Limited information indicates cephradine produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. cephradine is acceptable in nursing mothers.
Drug Levels
Maternal Levels. Six women were given cephradine 500 mg orally every 6 hours for 9 doses. Milk levels after the last dose were essentially constant for the 6 hours following the dose with a range of 0.62 to 0.68 mg/L.[1][2]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Mischler TW, Corson SL, Bolognese RJ et al. Presence of cephradine in body fluids of lactating and pregnant women. Clin Pharmacol Ther. 1972;15:214. Abstract.
2.
Mischler TW, Corson SL, Larranaga A et al. Cephradine and epicillin in body fluids of lactating and pregnant women. J Reprod Med. 1978;21:130-6. [PubMed: 569206]
Substance Identification
Substance Name
Cephradine
CAS Registry Number
38821-53-3
Drug Class
Breast Feeding
Lactation
Anti-Infective Agents
Antibacterial Agents
Cephalosporins
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