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Asparaginase erwinia chrysanthemi Side Effects

In Summary

Commonly reported side effects of asparaginase erwinia chrysanthemi include: anaphylaxis. Other side effects include: pancreatitis and severe hypersensitivity. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to asparaginase erwinia chrysanthemi: injection powder for solution

Along with its needed effects, asparaginase erwinia chrysanthemi may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking asparaginase erwinia chrysanthemi:

More common
  • Cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever
  • hives or welts, itching, or rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness
Less common
  • Abdominal or stomach pain
  • bloating
  • blurred vision
  • chills
  • constipation
  • dark urine
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • loss of appetite
  • nausea
  • pains in the chest, groin, or legs, especially calves of the legs
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • seizures
  • severe headaches of sudden onset
  • sudden loss of coordination
  • sudden onset of slurred speech
  • sudden vision changes
  • sweating
  • unexplained weight loss
  • vomiting
  • yellow eyes or skin
Rare
  • Blood in the urine or stools
  • bruising
  • confusion
  • coughing or vomiting blood
  • headache
  • numbness or tingling in the face, arms, or legs
  • persistent bleeding or oozing from puncture sites, mouth, or nose
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • trouble speaking, thinking, or walking

Some side effects of asparaginase erwinia chrysanthemi may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Diarrhea

For Healthcare Professionals

Applies to asparaginase erwinia chrysanthemi: injectable powder for injection

General

Most common adverse reactions were systemic hypersensitivity, hyperglycemia, abnormal transaminases, fever, pancreatitis, local reactions, vomiting, nausea, thrombosis, hyperbilirubinemia, abdominal pain/discomfort, and diarrhea.[Ref]

Hypersensitivity

Very common (10% or more): Systemic hypersensitivity (14%)
Very rare (less than 0.01%): Anaphylaxis[Ref]

Gastrointestinal

Common (1% to 10%): Pancreatitis, vomiting, nausea, abdominal pain/discomfort, diarrhea, serum amylases increased, serum lipase increased[Ref]

Nervous system

Common (1% to 10%): Lethargy, somnolence, confusion, dizziness, neurotoxicity, convulsions, headache
Rare (less than 0.1%): Dysphasia, dysphagia, CNS depression, coma[Ref]

Dermatologic

Common (1% to 10%): Rash, urticarial, pruritus, erythema, facial edema[Ref]

Hepatic

Common (1% to 10%): Transaminases abnormal, hyperbilirubinemia, alkaline phosphatase increased, cholesterol increased
Rare (less than 0.1%): Hepatic failure
Frequency not reported: Hepatomegaly, cholestatic jaundice[Ref]

Hematologic

Common (1% to 10%): Hypofibrinogenemia, asymptomatic coagulopathy
Very rare (less than 0.01%): Neutropenia, febrile neutropenia, thrombocytopenia
Frequency not reported: clotting factor decreased, antithrombin III decreased, protein C decreased, protein S decreased, fibrinogen decreased[Ref]

Cardiovascular

Common (1% to 10%): Thrombosis, pallor
Very rare (less than 0.01%): Hemorrhage
Frequency not reported: Hypertension[Ref]

Metabolic

Common (1% to 10%): Hyperglycemia
Uncommon (0.1% to 1%): Hyperlipidemia
Rare (0.01% to 0.1%): Diabetic ketoacidosis
Very rare (less than 0.01%): Hyperammonemia[Ref]

Local

Common (1% to 10%): Local reactions[Ref]

Other

Common (1% to 10%): Fever[Ref]

Musculoskeletal

Very rare (less than 0.01%): Myalgia, reactive arthritis
Frequency not reported: Extremity pain[Ref]

Immunologic

Very rare (less than 0.01%): Life-threatening sepsis[Ref]

References

1. "Product Information. Erwinaze (asparaginase Erwinia chrysanthemi)." EUSA Pharma, Newtown, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of asparaginase erwinia chrysanthemi may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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