Cephradine use while Breastfeeding
Drugs containing Cephradine: Velosef
Cephradine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Cephradine is acceptable to use during breastfeeding. Limited information indicates that maternal doses of oral cephradine up to 2 grams daily produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.
Drug Levels
Maternal Levels. Six women were given cephradine 500 mg orally every 6 hours for 9 doses. Milk levels after the last dose were essentially constant for the 6 hours following the dose with a range of 0.62 to 0.68 mg/L.[1][2]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
1. Mischler TW, Corson SL, Bolognese RJ et al. Presence of cephradine in body fluids of lactating and pregnant women. Clin Pharmacol Ther. 1972;15:214. Abstract.
2. Mischler TW, Corson SL, Larranaga A et al. Cephradine and epicillin in body fluids of lactating and pregnant women. J Reprod Med. 1978;21:130-6. PMID: 569206
Cephradine Identification
Substance Name
Cephradine
CAS Registry Number
38821-53-3
Drug Class
Antiinfective Agents
Antibacterial Agents
Cephalosporins
Administrative Information
LactMed Record Number
61
Last Revision Date
20150310
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