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X-Hist Side Effects

Generic Name: carbinoxamine / phenylephrine

Note: This page contains side effects data for the generic drug carbinoxamine / phenylephrine. It is possible that some of the dosage forms included below may not apply to the brand name X-Hist.

For the Consumer

Applies to carbinoxamine / phenylephrine: sustained-release tablets

Other dosage forms:

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; diarrhea; dizziness; drowsiness; dry mouth, throat, or nose; excitability; headache; heartburn; nausea; nervousness; restlessness; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur while taking carbinoxamine / phenylephrine:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; difficulty urinating; double vision; fast or irregular heartbeat; fever; frequent or painful urination; hallucinations; paleness; seizures; severe nervousness, anxiety, or excitability; severe or persistent headache or dizziness; tremor.

For Healthcare Professionals

Applies to carbinoxamine / phenylephrine: oral drops, oral liquid, oral tablet extended release


Cardiovascular side effects have included arrhythmias, increased heart rate, and increased blood pressure.[Ref]

Nervous system

Nervous system side effects have included central nervous system stimulation, tremors, convulsions, nervousness, insomnia, headache, sedation, and dizziness.[Ref]


Gastrointestinal side effects have included dry mouth, nausea, anorexia, heartburn, and diarrhea.[Ref]


Genitourinary side effects have included dysuria and polyuria.[Ref]


Hematologic side effects have included unusual bleeding or bruising, anemia and blood dyscrasias.[Ref]


Psychiatric side effects have included mood or mental changes, hallucinations, and psychotic episodes.[Ref]


Hypersensitivity side effects have included allergic reactions and tightness in the chest.[Ref]


Respiratory side effects have included respiratory difficulty.[Ref]


General side effects have included weakness and pallor.[Ref]


1. "Product Information. Norel LA (carbinoxamine-phenylephrine)." U.S. Pharmaceutical Corporation, Decatur, GA.

It is possible that some side effects of X-Hist may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.