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Velosef Side Effects

Generic Name: cephradine

Note: This page contains side effects data for the generic drug cephradine. It is possible that some of the dosage forms included below may not apply to the brand name Velosef.

For the Consumer

Applies to cephradine: oral capsule

Get emergency medical help if you have any of these signs of an allergic reaction while taking cephradine (the active ingredient contained in Velosef) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;

  • fever, chills, body aches, flu symptoms;

  • tightness in your chest;

  • unusual bleeding;

  • seizure (convulsions);

  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;

  • jaundice (yellowing of the skin or eyes);

  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

  • increased thirst, loss of appetite, swelling, weight gain, feeling short of breath, urinating less than usual or not at all.

Less serious side effects of cephradine may include:

  • nausea, vomiting, stomach pain, mild diarrhea;

  • stiff or tight muscles;

  • joint pain;

  • dizziness;

  • feeling restless or hyperactive;

  • unusual or unpleasant taste in your mouth;

  • mild itching or skin rash; or

  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to cephradine: oral capsule, oral powder for reconstitution


Pseudomembranous colitis has been reported in patients receiving cephradine (the active ingredient contained in Velosef) both orally and intravenously. Diarrhea generally starts 1 to 16 days after starting cephradine therapy. If the diarrhea is unresponsive to discontinuation of the drug and/or standard therapy, a diagnosis of pseudomembranous colitis should be considered.[Ref]

Gastrointestinal side effects have included nausea, vomiting, and diarrhea, and are among the most common side effects associated with cephradine. Several cases of pseudomembranous colitis associated with the use of cephradine have been reported.[Ref]


Hypersensitivity reactions have included rash, urticaria, pruritus, and joint pain.[Ref]


Hematologic side effects have included transient and mild eosinophilia, neutropenia and leukopenia.[Ref]


Hepatic side effects have included transient elevations of SGOT, SGPT, and bilirubin. Hepatocellular damage has not been reported.[Ref]


Renal side effects associated with some cephalosporins have included interstitial nephritis. (Reversible fever, azotemia, pyuria, and eosinophilia are the hallmarks of cephalosporin-induced interstitial nephritis.)[Ref]


Genitourinary side effects have included vaginal yeast infections.[Ref]

Nervous system

Nervous system side effects have included dizziness.[Ref]


Other side effects have included chest tightness.[Ref]


1. Cannon SR, Dyson PH, Sanderson PJ "Pseudomembranous colitis associated with antibiotic prophylaxis in orthopaedic surgery." J Bone Joint Surg Br 70-B (1988): 600-2

2. Sankarankutty M, McGeorge D, Galasko CS "Pseudomembranous colitis following cephradine prophylaxis." Postgrad Med J 58 (1982): 726-8

3. Roberts AP, Hughes AW "Complications with antibiotics used prophylactically in joint replacement surgery." Int Orthop 8 (1985): 299-301

4. Klinger D, Radford P, Collin J "Pneumoperitoneum without faecal peritonitis in a patient with pseudomembranous colitis." Br Med J 288 (1984): 1271-2

5. "Product Information. Velosef (cephradine)." Apothecon Inc, Plainsboro, NJ.

6. Kalb RE, Grossman ME "Pustular eruption following administration of cephradine." Cutis 38 (1986): 58-60

7. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins." Contact Dermatitis 34 (1996): 226

8. Lawson A, McArdle T, Ghosh S "Cephradine-associated immune neutrophenia." N Engl J Med 312 (1985): 651

It is possible that some side effects of Velosef may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.