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Asparaginase Erwinia Chrysanthemi

Generic Name: asparaginase (as-PAR-a-jin-ase)
Brand Name: Erwinaze

Asparaginase Erwinia Chrysanthemi is used for:

Treating acute lymphoblastic leukemia (ALL) in certain patients. It is used along with other cancer medicines.

Asparaginase Erwinia Chrysanthemi is an antineoplastic agent. It works by decreasing the amount of asparagine in the body, which kills certain leukemia cells.

Do NOT use Asparaginase Erwinia Chrysanthemi if:

  • you are allergic to any ingredient in Asparaginase Erwinia Chrysanthemi
  • you have ever had serious blood clots, serious bleeding, or pancreatitis after using Asparaginase Erwinia Chrysanthemi or L-asparaginase

Contact your doctor or health care provider right away if any of these apply to you.

Before using Asparaginase Erwinia Chrysanthemi:

Some medical conditions may interact with Asparaginase Erwinia Chrysanthemi. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems, bone marrow problems, diabetes or high blood sugar, or an infection
  • if you have a history of bleeding problems, blood clots, or pancreatitis
  • if you have recently received or are undergoing radiation therapy

Some MEDICINES MAY INTERACT with Asparaginase Erwinia Chrysanthemi. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), aspirin, dipyridamole, heparin, or nonsteroidal anti-inflammatory drugs (NSAIDs) because the risk of bleeding may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Asparaginase Erwinia Chrysanthemi may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Asparaginase Erwinia Chrysanthemi:

Use Asparaginase Erwinia Chrysanthemi as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Asparaginase Erwinia Chrysanthemi is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • If you miss a dose of Asparaginase Erwinia Chrysanthemi, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Asparaginase Erwinia Chrysanthemi.

Important safety information:

  • Tell your doctor or dentist that you take Asparaginase Erwinia Chrysanthemi before you receive any medical or dental care, emergency care, or surgery.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking Asparaginase Erwinia Chrysanthemi. Talk with your doctor before you receive any vaccine.
  • Serious bleeding and blood clots have been reported with the use of Asparaginase Erwinia Chrysanthemi and other similar medicines. Contact your doctor right away if you experience calf, leg, or arm pain, swelling, redness, or tenderness; chest pain; coughing up blood; one-sided weakness; shortness of breath; slurred speech; unusual bruising or bleeding; or vision problems.
  • Asparaginase Erwinia Chrysanthemi may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Diabetes patients - Asparaginase Erwinia Chrysanthemi may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests may be performed while you use Asparaginase Erwinia Chrysanthemi. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Asparaginase Erwinia Chrysanthemi while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Asparaginase Erwinia Chrysanthemi.

Possible side effects of Asparaginase Erwinia Chrysanthemi:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; mild stomach pain or upset; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); calf, leg, or arm pain, swelling, redness, or tenderness; chest pain; confusion; coughing up blood; fever; headache; one-sided weakness; pain, redness, or swelling at the injection site; seizures; shortness of breath; slurred speech; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; drowsiness; flushing; rapid breathing; fruit-like breath odor); symptoms of pancreatitis (eg, severe stomach or back pain with or without nausea or vomiting); unusual bleeding or bruising; vision problems; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately.

Proper storage of Asparaginase Erwinia Chrysanthemi:

Asparaginase Erwinia Chrysanthemi will be handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

General information:

  • If you have any questions about Asparaginase Erwinia Chrysanthemi, please talk with your doctor, pharmacist, or other health care provider.
  • Asparaginase Erwinia Chrysanthemi is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Asparaginase Erwinia Chrysanthemi or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Asparaginase Erwinia Chrysanthemi. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Asparaginase Erwinia Chrysanthemi. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Asparaginase Erwinia Chrysanthemi.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.