Cephradine use while Breastfeeding

Drugs containing Cephradine: Velosef

Cephradine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Cephradine is acceptable to use during breastfeeding. Limited information indicates that maternal doses of oral cephradine up to 2 grams daily produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels. Six women were given cephradine 500 mg orally every 6 hours for 9 doses. Milk levels after the last dose were essentially constant for the 6 hours following the dose with a range of 0.62 to 0.68 mg/L.[1][2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Cephalexin

References

1. Mischler TW, Corson SL, Bolognese RJ et al. Presence of cephradine in body fluids of lactating and pregnant women. Clin Pharmacol Ther. 1972;15:214. Abstract.

2. Mischler TW, Corson SL, Larranaga A et al. Cephradine and epicillin in body fluids of lactating and pregnant women. J Reprod Med. 1978;21:130-6. PMID: 569206

Cephradine Identification

Substance Name

Cephradine

CAS Registry Number

38821-53-3

Drug Class

Antiinfective Agents

Antibacterial Agents

Cephalosporins

Administrative Information

LactMed Record Number

61

Last Revision Date

20150310

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