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Venclexta Side Effects

Generic Name: venetoclax

Note: This page contains side effects data for the generic drug venetoclax. It is possible that some of the dosage forms included below may not apply to the brand name Venclexta.

For the Consumer

Applies to venetoclax: oral tablet

As well as its needed effects, venetoclax (the active ingredient contained in Venclexta) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking venetoclax, check with your doctor immediately:

More common:
  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • body aches or pain
  • chest pain
  • convulsions
  • decreased urine
  • dry mouth
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • tightness in the chest
  • tingling of the hands or feet
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
Incidence not known:
  • Cough
  • ear congestion
  • fever or chills
  • joint pain, stiffness, or swelling
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • runny nose
  • sneezing
  • sore throat
  • stomach pain
  • ulcers, sores, or white spots in the mouth

Minor Side Effects

Some venetoclax side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Back pain
  • diarrhea
  • difficulty having a bowel movement (stool)
  • nausea or vomiting

For Healthcare Professionals

Applies to venetoclax: oral kit, oral tablet


Very common (10% or more): Diarrhea (35%), nausea (33%), vomiting (15%), constipation (14%)[Ref]


The most common adverse reactions (20% or greater) of any grade were neutropenia, diarrhea, nausea, anemia, upper respiratory tract infection, thrombocytopenia, and fatigue.[Ref]


Very common (10% or more): Neutropenia (45%), anemia (29%), thrombocytopenia (22%)
Common (1% to 10%): Febrile neutropenia
Frequency not reported: Autoimmune hemolytic anemia[Ref]


Very common (10% or more): Hyperkalemia (20%), hyperphosphatemia (15%), hypokalemia (12%)
Common (1% to 10%): Tumor lysis syndrome, hypocalcemia, hyperuricemia[Ref]


Very common (10% or more): Back pain (10%)[Ref]

Nervous system

Very common (10% or more): Headache (15%)[Ref]


Very common (10% or more): Fatigue (21%), pyrexia (16%), peripheral edema (11%)[Ref]


Very common (10% or more): Upper respiratory tract infection (22%), cough (13%)
Common (1% to 10%): Pneumonia


1. "Product Information. Venclexta (venetoclax)." AbbVie US LLC, North Chicago, IL.

It is possible that some side effects of Venclexta may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.