Generic Name: busulfan (byoo-SUL-fan)
Brand Name: Myleran
Busulfan tablet may cause severe and persistent bone marrow depression. Discuss any questions or concerns with your doctor.
Busulfan tablet is used for:
Treating the symptoms of chronic myelogenous leukemia.
Busulfan tablet is an alkylating agent. It works by slowing down reproduction and growth of certain white blood cells, which helps the body fight leukemia.
Do NOT use busulfan tablet if:
- you are allergic to any ingredient in busulfan tablet
Contact your doctor or health care provider right away if any of these apply to you.
Before using busulfan tablet:
Some medical conditions may interact with busulfan tablet. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have bone marrow problems, blood problems (eg, porphyria, thalassemia), a head injury, or a history of seizures (eg, epilepsy)
- if you have undergone chemotherapy or radiation or have previously or are currently taking any other medicines for cancer
- if you are overweight
Some MEDICINES MAY INTERACT with busulfan tablet. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Acetaminophen, metronidazole, or itraconazole because they may increase the risk of busulfan tablet's side effects
- Cyclophosphamide because the risk of serious heart side effects may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if busulfan tablet may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use busulfan tablet:
Use busulfan tablet as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Busulfan tablet may be taken with or without food. If nausea or vomiting occurs, it may help to take busulfan tablet on an empty stomach.
- Busulfan tablet works best if it is taken at the same time each day.
- Drinking extra fluids while you are taking busulfan tablet is recommended. Check with your doctor or nurse for instructions.
- If you miss a dose of busulfan tablet, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use busulfan tablet.
Important safety information:
- Tell your doctor or dentist that you take busulfan tablet before you receive any medical or dental care, emergency care, or surgery.
- If nausea, vomiting, or loss of appetite occur, do not stop using your medicine. Ask your doctor, nurse, or pharmacist for ways to lessen these effects.
- Busulfan tablet may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Busulfan tablet may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Do not receive a live vaccine (eg, measles, mumps) while you are taking busulfan tablet. Talk with your doctor before you receive any vaccine.
- Busulfan tablet increases the risk of a second cancer in future years. It may also cause a rare but serious lung problem (bronchopulmonary dysplasia with pulmonary fibrosis) within months to years after treatment with busulfan tablet. Talk with your doctor if you have questions about your risk for these problems.
- A serious and sometimes fatal heart problem has happened with some people taking busulfan tablet. Most of the time, stomach pain and vomiting happened before the heart problem. Discuss any questions or concerns with your doctor.
- Serious and sometimes fatal liver problems have happened with busulfan tablet. Call your doctor right away if you have symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, right-upper stomach pain, unusual tiredness, yellowing of the skin or eyes).
- Use birth control that you can trust to prevent pregnancy during care and for some time after care ends. Talk with your doctor to see how long to use birth control after you stop busulfan tablet.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for some time after care ends. Use birth control that you can trust. Talk with your doctor to see how long to use birth control after you stop busulfan tablet.
- Busulfan tablet may cause you to not able to get pregnant. Discuss any questions or concerns with your doctor.
- Busulfan tablet may affect sperm in men. This may affect being able to father a child. Discuss any questions or concerns with your doctor.
- Lab tests may be performed while you use busulfan tablet. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- PREGNANCY and BREAST-FEEDING: Busulfan tablet may cause harm to the fetus. Avoid becoming pregnant while you are taking busulfan tablet. If you suspect you may be pregnant, contact your doctor right away. It is unknown if busulfan tablet is excreted in breast milk. Do not breast-feed while taking busulfan tablet.
Possible side effects of busulfan tablet:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Change in color of skin; dry mouth, nose, and throat.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or pressure; missed menstrual period; seizures; severe or persistent nausea, stomach pain, or vomiting; symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or that get bigger; any bleeding that is severe or that you cannot stop); symptoms of infection (eg, fever, chills, sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, painful urination, mouth sores, wound that will not heal, anal itching or pain); symptoms of lung problems (eg, shortness of breath or other trouble breathing, cough, fever); unusual tiredness or weakness; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of busulfan tablet:
Store busulfan tablet at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep busulfan tablet out of the reach of children and away from pets.
- If you have any questions about busulfan tablet, please talk with your doctor, pharmacist, or other health care provider.
- Busulfan tablet is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take busulfan tablet or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about busulfan tablet. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to busulfan tablet. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using busulfan tablet.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about busulfan
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
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- Drug class: alkylating agents