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Netupitant and palonosetron

Generic Name: netupitant and palonosetron (net-UE-pi-tant & PAL-oh-NOE-se-tron)
Brand Name: Akynzeo

Netupitant and palonosetron is used for:

Preventing nausea and vomiting caused by cancer chemotherapy.

Netupitant and palonosetron is a substance P/neurokinin 1 (NK1) and 5-HT3 receptor blocker combination. It works by blocking the action of certain substances in parts of the brain and nervous system, which helps reduce or prevent nausea and vomiting.

Do NOT use netupitant and palonosetron if:

  • you are allergic to any ingredient in netupitant and palonosetron
  • you have severe kidney or liver problems
  • you are taking rifampin

Contact your doctor or health care provider right away if any of these apply to you.

Before using netupitant and palonosetron:

Some medical conditions may interact with netupitant and palonosetron. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to other 5-HT3 receptor antagonists (eg, ondansetron)

Some MEDICINES MAY INTERACT with netupitant and palonosetron. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) or serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine) because the risk of a severe and sometimes fatal effect (serotonin syndrome) may be increased
  • Rifampin because it may decrease netupitant and palonosetron's effectiveness
  • Benzodiazepines (eg, alprazolam, triazolam), cyclophosphamide, docetaxel, etoposide, ifosfamide, imatinib, irinotecan, paclitaxel, vinblastine, vincristine, or vinorelbine because the risk of their side effects may be increased by netupitant and palonosetron

This may not be a complete list of all interactions that may occur. Ask your health care provider if netupitant and palonosetron may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use netupitant and palonosetron:

Use netupitant and palonosetron as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with netupitant and palonosetron. Talk to your pharmacist if you have questions about this information.
  • Take netupitant and palonosetron by mouth with or without food.
  • Take netupitant and palonosetron about 1 hour before the start of chemotherapy.
  • If you are taking another medicine called dexamethasone along with netupitant and palonosetron, be sure to take it as your doctor has told you.
  • If you miss a dose of netupitant and palonosetron, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use netupitant and palonosetron.

Important safety information:

  • Serotonin syndrome is a possibly fatal syndrome that can be caused by netupitant and palonosetron. Your risk may be greater if you take netupitant and palonosetron with certain other medicines (eg, certain medicines used to treat depression, pain, migraines). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using netupitant and palonosetron while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while you are using netupitant and palonosetron.

Possible side effects of netupitant and palonosetron:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; headache; skin redness; tiredness; upset stomach; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of netupitant and palonosetron:

Store netupitant and palonosetron at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep netupitant and palonosetron out of the reach of children and away from pets.

General information:

  • If you have any questions about netupitant and palonosetron, please talk with your doctor, pharmacist, or other health care provider.
  • Netupitant and palonosetron is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take netupitant and palonosetron or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about netupitant and palonosetron. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to netupitant and palonosetron. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using netupitant and palonosetron.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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