Generic Name: Neratinib (ne RA ti nib)
Brand Name: Nerlynx
Medically reviewed on Sep 5, 2018
Uses of Nerlynx:
- It is used to treat breast cancer.
What do I need to tell my doctor BEFORE I take Nerlynx?
- If you have an allergy to Nerlynx (neratinib) or any part of Nerlynx (neratinib).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are taking any of these drugs: Dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, or rabeprazole.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Nerlynx (neratinib), like certain drugs that are used for HIV, infections, or seizures. There are many drugs that must not be taken with Nerlynx (neratinib).
- If you are taking St. John's wort. Do not take St. John's wort with Nerlynx (neratinib). This medicine may not work as well.
- If you are breast-feeding. Do not breast-feed while you take Nerlynx (neratinib) or for 1 month after you stop Nerlynx (neratinib).
This is not a list of all drugs or health problems that interact with Nerlynx (neratinib).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Nerlynx (neratinib) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Nerlynx?
- Tell all of your health care providers that you take Nerlynx (neratinib). This includes your doctors, nurses, pharmacists, and dentists.
- It is common to have diarrhea, upset stomach, throwing up, or stomach pain with Nerlynx (neratinib). Call your doctor if any of these side effects get very bad, bother you, or do not go away.
- Sometimes, diarrhea has been very bad with Nerlynx (neratinib). This has led to other health problems like fluid loss, low blood pressure, and kidney problems. Talk to your doctor.
- You will need to take another drug called loperamide and do other things to help with diarrhea. Follow what your doctor has told you to do. Ask your doctor or pharmacist if you are not sure what to do.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Avoid grapefruit and grapefruit juice.
- If you are taking digoxin, talk with your doctor. You may need to have your blood work checked more closely while you are taking it with Nerlynx (neratinib).
- If you are 65 or older, use Nerlynx (neratinib) with care. You could have more side effects.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 3 months after care ends. Use birth control that you can trust.
- If you are a man and your sex partner gets pregnant while you take Nerlynx (neratinib) or within 3 months after your last dose, call your doctor right away.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting Nerlynx (neratinib). Talk with your doctor.
- Use birth control that you can trust to prevent pregnancy while taking Nerlynx (neratinib) and for 1 month after stopping Nerlynx (neratinib).
- If you get pregnant while taking Nerlynx (neratinib) or within 1 month after your last dose, call your doctor right away.
How is this medicine (Nerlynx) best taken?
Use Nerlynx (neratinib) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take Nerlynx (neratinib) with food.
- Take Nerlynx (neratinib) at the same time of day.
- Swallow whole. Do not chew, break, or crush.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- Take Nerlynx (neratinib) at least 3 hours after antacids.
- Do not take cimetidine, famotidine, nizatidine, or ranitidine at the same time as Nerlynx (neratinib). Take Nerlynx (neratinib) at least 2 hours before or 10 hours after taking these drugs.
- To gain the most benefit, do not miss doses.
- Keep taking Nerlynx (neratinib) as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
- More than 2 bowel movements in 1 day.
- Very loose stools (diarrhea).
- Loose stools (diarrhea) that will not go away.
- Swelling of belly.
What are some other side effects of Nerlynx?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling tired or weak.
- Mouth irritation or mouth sores.
- Not hungry.
- Muscle spasm.
- Change in nails.
- Dry skin.
- Weight loss.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Nerlynx?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Nerlynx (neratinib), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Nerlynx (neratinib)
- Nerlynx Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 5 Reviews
- Drug class: EGFR inhibitors