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Nerlynx Side Effects

Generic Name: neratinib

Note: This document contains side effect information about neratinib. Some of the dosage forms listed on this page may not apply to the brand name Nerlynx.

For the Consumer

Applies to neratinib: oral tablet

Along with its needed effects, neratinib (the active ingredient contained in Nerlynx) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking neratinib:

More common Less common
  • Confusion
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • increase in heart rate
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • thirst
  • unusual tiredness or weakness
  • wrinkled skin
  • Bloody urine
  • increased blood pressure
  • increased thirst
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • loss of appetite
  • lower back or side pain
  • nausea
  • raised, firm, bright red patches of skin on the arm or leg
  • stomach pain
  • swelling of the face, fingers, or lower legs
  • troubled breathing
  • vomiting
  • weight gain

Some side effects of neratinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Belching
  • bladder pain
  • bloody nose
  • bloody or cloudy urine
  • decreased appetite
  • decreased weight
  • difficult, burning, or painful urination
  • discoloration of the fingernails or toenails
  • dry skin
  • frequent urge to urinate
  • heartburn
  • indigestion
  • muscle spasms
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
Less common
  • Deep cracks, grooves, or lines in the skin
  • dry mouth

For Healthcare Professionals

Applies to neratinib: oral tablet


The most common adverse reactions (more than 5%) were diarrhea, nausea, abdominal pain, fatigue, vomiting, rash, stomatitis, decreased appetite, muscle spasms, dyspepsia, increased AST or ALT, nail disorder, dry skin, abdominal distention, decreased weight, and urinary tract infection.[Ref]


Very common (10% or more): Diarrhea (95%), nausea (43%), abdominal pain (36%), vomiting (26%), stomatitis (14%), dyspepsia (10%)
Common (1% to 10%): Abdominal distention, dry mouth[Ref]


Very common (10% or more): Fatigue (27%)[Ref]


Very common (10% or more): Rash (18%)
Common (1% to 10%): Nail disorder, rash, skin fissures[Ref]


Very common (10% or more): Decreased appetite (12%)
Common (1% to 10%): Decreased weight, dehydration[Ref]


Very common (10% or more): Muscle spasms (11%)[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Increased ALT, increased AST[Ref]


Common (1% to 10%): Epistaxis[Ref]


Frequency not reported: Hypotension[Ref]


Frequency not reported: Renal failure[Ref]


1. "Product Information. Nerlynx (neratinib)." Puma Biotechnology, Inc., Los Angeles, CA.

Some side effects of Nerlynx may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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