Skip to main content


Generic name: asparaginase Erwinia chrysanthemias-PAR-a-jin-ase-er-WIN-ee-a-kri-SAN-the-mee ]
Brand names: Erwinaze, Rylaze
Drug class: Miscellaneous antineoplastics

Medically reviewed by on Jul 8, 2021. Written by Cerner Multum.

What is Rylaze?

Rylaze is a cancer medicine.

Erwinaze is used to treat acute lymphoblastic leukemia in adults and children at least 1 year old.

Rylaze is used to treat lymphoblastic lymphoma in adults and children at least 1 month old who have become allergic to other forms of asparaginase such as Elspar or Oncaspar.

Rylaze may also be used for purposes not listed in this medication guide.


Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use Rylaze if you have received any form of asparaginase in the past and it caused you to have:

  • a serious allergic reaction;

  • serious pancreas problems;

  • a life-threatening blood clot; or

  • serious bleeding problems.

Tell your doctor if you have ever had:

  • problems with your liver or pancreas;

  • bleeding problems;

  • a blood clot; or

  • diabetes.

May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 3 months after your last dose. Tell your doctor if you become pregnant.

Rylaze can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, or contraceptive sponge.

Do not breastfeed while using this medicine, and for at least 3 months after your last dose of Erwinaze or 1 week after your last dose of Rylaze.

How should I use Rylaze?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Rylaze is injected into a muscle or into a vein. Erwinaze is usually given every 48 hours. Rylaze is usually given 3 times per week.

Read and follow all Instructions for Use. Ask your doctor or pharmacist if you need help.

Do not shake the medication bottle or you may ruin the medicine.

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine has changed colors or has particles in it.

Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Your blood will need to be tested often and your dose or medication schedule may be changed based on the results.

Doses are based on body surface area (height and weight). Your dose may change if you gain or lose weight or if you are still growing.

Store this medicine in the original carton in the refrigerator. Protect from light.

Throw away a vial (bottle) after one use, even if there is still medicine left inside.

Store mixed medicine at room temperature and use it within 4 hours. Do not refrigerate or freeze after mixing.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Rylaze?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Rylaze side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Rylaze may cause serious side effects. Call your doctor at once if you have:

  • easy bruising or bleeding (nosebleeds, bleeding gums);

  • any bleeding that will not stop;

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

  • signs of liver or pancreas problems--severe stomach pain (that may spread to your back), nausea or vomiting, jaundice (yellowing of the skin or eyes);

  • signs of a blood clot--sudden numbness or weakness (especially on one side of the body), severe headache, chest pain, feeling short of breath, pain or swelling in an arm or leg;

  • low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough; or

  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Rylaze may include:

  • liver or pancreas problems;

  • bleeding or blood clots;

  • high blood sugar;

  • stomach pain, loss of appetite, nausea, vomiting, diarrhea;

  • fever, headache, tiredness, mouth sores;

  • bone pain, muscle or joint pain;

  • allergic reaction, skin rash; or

  • abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Rylaze?

Other drugs may affect Rylaze, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.