Cephradine Side Effects
Applies to cephradine: oral capsule, oral powder for reconstitution
Gastrointestinal
Pseudomembranous colitis has been reported in patients receiving cephradine both orally and intravenously. Diarrhea generally starts 1 to 16 days after starting cephradine therapy. If the diarrhea is unresponsive to discontinuation of the drug and/or standard therapy, a diagnosis of pseudomembranous colitis should be considered.[Ref]
Gastrointestinal side effects have included nausea, vomiting, and diarrhea, and are among the most common side effects associated with cephradine. Several cases of pseudomembranous colitis associated with the use of cephradine have been reported.[Ref]
Hypersensitivity
Hypersensitivity reactions have included rash, urticaria, pruritus, and joint pain.[Ref]
Hematologic
Hematologic side effects have included transient and mild eosinophilia, neutropenia and leukopenia.[Ref]
Hepatic
Hepatic side effects have included transient elevations of SGOT, SGPT, and bilirubin. Hepatocellular damage has not been reported.[Ref]
Renal
Renal side effects associated with some cephalosporins have included interstitial nephritis. (Reversible fever, azotemia, pyuria, and eosinophilia are the hallmarks of cephalosporin-induced interstitial nephritis.)[Ref]
Genitourinary
Genitourinary side effects have included vaginal yeast infections.[Ref]
Nervous system
Nervous system side effects have included dizziness.[Ref]
Other
Other side effects have included chest tightness.[Ref]
References
1. Cannon SR, Dyson PH, Sanderson PJ "Pseudomembranous colitis associated with antibiotic prophylaxis in orthopaedic surgery." J Bone Joint Surg Br 70-B (1988): 600-2
2. Sankarankutty M, McGeorge D, Galasko CS "Pseudomembranous colitis following cephradine prophylaxis." Postgrad Med J 58 (1982): 726-8
3. "Product Information. Velosef (cephradine)." Apothecon Inc, Plainsboro, NJ.
4. Roberts AP, Hughes AW "Complications with antibiotics used prophylactically in joint replacement surgery." Int Orthop 8 (1985): 299-301
5. Klinger D, Radford P, Collin J "Pneumoperitoneum without faecal peritonitis in a patient with pseudomembranous colitis." Br Med J 288 (1984): 1271-2
6. Kalb RE, Grossman ME "Pustular eruption following administration of cephradine." Cutis 38 (1986): 58-60
7. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins." Contact Dermatitis 34 (1996): 226
8. Lawson A, McArdle T, Ghosh S "Cephradine-associated immune neutrophenia." N Engl J Med 312 (1985): 651
Some side effects of cephradine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about cephradine
- Side Effects
- During Pregnancy or Breastfeeding
- Drug Images
- Drug Interactions
- Support Group
- 0 Reviews – Add your own review/rating
- Drug class: first generation cephalosporins
Professional resources
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.
