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Xylocaine Injection Solution (Anesthetic)

Generic name: Lidocaine Injection Solution (Anesthetic) [ LYE-doe-kane ]
Brand name: Xylocaine
Drug classes: Group I antiarrhythmics, Local injectable anesthetics

Medically reviewed by Last updated on Feb 11, 2023.

Uses of Xylocaine:

  • It is used to numb an area before a procedure.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Xylocaine?

For all uses of Xylocaine (lidocaine injection solution (anesthetic)):

  • If you are allergic to Xylocaine (lidocaine injection solution (anesthetic)); any part of Xylocaine (lidocaine injection solution (anesthetic)); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

Injection (if given into the spine):

  • If you have any of these health problems: Heart block, very bad bleeding, or very bad infection.
  • If you have an infection where the shot will be given.

This is not a list of all drugs or health problems that interact with Xylocaine (lidocaine injection solution (anesthetic)).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Xylocaine (lidocaine injection solution (anesthetic)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Xylocaine?

For all uses of Xylocaine (lidocaine injection solution (anesthetic)):

  • Tell all of your health care providers that you take Xylocaine (lidocaine injection solution (anesthetic)). This includes your doctors, nurses, pharmacists, and dentists.
  • A severe blood problem called methemoglobinemia has happened with drugs like this one. The risk may be raised in people who have glucose-6-phosphate dehydrogenase (G6PD) deficiency, heart problems, or lung problems. The risk may also be raised while taking certain other drugs and in infants younger than 6 months of age. Tell your doctor if you have ever had methemoglobinemia.
  • Avoid driving and doing other tasks or actions that call for you to be alert until the effects of Xylocaine (lidocaine injection solution (anesthetic)) wear off and you feel fully awake.
  • If you are going home before the numbness wears off, protect the treated area from injury until you can feel it again.
  • If you are 65 or older, use Xylocaine (lidocaine injection solution (anesthetic)) with care. You could have more side effects.
  • Use with care in children. Talk with the doctor.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

Injection (if given into the spine):

  • This medicine may cause short-term loss of feeling and motor activity in the lower half of your body. Do not try to get out of bed or do other tasks or actions until feeling and motor activity have returned to normal.


  • Do not eat while your mouth feels numb. You may bite your tongue.

How is this medicine (Xylocaine) best taken?

Use Xylocaine (lidocaine injection solution (anesthetic)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

For all uses of Xylocaine (lidocaine injection solution (anesthetic)):

  • Your doctor will give Xylocaine (lidocaine injection solution (anesthetic)).

Numbing of an area:

  • It is given as a shot.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

For all uses of Xylocaine (lidocaine injection solution (anesthetic)):

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of methemoglobinemia like a blue or gray color of the lips, nails, or skin; a heartbeat that does not feel normal; seizures; very bad dizziness or passing out; very bad headache; feeling very sleepy; feeling tired or weak; or shortness of breath. This effect is rare but may be deadly if it happens.
  • Signs of too much acid in the blood (acidosis) like confusion; fast breathing; fast heartbeat; a heartbeat that does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; or feeling very tired or weak.
  • Trouble breathing, slow breathing, or shallow breathing.
  • Feeling lightheaded, sleepy, confused, or having blurred eyesight.
  • Slow heartbeat.
  • Feeling nervous and excitable.
  • A burning, numbness, or tingling feeling that is not normal.
  • Restlessness.
  • Anxiety.
  • Change in eyesight.
  • Ringing in ears.
  • Dizziness or passing out.
  • Very bad headache.
  • Twitching.
  • Shakiness.
  • Seizures.
  • Feeling hot or cold.
  • Chest pain.
  • Mood changes.

Injection (if given into the spine):

  • Not able to get or keep an erection.
  • Not able to move.
  • Not able to control stools or urine.
  • Trouble passing urine.

What are some other side effects of Xylocaine?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Xylocaine?

  • If you need to store Xylocaine (lidocaine injection solution (anesthetic)) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Xylocaine (lidocaine injection solution (anesthetic)), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.