Voquezna Dual Pak

Generic name: amoxicillin and vonoprazan
Dosage form: co-packaged capsules and tablets
Drug class: H. pylori eradication agents

Medically reviewed by Judith Stewart, BPharm. Last updated on Aug 23, 2022.

What is Voquezna Dual Pak?

Voquezna Dual Pak is a treatment regimen containing an antibiotic and an acid blocker for the treatment of Helicobacter pylori (H. pylori) infection in adults.

H. pylori is a bacteria that can infect the lining of the stomach and upper intestine. H. pylori infection is a common cause of stomach ulcers (peptic ulcers).

Voquezna Dual Pak contains amoxicillin capsules and vonoprazan tablets. Amoxicillin is an antibiotic, and vonoprazan is a potassium-competitive acid blocker (PCAB) that blocks acid secretion in the stomach.

Warnings

Voquezna Dual Pak can cause serious allergic reactions. Get emergency medical help if you have hives, itching, trouble breathing, swelling in your face or throat, or if you feel light-headed.

The antibiotic medicine contained in Voquezna Dual Pak can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Before taking this medicine

You should not use this medicine if you are allergic to amoxicillin (Amoxil) or vonoprazan, or if:

you have had a severe allergic reaction to a penicillin antibiotic, including ampicillin, dicloxacillin, oxacillin, penicillin, and ticarcillin; or
you are taking any HIV medicine that contains rilpivirine (Cabenuva, Complera, Edurant, Juluca, or Odefsey).

Tell your doctor if you have:

liver disease;
kidney disease;
mononucleosis (also called "mono");
allergies.

It is not known if this medicine may harm an unborn baby. Use birth control and tell your doctor if you become pregnant.

Breastfeeding is not recommended during treatment, but a lactating woman can pump and discard breast milk during the 14-day course of treatment and for 2 days after.

Voquezna Dual Pak is not approved for use by anyone younger than 18 years old.

How should I take Voquezna Dual Pak?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

This combination medicine contains amoxicillin 500 mg capsules and vonoprazan 20 mg tablets.

The recommended dosage regimen is two amoxicillin 500 mg capsules three times a day (morning, mid-day, and evening) and one vonoprazan 20 mg tablet twice daily (morning and evening).

The dose is given with or without food, for 14 days.

Swallow each pill whole and do not crush, chew, break, or open it.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication.

Store at room temperature, away from moisture, heat, and light.

Dosing Information

Usual Adult Dose for Helicobacter pylori Infection

The recommended dosage regimen is vonoprazan 20 mg twice daily (morning and evening) plus amoxicillin 1000 mg, three times a day (morning, mid-day, and evening), with or without food, for 14 days.

Use: treatment of Helicobacter pylori infection in adults.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Voquezna Dual Pak?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Voquezna Dual Pak side effects

Voquezna Dual Pak can cause serious side effects. Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose).

Common side effects include:

diarrhea;
abdominal pain;
vulvovaginal candidiasis (vaginal yeast infection); and
nasopharyngitis.

What other drugs will affect Voquezna Dual Pak?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines, especially:

any HIV medicine containing rilpivirine (Cabenuva, Complera, Edurant, Juluca, or Odefsey).

This list is not complete and many other drugs may affect Voquezna Dual Pak. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

How should I store Voquezna Dual Pak?

Store Voquezna Dual Pak at room temperature between 68°F to 77°F (20°C to 25°C).

Store in a dry place away from moisture.

Keep all medicines out of the reach of children and pets.

General information about the safe and effective use of Voquezna Dual Pak

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What are the ingredients in Voquezna Dual Pak?

Amoxicillin 500 mg Capsules

Active Ingredient: amoxicillin trihydrate
Inactive Ingredients:
Capsule shells – ammonium hydroxide, black ferric oxide, gelatin, potassium hydroxide, propylene glycol, shellac, titanium dioxide and yellow ferric oxide.
Capsule contents – cellulose microcrystalline and magnesium stearate.

Vonoprazan 20 mg Tablets

Active Ingredient: vonoprazan fumarate
Inactive Ingredients: croscarmellose sodium, ferric oxide red, fumaric acid, hydroxypropyl cellulose, hypromellose, magnesium stearate, mannitol, microcrystalline cellulose, polyethylene glycol 8000, and titanium dioxide.