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Asparaginase erwinia chrysanthemi recombinant-rywn (Intramuscular)

Generic name: asparaginase erwinia chrysanthemi recombinant-rywn [ as-par-a-JIN-ase-er-WIN-i-a-kris-an-THEM-i-re-KOM-bin-ant-- rywn ]
Brand name: Rylaze
Drug class: Miscellaneous antineoplastics

Medically reviewed by Drugs.com. Last updated on Apr 25, 2024.

Uses for asparaginase erwinia chrysanthemi recombinant-rywn

Asparaginase Erwinia chrysanthemi recombinant-rywn is used together with other cancer medicines to treat certain types of blood cancer called acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). This medicine is used in patients who have had an allergic reaction to E. coli-derived asparaginase.

Asparaginase Erwinia chrysanthemi recombinant-rywn belongs to the group of medicines known as antineoplastic agents. It interferes with the growth of the cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by this medicine, other effects will also occur. Some of these may be serious and must be reported to your doctor.

Before you begin treatment with Rylaze™, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is to be given only by or under the direct supervision of your doctor.

Before using asparaginase erwinia chrysanthemi recombinant-rywn

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Rylaze™ in children younger than 1 month of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies have not been performed on the relationship of age to the effects of Rylaze™ in the geriatric population. Safety and efficacy have not been established.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper use of asparaginase erwinia chrysanthemi recombinant-rywn

A doctor or other trained health professional will give you or your child this medicine in a hospital or cancer treatment center. This medicine is given as a shot into a muscle.

This medicine is usually given every 2 days or on a Monday, Wednesday, and Friday schedule.

Your doctor may also give you other medicines (eg, acetaminophen, an allergy medicine, and a stomach medicine) 30 to 60 minutes before receiving this medicine to help prevent unwanted effects.

Rylaze™ is sometimes given together with other medicines. If you are receiving a combination of medicines, it is important that you or your child receive each one at the proper time. If you are taking some of these medicines by mouth, ask your doctor to help you plan to take them at the right times.

Blincyto, methotrexate, imatinib, doxorubicin, Sprycel, Gleevec, mercaptopurine

Precautions while using asparaginase erwinia chrysanthemi recombinant-rywn

It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control during treatment and for at least 3 months after your last dose to keep from getting pregnant. If you think you have become pregnant, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis or angioedema, which can be life-threatening and require immediate medical attention. Tell your doctor or nurse right away if you or your child have a large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, chills, fever, lightheadedness, dizziness, or fainting, fast, pounding heartbeat, swelling of the face, tongue, and throat, or trouble breathing after you receive the medicine.

Pancreatitis (swelling of the pancreas) may occur during treatment with this medicine. Tell your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Tell your doctor right away if you or your child develop confusion, headache, nausea and vomiting, numbness or tingling in the arms or legs, or chest pain after receiving this medicine. These may be symptoms of a serious bleeding or blood clotting problem.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Side Effects of asparaginase erwinia chrysanthemi recombinant-rywn

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Less common

Incidence not known

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Commonly used brand name(s)

In the U.S.

Available Dosage Forms:

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Asparaginase Erwinia Chrysanthemi Recombinant

Biological Products Related to asparaginase erwinia chrysanthemi

Find detailed information on biosimilars for this medication.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.