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Venetoclax Side Effects

In Summary

Commonly reported side effects of venetoclax include: tumor lysis syndrome and neutropenia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to venetoclax: oral tablet

Along with its needed effects, venetoclax may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking venetoclax:

More Common

  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • body aches or pain
  • chest pain
  • convulsions
  • decreased urine
  • dry mouth
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • tightness in the chest
  • tingling of the hands or feet
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss

Incidence Not Known

  • Cough
  • ear congestion
  • fever or chills
  • joint pain, stiffness, or swelling
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • runny nose
  • sneezing
  • sore throat
  • stomach pain
  • ulcers, sores, or white spots in the mouth

Some side effects of venetoclax may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

For Healthcare Professionals

Applies to venetoclax: oral kit, oral tablet

Gastrointestinal

Very common (10% or more): Diarrhea (35%), nausea (33%), vomiting (15%), constipation (14%)[Ref]

General

The most common adverse reactions (20% or greater) of any grade were neutropenia, diarrhea, nausea, anemia, upper respiratory tract infection, thrombocytopenia, and fatigue.[Ref]

Hematologic

Very common (10% or more): Neutropenia (45%), anemia (29%), thrombocytopenia (22%)

Common (1% to 10%): Febrile neutropenia

Frequency not reported: Autoimmune hemolytic anemia[Ref]

Metabolic

Very common (10% or more): Hyperkalemia (20%), hyperphosphatemia (15%), hypokalemia (12%)

Common (1% to 10%): Tumor lysis syndrome, hypocalcemia, hyperuricemia[Ref]

Musculoskeletal

Very common (10% or more): Back pain (10%)[Ref]

Nervous system

Very common (10% or more): Headache (15%)[Ref]

Other

Very common (10% or more): Fatigue (21%), pyrexia (16%), peripheral edema (11%)[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (22%), cough (13%)

Common (1% to 10%): Pneumonia[Ref]

References

1. "Product Information. Venclexta (venetoclax)." AbbVie US LLC, North Chicago, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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