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Klonopin Patient Tips

Medically reviewed on Sep 13, 2018 by C. Fookes, BPharm

How it works

  • Klonopin is a brand (trade) name for clonazepam. Clonazepam may be used in the treatment of certain mood disorders and seizures.
  • Experts aren't sure exactly how Klonopin works to stabilize mood or reduce seizures but experts believe it involves enhancing the activity of GABA (gamma aminobutyric acid) in the brain. This produces a hypnosis (a trancelike state) and decreases abnormal electrical activity.
  • Clonazepam belongs to the class of medicines called benzodiazepines.


  • May be used in the treatment of panic disorder, with or without agoraphobia (fear of places or situations that make you panic).
  • May be used as the sole treatment or in addition to other medications in people with Lennox Gastaut syndrome, myoclonic seizures, or other seizure disorders.
  • May be used to treat absence seizures (petit mal seizures) that have not responded to succinimides (such as ethosuximide).
  • May also be used off-label for some other conditions.
  • The effectiveness of Klonopin long-term has not been established. Long-term use is also associated with dependence.
  • Klonopin is available as a generic under the name of clonazepam.


If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Drowsiness, depression, dizziness, ataxia (the loss of full control of body movements), body aches and pains, palpitations, memory disturbance, increased salivation, headache, sinusitis, and tiredness have all been reported.
  • Clonazepam is potentially addictive and may cause emotional or physical dependence.
  • Withdrawal symptoms (including convulsions, tremor, cramps, vomiting, sweating, or insomnia) may occur with abrupt discontinuation; taper off slowly under a doctor's supervision. Abrupt discontinuation may also precipitate prolonged seizures when used in people with seizure disorders.
  • Drowsiness caused by Klonopin may impair judgment and affect your ability to drive or operate machinery. May also increase the risk of falls. Avoid alcohol.
  • Klonopin, as with similar drugs used in the treatment of epilepsy or depression, can increase the risk of suicidal thoughts or behavior. Monitor mood.
  • Avoid combining Klonopin with opioids such as oxycodone or hydrocodone. Profound sedation, respiratory depression (abnormally slow and shallow breathing), coma, and death may result. May also interact with a number of other drugs including those that induce or inhibit cytochrome 4503A hepatic enzymes.
  • Some studies have shown that up to 30% of people taking Klonopin have shown a loss of anticonvulsant activity within three months of starting Klonopin. An increase in dosage may restore effectiveness.
  • Not suitable for people with significant liver disease or acute narrow-angle glaucoma. Dosage may need to be reduced in people with kidney disease. May not be suitable for those people whose breathing is already compromised, with a history of seizures, or who have porphyria.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

Bottom Line

Klonopin may be used in the treatment of panic disorder and in certain types of seizure disorder. Sedation is the most common side effect and it can cause both physical and psychological dependence.


  • Swallow tablets whole with water.
  • Klonopin is potentially addictive and can cause physical and psychological dependence. Take only as directed by your doctor. Do not increase or decrease the dosage without his or her permission. The smallest effective dose for the shortest possible time should be used. Do not discontinue suddenly without your doctor's advice. When it comes time to discontinue Klonopin, your doctor will talk to you about a tapering schedule.
  • Do not take Klonopin with opioids (be aware that some opioids are contained in over-the-counter cough or cold products). Always talk with your pharmacist or doctor before buying over-the-counter medications to check that they are compatible with Klonopin.
  • Do not drive or operate machinery if Klonopin makes you drowsy or impairs your judgment.
  • Do not drink alcohol while taking Klonopin because this may make side effects such as respiratory depression and sedation worse.
  • If your mood changes or you develop depression, a worsening of depression, or a worsening of seizures, talk with your doctor.
  • Seek immediate medical help if you have difficulty breathing while taking Klonopin.
  • Do not start or discontinue Klonopin during pregnancy without speaking to your provider first.
  • Women should not breastfeed their baby while receiving Klonopin.

Response and Effectiveness

  • Klonopin is quickly absorbed and peak concentrations are reached within 1 to 4 hours. One dose can last up to 24 hours; however, split dosages throughout the day may be preferred.


Klonopin (clonazepam) [Package Insert]. Revised 02/2018. Genentech, Inc.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Klonopin only for the indication prescribed.

Copyright 1996-2018 Revision Date: 2018-09-13 02:43:34

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.