Skip to main content

Busulfan Dosage

Medically reviewed by Drugs.com. Last updated on Apr 25, 2023.

Applies to the following strengths: 2 mg; 6 mg/mL

Usual Adult Dose for Chronic Myelogenous Leukemia


Comments:

Use: For the palliative treatment of chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia

Usual Adult Dose for Bone Marrow Transplantation

0.8 mg/kg ( ideal body weight or actual body weight, whichever is lower) IV via a central venous catheter as a 2-hour infusion every 6 hours for 4 consecutive days for a total of 16 doses (Days 7, 6, 5 and 4) followed by cyclophosphamide 60 mg/kg IV as a 1-hour infusion on each of 2 days beginning no sooner than 6 hours following the sixteenth dose of busulfan (Days 3 and 2); administer hematopoietic progenitor cells on Day 0

Comments:


Use: In combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia (CML)

Usual Pediatric Dose for Chronic Myelogenous Leukemia

60 mcg/kg OR 1.8 mg/m2 orally once a day

Comments:


Use: For the palliative treatment of chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia

Usual Pediatric Dose for Bone Marrow Transplantation

Initial Dose:
Less than or equal to 12 kg: 1.1 mg/kg (based on actual body weight)
Greater than 12 kg: 0.8 mg/kg (based on actual body weight)

Doses are administered every 6 hours as 2-hour infusions over 4 days for a total of 16 doses.

Comments:


Use: In combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia (CML)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Local protocol/standard practice should be consulted. Manufacturer suggested dosing is only a guideline.

For obese or severely obese patients, base dosing of this drug on adjusted ideal body weight (AIBW).

Precautions

US BOXED WARNINGS:


CONTRAINDICATIONS:

Consult WARNINGS section for additional precautions.

Dialysis

This drug is dialyzable; however, no dose adjustment guidelines have been reported.

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.