Generic Name: Protriptyline (proe TRIP ti leen)
Medically reviewed by Drugs.com. Last updated on Sep 9, 2020.
- Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The risk may be greater in people who have had these thoughts or actions in the past. All people who take protriptyline need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
- This medicine is not approved for use in children. Talk with the doctor.
Uses of Protriptyline:
- It is used to treat low mood (depression).
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Protriptyline?
- If you have an allergy to protriptyline or any other part of protriptyline.
- If you are allergic to protriptyline; any part of protriptyline; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have had a recent heart attack.
- If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
- If you are taking any of these drugs: Linezolid or methylene blue.
- If you are taking cisapride.
This is not a list of all drugs or health problems that interact with protriptyline.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take protriptyline with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Protriptyline?
- Tell all of your health care providers that you take protriptyline. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how protriptyline affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- If you have been taking protriptyline for many weeks, talk with your doctor before stopping. You may want to slowly stop protriptyline.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- Tell your doctor if you have signs of high or low blood sugar like breath that smells like fruit, dizziness, fast breathing, fast heartbeat, feeling confused, feeling sleepy, feeling weak, flushing, headache, more thirsty or hungry, passing urine more often, shaking, or sweating.
- Talk with your doctor if you have seizures or have ever had seizures.
- Some people may have a higher chance of eye problems with protriptyline. Your doctor may want you to have an eye exam to see if you have a higher chance of these eye problems. Call your doctor right away if you have eye pain, change in eyesight, or swelling or redness in or around the eye.
- This medicine may make you sunburn more easily. Use care if you will be in the sun. Tell your doctor if you sunburn easily while taking this drug.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- If you are 65 or older, use protriptyline with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using protriptyline while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Protriptyline) best taken?
Use protriptyline as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Keep taking protriptyline as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Feeling confused.
- A heartbeat that does not feel normal.
- Feeling very tired or weak.
- Fever or chills.
- Chest pain or pressure or a fast heartbeat.
- Hallucinations (seeing or hearing things that are not there).
- Trouble controlling body movements.
- Any unexplained bruising or bleeding.
- Yellow skin or eyes.
- Sweating a lot.
- Ringing in ears.
- A burning, numbness, or tingling feeling that is not normal.
- Very bad constipation.
- Very bad belly pain.
- Trouble passing urine.
- Not able to get or keep an erection.
- Change in sex interest.
- Enlarged breasts.
- Nipple discharge.
- Hair loss.
What are some other side effects of Protriptyline?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Dry mouth.
- Upset stomach or throwing up.
- Not able to sleep.
- Bad dreams.
- Feeling sleepy.
- Feeling tired or weak.
- Not hungry.
- Change in taste.
- Mouth irritation or mouth sores.
- Stomach cramps.
- Weight gain or loss.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Protriptyline?
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time protriptyline is refilled. If you have any questions about protriptyline, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about protriptyline
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 2 Reviews
- Drug class: tricyclic antidepressants
- FDA Alerts (1)
Other brands: Vivactil