Amitriptyline for Persistent Depressive Disorder User Reviews

• Nik...
• Taken for 6 months to 1 year
• December 24, 2012

Amitriptyline "I was taking an SSRI antidepressant and other depression medicines but they didn't work. I started taking this and felt way better than I did before. I've been taking it for a while and got used to the sedating side effects, and it's helped me from the first time I took it."

• Shu...
• Taken for 2 to 5 years
• October 21, 2021

"I have dysthymia and double depression. It started at the age of 20. Before amitriptyline, I took many antidepressants. But they do not work. Amitriptyline saved my life. I don't live with depression at all."

• gca...
• Taken for less than 1 month
• September 12, 2021

"Possibly the best option for persistent depression; after many failed trials with SSRIs, combinations of modern antidepressants, and Seroquel, I was prescribed this tricyclic. In less than 2 days and a low dose of 50 mg, my insomnia and hypersomnia went away. It was shocking because my problems started when I was only 15, and I am now 27. The cost of this disease on me has been gigantic. Failure in university due to the lack of attendance, many course drop-outs due to my depression and fatigue. I was already expecting to live a limited life forever. I persisted in doing my own research and considering all options available. This would be my last antidepressant before ECT. Tricyclics are definitely powerful, and what a shame most doctors are so resistant to prescribing them for those that don't have pre-existing heart problems! These meds are so inexpensive. I am now going to take 75 mg and hoping to stay at this dose, after 2 weeks of taking 50 mg."

• Mis...
• Taken for less than 1 month
• April 7, 2019

"I'd been dealing with depression despite already taking Wellbutrin and Seroquel. I also see a therapist regularly. I've tried many different antidepressants and have had various side effects that made me discontinue them - I am very sensitive to most medications. I suffer from fibromyalgia, IBS, interstitial cystitis, headaches, anxiety, and insomnia on top of the depression. So anyway, I was hopeful that amitriptyline might help at least 1 or 2 of these problems as well. It helped the insomnia, but it caused hypersomnia, and I was sleeping WAY too much. It did nothing for the other conditions. I also noticed that I was getting edgy and irritable with my family, and I'd cry at the drop of a hat. I began experiencing suicidal ideations and realized I needed to stop the medication and see if the amitriptyline was the cause. Within a day, I was already back to baseline. So, yet another medication I cannot take."

• Dam...
• Taken for 6 months to 1 year
• December 21, 2020

Amitriptyline "Very effective on depression and anxiety troubles, yet a lot of side effects. Cured my social anxiety. I tried many antidepressants before, of the SSRI and SSNRI, with low to no results."

• Tas...
• Taken for 6 months to 1 year
• February 1, 2020

"Unfortunately, never had any sedating effects, but feel okay(ish) at 50 mg. Currently titrating up."

• Peg...
• Taken for 1 to 2 years
• October 16, 2018

"I was on this med years ago for a few things. I wasn't told side effect weight gain. I was always thin, and I put on 40 lbs while on it, which made me very depressed."