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Busulfan Dosage

Medically reviewed on December 1, 2017.

Applies to the following strengths: 2 mg; 6 mg/mL

Usual Adult Dose for Chronic Myelogenous Leukemia

-Initial dose: 60 mcg/kg OR 1.8 mg/m2 orally once a day
-The usual adult dose range for remission induction is 4 to 8 mg/day

Comments:
-The dosing presented here is the manufacturer recommended dosing. Local protocol should be consulted.
-Since the rate of fall of the leukocyte count is dose related, daily doses exceeding 4 mg per day should be reserved for patients with the most compelling symptoms; the greater the total daily dose, the greater is the possibility of inducing bone marrow aplasia.
-A decrease in the leukocyte count is not usually seen during the first 10 to 15 days of therapy; the leukocyte count may increase during this period and it should not be interpreted as resistance to the drug, nor should the dose be increased. Since the leukocyte count may continue to fall for more than 1 month after discontinuing the drug, it is important that it be discontinued prior to the total leukocyte count falling into the normal range. When the total leukocyte count has declined to approximately 15,000/mcL, the drug should be withheld.
-With a constant dose of this drug, the total leukocyte count declines exponentially; a weekly plot of the leukocyte count on semi-logarithmic graph paper aids in predicting the time when therapy should be discontinued. With the recommended dose of this drug, a normal leukocyte count is usually achieved in 12 to 20 weeks.
-During remission, the patient should be examined at monthly intervals and therapy resumed with the induction dosage when the total leukocyte count reaches approximately 50,000/mcL.
-When remission is shorter than 3 months, maintenance therapy of 1 to 3 mg orally daily may be advisable to keep the hematological status under control and prevent rapid relapse.

Use: For the palliative treatment of chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia

Usual Adult Dose for Bone Marrow Transplantation

0.8 mg/kg ( ideal body weight or actual body weight, whichever is lower) IV via a central venous catheter as a 2-hour infusion every 6 hours for 4 consecutive days for a total of 16 doses (Days 7, 6, 5 and 4) followed by cyclophosphamide 60 mg/kg IV as a 1-hour infusion on each of 2 days beginning no sooner than 6 hours following the sixteenth dose of busulfan (Days 3 and 2); administer hematopoietic progenitor cells on Day 0

Comments:
-The dosing presented here is the manufacturer recommended dosing. Local protocol should be consulted.
-For obese or severely obese patients, base dosing of this drug on adjusted ideal body weight (AIBW).
-Premedicate with prophylactic anticonvulsant therapy (e.g., phenytoin, levetiracetam, benzodiazepines, or valproic acid) beginning 12 hours prior to high-dose therapy and continuing for 24 hours after the last dose.
-This drug is associated with a moderate emetic potential (depending on dose and/or administration route). Antiemetics may be necessary to prevent nausea and vomiting. Antiemetics are recommended when used for transplantation.
-Administer as IV infusion. Do not administer as an IV push or bolus.

Use: In combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia (CML)

Usual Pediatric Dose for Chronic Myelogenous Leukemia

60 mcg/kg OR 1.8 mg/m2 orally once a day

Comments:
-The dosing presented here is the manufacturer recommended dosing. Local protocol should be consulted.
-Since the rate of fall of the leukocyte count is dose related, daily doses exceeding 4 mg per day should be reserved for patients with the most compelling symptoms; the greater the total daily dose, the greater is the possibility of inducing bone marrow aplasia.
-A decrease in the leukocyte count is not usually seen during the first 10 to 15 days of therapy; the leukocyte count may increase during this period and it should not be interpreted as resistance to the drug, nor should the dose be increased. Since the leukocyte count may continue to fall for more than 1 month after discontinuing the drug, it is important that it be discontinued prior to the total leukocyte count falling into the normal range. When the total leukocyte count has declined to approximately 15,000/mcL, the drug should be withheld.
-With a constant dose of this drug, the total leukocyte count declines exponentially; a weekly plot of the leukocyte count on semi-logarithmic graph paper aids in predicting the time when therapy should be discontinued. With the recommended dose of this drug, a normal leukocyte count is usually achieved in 12 to 20 weeks.
-During remission, the patient should be examined at monthly intervals and therapy resumed with the induction dosage when the total leukocyte count reaches approximately 50,000/mcL.
-When remission is shorter than 3 months, maintenance therapy of 1 to 3 mg orally daily may be advisable to keep the hematological status under control and prevent rapid relapse.

