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Epidural Steroid Injection

Medically reviewed by Drugs.com. Last updated on Jun 30, 2025.

AMBULATORY CARE:

What you need to know about an epidural steroid injection (ESI):

An ESI is a procedure to inject steroid medicine into the epidural space. The epidural space is between your spinal cord and vertebrae. Steroids may help relieve pain by reducing swelling and inflammation in your spine. You may be given pain medicine along with the steroids.

Epidural Steroid Injection

How to prepare for an ESI:

What will happen during an ESI:

What to expect after an ESI:

You will be taken to a room to rest. Healthcare providers will monitor you for any problems. Do not get out of bed until your healthcare provider says it is okay. When healthcare providers see that you are okay, you may be able to go home.

Risks of an ESI:

You may have temporary or permanent nerve damage or paralysis. You may have bleeding or develop a serious infection, such as meningitis (swelling of the brain membranes). An abscess (a pus-filled area under the skin) may develop. You may need surgery to treat the abscess. You may have a seizure, anxiety, or trouble sleeping. The steroid injection may not work and you may still have pain.

Call your local emergency number (911 in the US), or have someone call if:

Seek care immediately if:

Call your doctor if:

Self-care:

Follow up with your doctor as directed:

Write down your questions so you remember to ask them during your visits.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.