Brimonidine / brinzolamide ophthalmic and Dry Mouth: What Users Say

• Rud...
• Taken for 6 months to 1 year
• August 28, 2018

For Glaucoma, Open Angle "SIMBRINZA is effective in a significant reduction to normal ocular pressure. But side effects are terrible. I have lost night vision outside and inside my home. I cannot drive at night because the glare from oncoming vehicles is blinding. I am very sensitive to sunlight. I have blurred vision and loss of acuity. I have muscle pain in my legs and arms. I have a dry mouth. Other side effects include low energy, head pain, eye itching, dizziness, eye comfort, and loss of appetite."

• Pro...
• January 1, 2021

For Glaucoma, Open Angle "The first night that I used Simbrinza, I could hardly walk after about 30 minutes and shuffled off to bed. I use it in the morning at 8:45 am and quite often have to lay down around 9:20 am to have a sleep, which can sometimes last for two hours! I've only had the bad taste in my mouth a couple of times, but I do now struggle with dry mouth, and I must take a bottle of water with me whenever I go out. My eyes are always bloodshot now and often also very red around the eye socket. I've only just learned about the drop in blood pressure from remarks on here, so I will get checked by the doctor next week. Not looking forward to an increase in my girth as it is already much thicker than it should be! I think my long-distance sight is slightly worse but had to tell as I don't do much driving these days - and I certainly don't drive at night if I can help it."

• JPM...
• Taken for 1 to 6 months
• April 24, 2020

For Glaucoma, Open Angle "It was effective for lowering blood pressure (but I use it in conjunction with Lumigan). I take it twice daily in the AM and at bedtime. I have 4 strong side effects listed in increasing order of significance: 1. a strong bitter taste in my mouth that goes away after about an hour. 2. Very dry mouth, especially waking in the AM (I am a mouth breather). 3. Most importantly, I get EXTREMELY DROWSY after taking it in the AM. I am retired, so I can take a deep nap, but it usually lasts for 90 - 120 minutes, so this has had a major impact on my lifestyle. 4. Lower blood pressure, which I have verified with a BP cuff at home. Lower BP also manifests as light-headedness after sleeping. I have had to cut back on my blood pressure meds as a result. I am switching to an alternative."

• Geo...
• Taken for 1 to 6 months
• May 26, 2020

For Glaucoma, Open Angle "After one month's use, have decided to stop these eye drops. I wake up with a dry mouth during the night, causing regular sleep interruption. Therefore, I am already fatigued upon waking, but following the morning drop application, I feel even more tired and lethargic! The dry mouth continues during the day, and I do not leave the house without a bottle of water. My appetite has increased, and I have had rapid weight gain."

• Bar...
• January 5, 2020

For Glaucoma, Open Angle "Hope that all comments are not only what pharma wants to see. Simbrinza is the worst eye drop since I’m taking it for glaucoma. My life changed drastically, red eyes like a tomato, people asking if I smoke marijuana, imagine, and this constant pain like sand in my eyes, dry mouth, and coughing. I'm going to see my doc in March only, I only hope for different drops."

• Chu...
• Taken for less than 1 month
• December 15, 2019

For Intraocular Hypertension "Intraocular pressure went from mid-20s down to 14 after about 10 days of using Simbrinza. The only side effects I've noticed are blurring of vision for about 10-15 minutes after use, dry mouth, and a slight bitter taste in the back of my mouth for 1-3 hours after use, and maybe feeling a little fatigued. Overall, it works well to reduce eye pressure, and side effects have been fairly minimal for me."