SSRIs, SNRIs, antipsychotics, etc."

• Rob...
• September 1, 2022

"By far the best antidepressant I've ever tried. The other two were Lexapro and Zoloft. Both left me foggy, and I always felt a bit disconnected from the flow of things, especially socially. Started Wellbutrin, and literally within a couple of days, felt amazing. The first thing I noticed was this excited feeling of wanting to jump out of bed to start the morning. Super motivated to get stuff done, following through on projects. Dancing to music while cleaning the house type of stuff. And it lasted all day. Life changing. Find the right dose for you. It works pretty quickly once dialed in. Note: Before starting Wellbutrin, I had what I would call moderate depression (of the unproductive and slow-moving kind) and a bit of social anxiety. I did have panic attacks, and sometimes I was agitated for no reason. I give Wellbutrin an A+ with gold stars. 10/10."

• Ter...
• Taken for 1 to 2 years
• July 24, 2022

For Major Depressive Disorder "I have taken Wellbutrin twice before and started it again. YOU NEED TO GIVE IT TIME TO WORK!!! People come in here after 3-4 days and have expected a miracle. Your body is getting used to it and will have some side effects at first. THEY GO AWAY!!!! For my first time, I had to get off of it due to breastfeeding, but on it, I felt happier and don’t have anxiety, etc., with it. It was easy to get on as well. My second time, I was happier, pretty much no anxiety, and lost 15 lbs. I don’t remember why I got off it. I had to beg my doctor to put me on it, and he wouldn’t, so I simply found another doctor who listened to me. It’s the best choice for me. I have depression and horrible anxiety. I quit two jobs due to the anxiety. This is my miracle med. We are all different though, but don’t give up so easily. It works! And an added bonus is some weight loss..."

• Anonymous
• Taken for 1 to 6 months
• June 11, 2022

For Depression "Doctor started me on Wellbutrin 150 mg once daily for ADHD and depression, and I must say this drug takes about 3 weeks to start working. At first, I was frustrated but continued taking it. I experience weight loss, a boost of energy, and motivation in my everyday life. I was on 300 mg daily, and it was a little anxiety, fast heart rate at first, then, after a few hours, it goes away. I was told this is normal."

• Stu...
• Taken for less than 1 month
• April 21, 2022

For Depression "This drug made me nuts. I took it for anxiety and depression, and it multiplied the anxiety by a factor of 10. It was like a hand reached down from the sky, grabbed me by the throat, and scared me witless. I could not calm myself down. I felt doomed. I was so scared I became jumpy and angry. Like, furious. The literature all says these symptoms may fade, so I kept taking the pills for 2 weeks until my husband was exhausted by this frantic woman I had become. I stopped cold and felt normal again almost immediately. So don't feel you have to stay with it!"

• Stu...
• Taken for less than 1 month
• April 21, 2022

For Depression "This drug made me nuts. I took it for anxiety and depression, and it multiplied the anxiety by a factor of 10. It was like a hand reached down from the sky, grabbed me by the throat, and scared me witless. I could not calm myself down. I felt doomed. I was so scared I became jumpy and angry. Like, furious. The literature all says these symptoms may fade, so I kept taking the pills for 2 weeks until my husband was exhausted by this frantic woman I had become. I stopped cold and felt normal again almost immediately. So don't feel you have to stay with it!"

• Bup...
• Taken for 1 to 6 months
• April 19, 2022

For Major Depressive Disorder "It didn't really help at first, until I gave it 6 weeks and my doctor upped my dosage from 150 mg to 300 mg. Everybody is different, I'm just saying what seems to be working for me. I was very suicidal after coming home from the hospital and coming cold turkey off of venlafaxine. I was on an extremely high dose of venlafaxine (375 mg of XL daily) a previous doctor was prescribing. I lost that psychiatrist and because I was extremely psychotic, partially because of the venlafaxine (I think) and had to go to the hospital and be put on Haldol, which has been very effective at treating my psychosis. I am also on buspirone (15 mg daily) and escitalopram. The buspirone is very safe and is helping me, anyways, a great deal with my anxiety. Today, I'm not so sad or nervous as I was a few months ago. I'm sharing what's helping me in hopes that it might help someone out there. Thanks! Sincerely, from someone who has suffered a great deal from chronic depression, psychosis, and generalized anxiety disorder."