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Prednisolone: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 20, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with prednisolone may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with prednisolone. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with prednisolone include:

Prednisolone may increase blood glucose concentrations in people with diabetes and dosage adjustments of antidiabetic agents (eg, insulin, glyburide) may be required. Use of fluoroquinolone antibiotics (such as ciprofloxacin or levofloxacin) may increase the risk of tendon rupture with fluoroquinolones.

In addition, alcohol can increase the likelihood of gastrointestinal side effects with prednisolone, and possibly liver and kidney damage. Prednisolone may suppress the inflammatory response to skin tests.

Note that this list is not all-inclusive and includes only common medications that may interact with prednisolone. You should refer to the prescribing information for prednisolone for a complete list of interactions.

References

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use prednisolone only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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