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Zaditor Side Effects

Generic Name: ketotifen ophthalmic

Note: This document contains side effect information about ketotifen ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Zaditor.

In Summary

Common side effects of Zaditor include: conjunctival injection, headache, and rhinitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ketotifen ophthalmic: oral syrup, oral tablet

Other dosage forms:

Along with its needed effects, ketotifen ophthalmic (the active ingredient contained in Zaditor) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking ketotifen ophthalmic:

Less common
  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Rare
  • Abdominal or stomach pain
  • blistering, itching, peeling, or redness of skin
  • bloody or cloudy urine
  • clay-colored stools
  • convulsions
  • dark urine
  • difficult, burning, or painful urination
  • dizziness
  • frequent urge to urinate
  • muscle spasm or jerking of all extremities
  • rash
  • sudden loss of consciousness
  • unpleasant breath odor
  • vomiting of blood
  • yellow eyes or skin
Symptoms of overdose

Get emergency help immediately if any of the following symptoms of overdose occur while taking ketotifen ophthalmic:

  • Blurred vision
  • confusion
  • convulsions
  • disorientation
  • dizziness
  • drowsiness (severe)
  • faintness or lightheadedness when getting up from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • hyperexcitability
  • loss of consciousness
  • palpitations
  • sweating
  • unusual tiredness or weakness

Some side effects of ketotifen ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Weight gain
Less common or rare
  • Bloody nose
  • drowsiness
  • dryness of mouth
  • excitation
  • increased appetite
  • irritability
  • nervousness
  • swelling of eyelids
  • unexplained nosebleeds

For Healthcare Professionals

Applies to ketotifen ophthalmic: ophthalmic solution

Ocular

Common (1% to 10%): Irritation, pain, punctate keratitis, punctate corneal epithelial erosion
Uncommon (0.1% to 1%): Blurred vision, dry eye, eyelid disorder, conjunctivitis, photophobia, conjunctival hemorrhage
Postmarketing reports: Swelling, eyelid pruritus, edema[Ref]

Ketotifen instillation was associated with mild to moderate burning or stinging in 98% of patients (n=35) in one trial.[Ref]

Nervous system

Uncommon (0.1% to 1%): Headache, somnolence
Postmarketing reports: Dizziness[Ref]

Respiratory

Postmarketing reports: Exacerbation of asthma[Ref]

General

The most commonly reported adverse effects have included eye irritation, eye pain, punctate keratitis, and punctate corneal epithelial erosion.[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, eczema, urticaria
Postmarketing reports: Contact dermatitis, facial edema, exacerbation of eczema[Ref]

Gastrointestinal

Uncommon (0.1% to 1%): Dry mouth[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity, allergic reactions
Postmarketing reports: Exacerbation of preexisting allergic conditions[Ref]

References

1. Yanni JM, Stephens DJ, Miller ST, Weimer LK, Graff G, Parnell D, Lang LS, Spellman JM, Brady MT, Gamache DA "The in vitro and in vivo ocular pharmacology of olopatadine (AL- 4943A), an effective anti-allergic/antihistaminic agent." J Ocul Pharmacol Ther 12 (1996): 389-400

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Artal MN, Luna JD, Discepola M "A forced choice comfort study of olopatadine hydrochloride 0.1% versus ketotifen fumarate 0.05%." Acta Ophthalmol Scandinavica 78 (2000): 64-5

4. "Product Information. Zaditor (ketotifen ophthalmic)" Ciba Vision Ophthalmics, Duluth, GA.

Some side effects of Zaditor may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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