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Xylocaine 10% Oral Side Effects

Generic name: lidocaine topical

Medically reviewed by Last updated on Dec 29, 2023.

Note: This document contains side effect information about lidocaine topical. Some dosage forms listed on this page may not apply to the brand name Xylocaine 10% Oral.

Applies to lidocaine topical: topical application cream, topical application gel/jelly, topical application lotion, topical application ointment, topical application pad, topical application patch extended release, topical application powder, topical application solution, topical application spray, topical application swab.


Topical application route (Solution)

Seizures, cardiopulmonary arrest, and death have been reported in patients under 3-years-old when lidocaine solution 2% was not administered according to dosing and administration recommendations. This drug should not be used for teething pain and only be administered to patients under 3-years-old when absolutely necessary.

Serious side effects of Xylocaine 10% Oral

Along with its needed effects, lidocaine topical (the active ingredient contained in Xylocaine 10% Oral) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lidocaine topical:


Incidence not known

Other side effects of Xylocaine 10% Oral

Some side effects of lidocaine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to lidocaine topical: intradermal device, mucous membrane solution, mucous membrane spray, rectal cream, topical cream, topical film, topical gel, topical gel with applicator, topical kit, topical liquid, topical lotion, topical ointment, topical solution, topical spray, topical stick.


The most common adverse events were administration site reactions: burning, dermatitis, erythema, pruritus, rash, skin irritation, and vesicles.[Ref]


Very common (10% or more): Erythema (up to 67.3%), petechiae (up to 46.4%)

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Skin lesion, skin injury

Frequency not reported: Flushing, cutaneous lesions, urticaria, dermatitis[Ref]


Very common (10% or more): Administration site reactions

Common (1% to 10%): Irritation, redness, itching, application site erythema, application site burning, application site pain, application site pruritus, edema

Uncommon (0.1% to 1%): Venipuncture site hemorrhage, burning sensation

Frequency not reported: Locus of abnormal sensation, paleness (pallor or blanching), alteration in temperature sensation, blisters, bruising, depigmentation, dermatitis, discoloration, exfoliation, papules, petechiae, vesicles, application site dermatitis, application site vesicles, skin irritation[Ref]

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Dizziness

Frequency not reported: Lightheadedness, nervousness, apprehension, euphoria, confusion, drowsiness, tinnitus, nystagmus, headache, nausea, vomiting, sensations of heat, cold or numbness, twitching, tremors, paraesthesia, convulsions, unconsciousness, respiratory depression and arrest, pain and/or dysesthesia in the buttocks or legs, unconsciousness

Postmarketing reports: Headache, hyperesthesia, hypoesthesia, lightheadedness, metallic taste, somnolence, taste alteration[Ref]


Common (1% to 10%): Nausea, vomiting[Ref]


Common (1% to 10%): Nasopharyngitis[Ref]


Very rare (less than 0.01%): Anaphylactic reaction, hypersensitivity

Frequency not reported: Anaphylactoid reactions, anaphylactic shock, angioedema, bronchospasm, shock, dyspnea, laryngospasm[Ref]


Frequency not reported: Bradycardia, hypotension, arrhythmia, cardiovascular collapse, cardiac arrest, AV block, myocardial depression[Ref]


Frequency not reported: Methemoglobinemia[Ref]


Frequency not reported: Corneal irritation, blurred or double vision

Postmarketing reports: Visual disturbances[Ref]


Rare (less than 0.1%): Endotracheal tube occlusion

Frequency not reported: Sore throat, hoarseness, loss of voice[Ref]


Frequency not reported: Confusion, psychosis, disorientation, dizziness[Ref]


Postmarketing reports: Open wound, asthenia, pain exacerbated[Ref]


1. (2001) "Product Information. Lidoderm (lidocaine topical)." Endo Laboratories LLC

2. (2004) "Product Information. LMX 4 (lidocaine topical)." Ferndale Laboratories Inc

3. Cerner Multum, Inc. "UK Summary of Product Characteristics."

4. Cerner Multum, Inc. "Australian Product Information."

5. (2008) "Product Information. Zingo (lidocaine topical)." Sagent Pharmaceuticals, Inc.

6. Gammaitoni AR, Davis MW (2002) "Pharmacokinetics and tolerability of lidocaine patch 5% with extended dosing." Ann Pharmacother, 36, p. 236-40

7. Gammaitoni AR, Alvarez NA, Galer BS (2002) "Pharmacokinetics and safety of continuously applied lidocaine patches 5%." Am J Health Syst Pharm, 59, p. 2215-20

8. "Product Information. Xylocaine Jelly (lidocaine topical)." Astra-Zeneca Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.