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Netupitant / Palonosetron Dosage

Applies to the following strengths: 300 mg-0.5 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

Highly Emetogenic Chemotherapy, Including Cisplatin Based Chemotherapy:
-Day 1: One capsule (300 mg netupitant/0.5 mg palonosetron) orally approximately 1 hour prior to the start of chemotherapy along with 12 mg dexamethasone orally 30 minutes prior to chemotherapy
-Days 2 to 4: One capsule (300 mg netupitant/0.5 mg palonosetron) orally approximately 1 hour prior to the start of chemotherapy along with 8 mg dexamethasone orally once a day

Anthracyclines, Cyclophosphamide Based Chemotherapy, and Chemotherapy Not Considered Highly Emetogenic:
-Day 1: One capsule (300 mg netupitant/0.5 mg palonosetron) orally approximately 1 hour prior to the start of chemotherapy along with 12 mg dexamethasone orally 30 minutes prior to chemotherapy
-Days 2 to 4: One capsule (300 mg netupitant/0.5 mg palonosetron) orally approximately 1 hour prior to the start of chemotherapy; dexamethasone administration not necessary

Comments:
-Can be taken with or without food

Use: Prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy

Renal Dose Adjustments

Mild to moderate renal impairment: No adjustment recommended
Severe renal impairment or end-stage renal disease: Not recommended

Liver Dose Adjustments

Mild to moderate hepatic impairment (Child-Pugh score 5 to 9): No adjustment recommended
Severe hepatic impairment (Child-Pugh score greater than 9): Not recommended

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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