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Asparaginase erwinia chrysanthemi Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 30, 2022.

Summary

Commonly reported side effects of asparaginase erwinia chrysanthemi include: anaphylaxis. Other side effects include: pancreatitis and severe hypersensitivity reaction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to asparaginase erwinia chrysanthemi: injection powder for solution

Other dosage forms:

Side effects requiring immediate medical attention

Along with its needed effects, asparaginase erwinia chrysanthemi may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking asparaginase erwinia chrysanthemi:

More common

  • Agitation
  • back pain
  • black, tarry stools
  • bleeding gums
  • bloating
  • blood in the urine or stools
  • blurred vision
  • chest pain
  • chills
  • coma
  • confusion
  • constipation
  • cough or hoarseness
  • difficulty in walking
  • dizziness
  • drooping eyelids
  • drowsiness
  • dry mouth
  • lightheadedness
  • fainting
  • fast heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • hallucinations
  • headache
  • increased hunger
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • increased urination
  • indigestion
  • irritability
  • jaw pain
  • lower back or side pain
  • mood or mental changes
  • nosebleeds
  • numbness or tingling in the fingers and toes
  • pain in the fingers and toes
  • pain in the testicles
  • pains in the chest, groin, or legs, especially calves of the legs
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • painful or difficult urination
  • pale skin
  • paralysis
  • pinpoint red spots on the skin
  • prolonged bleeding from cuts
  • rapid, shallow breathing
  • seizures
  • severe headaches of sudden onset
  • sleepiness or unusual drowsiness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiff neck
  • stomach pain
  • sudden loss of coordination
  • sudden onset of slurred speech
  • sudden vision changes
  • sweating
  • swollen glands
  • trouble breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin

Less common

  • Chest tightness
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • hives, itching, skin rash
  • increase in frequency of seizures
  • loss of appetite
  • loss of consciousness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

Incidence not known

  • Diarrhea
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • unpleasant breath odor
  • vomiting of blood

Side effects not requiring immediate medical attention

Some side effects of asparaginase erwinia chrysanthemi may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to asparaginase erwinia chrysanthemi: injectable powder for injection, intramuscular solution

General

Most common adverse reactions were systemic hypersensitivity, hyperglycemia, abnormal transaminases, fever, pancreatitis, local reactions, vomiting, nausea, thrombosis, hyperbilirubinemia, abdominal pain/discomfort, and diarrhea.[Ref]

Hypersensitivity

Very common (10% or more): Systemic hypersensitivity (14%)

Very rare (less than 0.01%): Anaphylaxis[Ref]

Gastrointestinal

Common (1% to 10%): Pancreatitis, vomiting, nausea, abdominal pain/discomfort, diarrhea, serum amylases increased, serum lipase increased[Ref]

Nervous system

Common (1% to 10%): Lethargy, somnolence, confusion, dizziness, neurotoxicity, convulsions, headache

Rare (less than 0.1%): Dysphasia, dysphagia, CNS depression, coma[Ref]

Dermatologic

Common (1% to 10%): Rash, urticarial, pruritus, erythema, facial edema[Ref]

Hepatic

Common (1% to 10%): Transaminases abnormal, hyperbilirubinemia, alkaline phosphatase increased, cholesterol increased

Rare (less than 0.1%): Hepatic failure

Frequency not reported: Hepatomegaly, cholestatic jaundice[Ref]

Hematologic

Common (1% to 10%): Hypofibrinogenemia, asymptomatic coagulopathy

Very rare (less than 0.01%): Neutropenia, febrile neutropenia, thrombocytopenia

Frequency not reported: clotting factor decreased, antithrombin III decreased, protein C decreased, protein S decreased, fibrinogen decreased[Ref]

Cardiovascular

Common (1% to 10%): Thrombosis, pallor

Very rare (less than 0.01%): Hemorrhage

Frequency not reported: Hypertension[Ref]

Metabolic

Common (1% to 10%): Hyperglycemia

Uncommon (0.1% to 1%): Hyperlipidemia

Rare (0.01% to 0.1%): Diabetic ketoacidosis

Very rare (less than 0.01%): Hyperammonemia[Ref]

Local

Common (1% to 10%): Local reactions[Ref]

Other

Common (1% to 10%): Fever[Ref]

Musculoskeletal

Very rare (less than 0.01%): Myalgia, reactive arthritis

Frequency not reported: Extremity pain[Ref]

Immunologic

Very rare (less than 0.01%): Life-threatening sepsis[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Erwinaze (asparaginase Erwinia chrysanthemi)." EUSA Pharma, Newtown, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.