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Netupitant / Palonosetron Dosage

Applies to the following strength(s): 300 mg-0.5 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

Highly Emetogenic Chemotherapy, Including Cisplatin Based Chemotherapy:
-Day 1: One capsule (300 mg netupitant/0.5 mg palonosetron) orally approximately 1 hour prior to the start of chemotherapy along with 12 mg dexamethasone orally 30 minutes prior to chemotherapy
-Days 2 to 4: One capsule (300 mg netupitant/0.5 mg palonosetron) orally approximately 1 hour prior to the start of chemotherapy along with 8 mg dexamethasone orally once a day

Anthracyclines, Cyclophosphamide Based Chemotherapy, and Chemotherapy Not Considered Highly Emetogenic:
-Day 1: One capsule (300 mg netupitant/0.5 mg palonosetron) orally approximately 1 hour prior to the start of chemotherapy along with 12 mg dexamethasone orally 30 minutes prior to chemotherapy
-Days 2 to 4: One capsule (300 mg netupitant/0.5 mg palonosetron) orally approximately 1 hour prior to the start of chemotherapy; dexamethasone administration not necessary

Comments:
-Can be taken with or without food

Use: Prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy

Renal Dose Adjustments

Mild to moderate renal impairment: No adjustment recommended
Severe renal impairment or end-stage renal disease: Not recommended

Liver Dose Adjustments

Mild to moderate hepatic impairment (Child-Pugh score 5 to 9): No adjustment recommended
Severe hepatic impairment (Child-Pugh score greater than 9): Not recommended

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

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