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Zepzelca Side Effects

Generic Name: lurbinectedin

Medically reviewed by Drugs.com. Last updated on July 27, 2020.

Note: This document contains side effect information about lurbinectedin. Some of the dosage forms listed on this page may not apply to the brand name Zepzelca.

For the Consumer

Applies to lurbinectedin: intravenous powder for injection

Warning

Lurbinectedin can increase your risk of bleeding or infection. You will need frequent medical tests.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • easy bruising, unusual bleeding, purple or red spots under your skin;

  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;

  • low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing;

  • signs of sepsis--confusion, fever or chills, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill; or

  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • low blood cell counts;

  • cough, trouble breathing;

  • nausea, vomiting, loss of appetite;

  • increased thirst or urination;

  • diarrhea, constipation;

  • muscle or joint pain;

  • feeling tired; or

  • abnormal blood tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to lurbinectedin: intravenous powder for injection

Hematologic

Very common (10% or more): Leucocytes decreased (79%), lymphocytes decreased (79%), hemoglobin decreased (74%), neutrophils decreased (71%),

neutropenia (41%), platelets decreased (37%), anemia (17%), thrombocytopenia (10%)

Common (1% to 10%): Febrile neutropenia[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (e.g., musculoskeletal pain, back pain, arthralgia, pain in extremity, musculoskeletal chest pain, neck pain, bone pain, myalgia) (33%)[Ref]

Metabolic

Very common (10% or more): Glucose increased (52%), anorexia (33%), albumin decreased (32%), sodium decreased (31%), magnesium decreased (22%)[Ref]

Hepatic

Very common (10% or more): Alanine aminotransferase increased (66%), aspartate aminotransferase increased (26%)

Common (1% to 10%): Grade 3 elevations of ALT and AST, Grade 4 elevations of ALT and AST[Ref]

Respiratory

Very common (10% or more): Dyspnea (31%), cough (e.g., cough, productive cough) (20%), respiratory infection (e.g., upper respiratory tract infection, viral upper respiratory tract infection, respiratory tract infection, bronchitis) (18%), pneumonia (10%), lung infection (10%)

Common (1% to 10%): Pneumonitis[Ref]

Other

Very common (10% or more): Fatigue (77%), pyrexia (13%)[Ref]

General

The most common adverse reactions, including laboratory abnormalities (20% or more) were leukopenia, lymphopenia, fatigue, anemia, neutropenia, increased creatinine, increased alanine aminotransferase, increased glucose, thrombocytopenia, nausea, decreased appetite, musculoskeletal pain, decreased albumin, constipation, dyspnea, decreased sodium, increased aspartate aminotransferase, vomiting, cough, decreased magnesium, and diarrhea.[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (e.g., neuropathy peripheral, neuralgia, paresthesia, peripheral sensory neuropathy, hypoesthesia, hyperesthesia) (11%), headache (10%)

Common (1% to 10%): Dysgeusia[Ref]

Renal

Very common (10% or more): Creatinine increased (69%)[Ref]

Cardiovascular

Very common (10% or more): Chest pain (10%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (37%), constipation (31%), vomiting (22%), diarrhea (20%), abdominal pain (e.g., abdominal pain, abdominal pain upper, abdominal discomfort) (11%)[Ref]

References

1. "Product Information. Zepzelca (lurbinectedin)." Jazz Pharmaceuticals, Palo Alto, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.