Asparaginase Erwinia Chrysanthemi Dosage
Medically reviewed by Drugs.com. Last updated on Mar 23, 2020.
Applies to the following strengths: 10000 intl units
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Acute Lymphoblastic Leukemia
To substitute for a dose of pegaspargase:
25,000 International Units/m2 intramuscularly three times a week (Monday/Wednesday/Friday) for six doses for each planned dose of pegaspargase.
To substitute for a dose of native E. coli asparaginase:
25,000 International Units/m2 administered intramuscularly for each scheduled dose of native E. coli asparaginase within a treatment regimen.
Comments:
-Limit the volume of reconstitution at a single injection site to 2 mL; if reconstituted dose to be administered is greater than 2 mL, use multiple injection sites.
-If a partial vial is used, do not save or reuse the unused drug for later administration. Discard unused portions.
Use:
-Indicated as a component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia (ALL) who have developed hypersensitivity to E. coli-derived asparaginase.
Usual Pediatric Dose for Acute Lymphoblastic Leukemia
To substitute for a dose of pegaspargase:
25,000 International Units/m2 intramuscularly three times a week (Monday/Wednesday/Friday) for six doses for each planned dose of pegaspargase.
To substitute for a dose of native E. coli asparaginase:
25,000 International Units/m2 administered intramuscularly for each scheduled dose of native E. coli asparaginase within a treatment.
Comments:
-Limit the volume of reconstitution at a single injection site to 2 mL; if reconstituted dose to be administered is greater than 2 mL, use multiple injection sites.
-If a partial vial is used, do not save or reuse the unused drug for later administration. Discard unused portions.
Uses:
-Indicated as a component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia (ALL) who have developed hypersensitivity to E. coli-derived asparaginase.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Storage requirements:
-Store unused or unopened vials and cartons at 36F to 46F (2C to 8C).
-Protect from light.
Reconstitution/preparation techniques: The manufacturer product information should be consulted.
Monitoring:
-Monitor glucose levels at baseline and periodically during treatment.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about asparaginase erwinia chrysanthemi
- Side Effects
- During Pregnancy
- Drug Interactions
- En Español
- Drug class: miscellaneous antineoplastics
Consumer resources
- Asparaginase Erwinia chrysanthemi
- Asparaginase erwinia chrysanthemi Intramuscular (Advanced Reading)
Other brands: Erwinaze