Epidural Steroid Injection

Medically reviewed by Drugs.com. Last updated on Jun 30, 2025.

• Care notes
• Ambulatory
• Discharge
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An an epidural steroid injection (ESI) is a procedure to inject steroid medicine into the epidural space. The epidural space is between your spinal cord and vertebrae. Steroids may help relieve pain by reducing swelling and inflammation in your spine. You may be given pain medicine along with the steroids.

DISCHARGE INSTRUCTIONS:

Call your local emergency number (911 in the US), or have someone call if:

• You have trouble breathing.
• You have a seizure.
• You have trouble moving your legs.

Seek care immediately if:

• Blood soaks through your bandage.
• You have a fever or chills, severe back pain, and the procedure area is sensitive to the touch.
• You cannot control when you urinate or have a bowel movement.
• You have a severe headache, fever, and a stiff neck.

Related medications

Call your doctor if:

• You have weakness or numbness in your legs.
• Your wound is red, swollen, or draining pus.
• You have nausea or are vomiting.
• Your face or neck is red and you feel warm.
• You have more pain than you had before the procedure.
• You have swelling in your hands or feet.
• You have questions or concerns about your condition or care.

Self-care:

• Care for your procedure area as directed. You may remove the bandage before you go to bed the day of your procedure. You may be able to shower the same day as your procedure. Do not scrub the area. Just let water run over it. Do not take a bath or swim until your healthcare provider says it is okay.
• Apply ice to the procedure area. Ice may reduce pain and swelling. Use an ice pack, or put ice in a plastic bag. Cover the bag with a towel before you apply it. Apply ice to the area for 15 to 20 minutes every hour, or as directed.
• Drink more liquids. Liquids help prevent a headache caused by dehydration and help flush out contrast liquid from your body. Do not drink alcohol. Ask how much liquid to drink each day and which liquids are best for you.
• Ask when you can return to your usual activities. Do not drive, use machines, or do strenuous activity for 24 hours after your procedure or as directed. Do not lift anything heavier than 5 pounds until your provider says it is okay. Your provider will tell you when it is safe for you to return to work, school, or other activities.
• Continue other treatments as directed. You may need to continue other treatments, such as physical therapy to help control your pain.

Follow up with your doctor as directed:

Write down your questions so you remember to ask them during your visits.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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