Generic Name: epirubicin (EP i ROO bi sin)
Brand Name: Ellence, Pharmorubicin PFS, Pharmorubicin RDF
What is epirubicin?
Epirubicin is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Epirubicin is used to treat breast cancer.
Epirubicin may also be used for purposes not listed in this medication guide.
What is the most important information I should know about epirubicin?
You should not use this medication if you have an untreated or uncontrolled infection, severe liver disease, severe heart problems, or if you have recently had a heart attack.
Epirubicin may cause dangerous effects on your heart. Call your doctor at once if you have chest pain, shortness of breath (even with mild exertion), swelling, or rapid weight gain.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when epirubicin is injected. Call your doctor if you have irritation or skin changes where the injection was given.
Epirubicin can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
Using epirubicin may increase your risk of other types of cancer, such as leukemia.
What should I discuss with my healthcare provider before I receive epirubicin?
Before you are treated with epirubicin, tell your doctor about all other cancer medications and treatments you have received, including radiation.
You should not use this medication if you are allergic to epirubicin or similar medications (Cerubidine, Adriamycin, Idamycin, Novantrone), or if you have:
an untreated or uncontrolled infection (including mouth sores);
severe liver disease;
severe heart problems; or
if you have recently had a heart attack.
To make sure epirubicin is safe for you, tell your doctor if you have:
liver or kidney disease;
bone marrow suppression;
heart disease; or
if you have been treated before with doxorubicin, daunorubicin, epirubicin, idarubicin, or mitoxantrone.
Using epirubicin may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.
Do not use epirubicin if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment.
Use birth control to prevent pregnancy while you are receiving epirubicin, whether you are a man or a woman. Epirubicin use by either parent may cause birth defects.
It is not known whether epirubicin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using epirubicin.
How is epirubicin given?
Epirubicin is injected into a vein through an IV. A healthcare provider will give you this injection.
Epirubicin is usually given together with other cancer medications. You may be given other medications to prevent nausea, vomiting, or infections.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when epirubicin is injected.
If any of this medication accidentally gets on your skin, wash it thoroughly with soap and warm water.
Epirubicin can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your epirubicin injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving epirubicin?
This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Do not receive a "live" vaccine while using epirubicin, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Epirubicin side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have:
feeling short of breath, even with mild exertion;
swelling, rapid weight gain (especially in your face and midsection);
irritation or skin changes where the injection was given;
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fast, slow, or uneven heartbeats;
anxiety, sweating, severe shortness of breath, wheezing, gasping for breath;
chest pain, sudden cough, cough with foamy mucus, rapid breathing, coughing up blood;
lower back pain, blood in your urine, little or no urinating;
numbness or tingly feeling around your mouth, weak pulse, overactive reflexes, confusion, fainting;
muscle weakness, tightness, or contraction;
fever, chills, body aches, flu symptoms, sores in your mouth and throat; or
pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.
Common side effects may include:
hot flashes, missed menstrual periods;
temporary hair loss;
feeling weak or tired;
mild nausea, diarrhea; or
eye redness, puffy eyelids.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Epirubicin dosing information
Usual Adult Dose for Breast Cancer -- Adjuvant:
For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer:
Starting Dose: 100 to 120 mg/m2 by intravenous infusion every 3 to 4 weeks. The total dose may either be given on Day 1 of each cycle or divided equally and given on Days 1 and 8 of each cycle.
What other drugs will affect epirubicin?
Many drugs can interact with epirubicin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with epirubicin, especially:
auranofin or gold injections to treat arthritis;
an antibiotic or antifungal medication;
an antidepressant--amitriptyline, doxepin, clomipramine, desipramine, imipramine, nortriptyline;
birth control pills or hormone replacement therapy;
cholesterol medications--atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin;
heart or blood pressure medicine--amlodipine, atenolol, carvedilol, digoxin, diltiazem, enalapril, labetalol, lisinopril, methyldopa, nifedipine, verapamil, and others;
NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
other cancer medications, especially docetaxel or paclitaxel; or
seizure medications--carbamazepine, divalproex, phenobarbital, phenytoin, valproic acid, and others.
This list is not complete and many other drugs can interact with epirubicin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
More about epirubicin
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: antibiotics/antineoplastics
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about epirubicin.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 4.04.
Date modified: June 01, 2017
Last reviewed: September 29, 2015