Asparaginase Erwinia Chrysanthemi Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 11, 2024.

Applies to asparaginase erwinia chrysanthemi: intramuscular solution.

Other dosage forms:

• injection powder for solution

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control during treatment and for at least 3 months after your last dose to keep from getting pregnant. If you think you have become pregnant, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis or angioedema, which can be life-threatening and require immediate medical attention. Tell your doctor or nurse right away if you or your child have a large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, chills, fever, lightheadedness, dizziness, or fainting, fast, pounding heartbeat, swelling of the face, tongue, and throat, or trouble breathing after you receive the medicine.

Pancreatitis (swelling of the pancreas) may occur during treatment with this medicine. Tell your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Tell your doctor right away if you or your child develop confusion, headache, nausea and vomiting, numbness or tingling in the arms or legs, or chest pain after receiving this medicine. These may be symptoms of a serious bleeding or blood clotting problem.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Serious side effects

Along with its needed effects, asparaginase erwinia chrysanthemi may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking asparaginase erwinia chrysanthemi:

Other side effects

Some side effects of asparaginase erwinia chrysanthemi may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

See also:

For healthcare professionals

Applies to asparaginase erwinia chrysanthemi: injectable powder for injection, intramuscular solution.

General adverse events

The most frequent nonhematological serious adverse reactions (in greater than 5% of patients) were febrile neutropenia, infection, drug hypersensitivity, pyrexia, nausea, dehydration, stomatitis, acute kidney injury, pancreatitis, diarrhea, and viral infection.^[Ref]

Hypersensitivity

• Very common (15% or more): Hypersensitivity reactions including rash, infusion related reaction, lip swelling, periorbital edema, throat irritation, urticaria, dry skin, eczema, erythema, hand dermatitis, rash maculo-papular, rash papular (21% to 24%)
• Very rare (less than 0.01%): Anaphylaxis^[Ref]

Gastrointestinal

• Very common (15% or more): Stomatitis (24% to 27%), nausea (45% to 47%), abdominal pain (21% to 25%), diarrhea (18% to 25%), pancreatitis (12% to 22%)^[Ref]

Nervous system

• Very common (15% or more): Headache (22% to 36%), peripheral neuropathy including peripheral motor neuropathy, neuropathy peripheral, peripheral sensory neuropathy (6% to 15%)^[Ref]

Dermatologic

• Common (1% to 10%): Rash (19%)
• Frequency not reported: Toxic epidermal necrosis^[Ref]

Hepatic

• Very common (15% or more): Abnormal liver tests (70% to 75%)
• Frequency not reported: Hepatomegaly, cholestatic jaundice^[Ref]

Hematologic

• Very common (15% or more): Febrile neutropenia (27% to 30%), hemorrhage including contusion, epistaxis, catheter site hemorrhage, petechiae, hematochezia, menorrhagia, mouth hemorrhage, increased tendency to bruise, rectal hemorrhage (24 to 27%)
• Frequency not reported: clotting factor decreased, antithrombin III decreased, protein C decreased, protein S decreased, fibrinogen decreased^[Ref]

Cardiovascular

• Very common (reported as 15% or more): Tachycardia (16 to 18%)^[Ref]

Metabolic

• Very common (15% or more): Hyperglycemia (12% to 21%), hypokalemia (9% to 22%, dehydration (12% to 15%), decreased appetite (21% to 27%)
• Rare (0.01% to 0.1%): Diabetic ketoacidosis
• Very rare (less than 0.01%): Hyperammonemia^[Ref]

Other

Infections:

• Very common (15% or more): Including sepsis, upper respiratory tract infection, enterocolitis infectious, skin infection, bacteremia, paronychia, pneumonia, otitis externa, soft tissue infection, abdominal infection, conjunctivitis, device related infection, folliculitis, lymph gland infection, necrotizing fasciitis, perirectal abscess, peritonsillar abscess, sinusitis, subcutaneous abscess, wound infection (27% to 36%)^[Ref]

Musculoskeletal

• Very common (15% or more): Musculoskeletal pain, including arthralgia, back pain, musculoskeletal chest pain, musculoskeletal pain, myalgia, pain in extremity (35% to 45%)^[Ref]

Psychiatric

• Very common (15% or more): Insomnia (4% to 15%)^[Ref]

Respiratory

• Very common (15% or more): Cough (15%)^[Ref]

Further information

Asparaginase erwinia chrysanthemi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer