Xylocaine HCl Side Effects
Generic name: lidocaine
Medically reviewed by Drugs.com. Last updated on Sep 7, 2023.
Note: This document contains side effect information about lidocaine. Some dosage forms listed on this page may not apply to the brand name Xylocaine HCl.
Applies to lidocaine: injection solution. Other dosage forms:
Serious side effects of Xylocaine HCl
Along with its needed effects, lidocaine (the active ingredient contained in Xylocaine HCl) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking lidocaine:
Incidence not known
- Bluish-colored lips, fingernails, or palms blurred or double vision
- chest pain or discomfort
- cold, clammy, pale skin
- continuing ringing or buzzing or other unexplained noise in the ears
- dark urine
- difficulty breathing
- difficulty swallowing
- dizziness or lightheadedness
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast heartbeat
- hearing loss
- hives, itching, skin rash
- irregular heartbeat
- irregular, fast or slow, or shallow breathing
- loss of consciousness
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid or slow heart rate
- slow or irregular heartbeat
- sore throat
- tightness in the chest
- unusual bleeding or bruising
- unusual tiredness or weakness
Other side effects of Xylocaine HCl
Some side effects of lidocaine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Cold or numb feeling
- false or unusual sense of well-being
- feeling of heat
- loss of bladder and bowel control
- loss of genital sensation and sexual function
For Healthcare Professionals
Applies to lidocaine: compounding powder, injectable solution, intravenous solution.
Adverse reactions following administration of this drug are similar in nature to those observed with other amide local anesthetic agents. The most serious adverse reactions tend to be systemic in nature. In general, these adverse reactions are dose-related and may result from high plasma levels caused by excessive dosage, rapid absorption, or inadvertent intravascular injection, or may result from a hypersensitivity, idiosyncrasy, or diminished tolerance on the part of the patient.[Ref]
Frequency not reported: Bradycardia, hypotension, cardiovascular collapse, cardiac arrest, circulatory collapse, hypertension, arrhythmia, maternal hypotension, shock, tachycardia, ventricular fibrillation, heart block, myocardial depression, peripheral vasodilation[Ref]
Frequency not reported: Lightheadedness, headache, dizziness, drowsiness, cold/numbness, tremor, convulsions, unconsciousness, positional headache, peripheral nerve symptoms, spinal cord deficit, paresthesia, speech slurred, arachnoiditis, peripheral nerve injury, coma, paralysis of the lower extremities, cauda equina syndrome, Horner's syndrome, hemiparesis, circumoral paresthesia, nystagmus[Ref]
Frequency not reported: Vomiting, nausea, bowel control loss, swallowing difficult, numbness of tongue[Ref]
Frequency not reported: Nervousness, apprehension, euphoria, confusion, agitation, disorientation, psychosis, restlessness, excitement[Ref]
Frequency not reported: Methemoglobinemia[Ref]
Frequency not reported: Bladder control loss, sexual function loss, perineal sensation loss, urinary retention[Ref]
Frequency not reported: Persistent anesthesia[Ref]
Frequency not reported: Blurred/doubled vision, diplopia, transient amaurosis, bilateral amaurosis[Ref]
Frequency not reported: Tinnitus, feeling hot, edema, shiver, total spinal block, hyperacusis, weakness, sphincter control loss[Ref]
Frequency not reported: Respiratory depression, respiratory arrest, dyspnea, bronchospasm, hypoventilation, apnea, respiratory inadequacy, respiratory failure, yawning[Ref]
More about Xylocaine HCl (lidocaine)
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Related treatment guides
1. Product Information. Xylocaine (lidocaine). Astra-Zeneca Pharmaceuticals. 2002.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
3. Cerner Multum, Inc. Australian Product Information.
4. MHRA. Medicines and Health Regulatory Agency. MHRA Drug Safety Update. http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate 2013.
5. Product Information. Lidocaine Hydrochloride, Injectable (lidocaine). Hospira Inc. 2017.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.