Use: For the palliative treatment of chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia

Usual Pediatric Dose for Bone Marrow Transplantation

Initial Dose:
Less than or equal to 12 kg: 1.1 mg/kg (based on actual body weight)
Greater than 12 kg: 0.8 mg/kg (based on actual body weight)

Doses are administered every 6 hours as 2-hour infusions over 4 days for a total of 16 doses.

Comments:
-Therapeutic drug monitoring and dose adjustment following the first dose of busulfan is recommended.
-Consult the manufacturer product information or local protocol for recommended dose adjustments.

Use: In combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia (CML)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Local protocol/standard practice should be consulted. Manufacturer suggested dosing is only a guideline.

For obese or severely obese patients, base dosing of this drug on adjusted ideal body weight (AIBW).

Precautions

US BOXED WARNINGS:
-This drug is potent. It should not be used unless a diagnosis of chronic myelogenous leukemia has been established and the responsible physician is knowledgeable in assessing response to chemotherapy.
-This drug can induce severe bone marrow hypoplasia. Reduce the dose or discontinue therapy immediately at the first sign of any unusual depression of bone marrow function as reflected by an abnormal decrease in any of the formed elements of the blood. A bone marrow examination should be performed if the bone marrow status is uncertain.

CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients
-In patients in whom a definitive diagnosis of chronic myelogenous leukemia has not been firmly established

Consult WARNINGS section for additional precautions.

Dialysis

This drug is dialyzable; however, no dose adjustment guidelines have been reported.

Other Comments

Administration advice:
-Infusion pumps should be used to administer the diluted IV injection solution. Set the flow rate of the pump to deliver the entire dose over 2 hours.
-Prior to and following each infusion, flush the indwelling catheter line with approximately 5 mL of 0.9% sodium chloride injection or 5% dextrose injection.
-Rapid infusion of the injection has not been tested and is not recommended.

Storage requirements:
-Unopened vials of this drug should be stored under refrigerated conditions between 2C to 8C (36F to 46F).
-Vials diluted with 0.9% sodium chloride injection or 5% dextrose injection are stable at room temperature (25C) for up to 8 hours but the infusion must be completed within that time.
-Vials diluted with 0.9% sodium chloride injection are stable at refrigerated conditions (2C to 8C) for up to 12 hours but the infusion must be completed within that time.
-Store the tablet formulation at 25C (77F); excursions are permitted to 15C to 30C (59 to 86F).

Reconstitution/preparation techniques:
-Skin reactions may occur with accidental exposure. Use gloves when preparing this drug. If the reconstituted IV solution contacts the skin or mucosa, wash the skin or mucosa thoroughly with water.
-Due to incompatibility, do not use any infusion components containing polycarbonate with this drug.
-Visually inspect parenteral drug products for particulate matter and discoloration prior to administration whenever the solution and container permit. Do not use if particulate matter is seen in the vial.
-The IV injection must be diluted prior to infusion with either 0.9% sodium chloride injection or 5% dextrose injection. The diluent quantity should be 10 times the volume of busulfan injection, so that the final concentration of busulfan is approximately 0.5 mg per mL. Consult the manufacturer product information for reconstitution details.
-Do not put the busulfan injection into an IV bag or large-volume syringe that does not contain normal saline or D5W. Always add the busulfan injection to the diluent, not the diluent to the busulfan injection. Mix thoroughly by inverting several times.

IV compatibility:
-The IV formulation of this drug may be reconstituted with 0.9% sodium chloride injection or 5% dextrose injection.
-Do not infuse this drug concomitantly with another IV solution of unknown compatibility.

General:
-This drug is cytotoxic. Follow applicable special handling and disposal procedures.

Monitoring:
-Monitor the patient for myelosuppression.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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