Vabomere Side Effects

Generic name: meropenem / vaborbactam

Medically reviewed by Drugs.com. Last updated on Nov 15, 2024.

Note: This document provides detailed information about Vabomere.

Applies to meropenem / vaborbactam: intravenous powder for solution Side Effects associated with meropenem / vaborbactam. Some dosage forms listed on this page may not apply specifically to the brand name Vabomere.

Applies to meropenem / vaborbactam: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

This medicine may cause a serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using this medicine.

Some patients may develop tremors or seizures while receiving this medicine. If you already have a history of seizures and you are taking medicine for seizures, you should continue unless otherwise directed by your doctor. Tell your doctor if you are taking divalproex sodium (Depakote®) or valproic acid (Depakene®).

Meropenem and vaborbactam combination injection may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop receiving this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

This medicine may cause confusion, headaches, or numbness. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Vabomere

Along with its needed effects, meropenem / vaborbactam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking meropenem / vaborbactam:

Other side effects of Vabomere

Some side effects of meropenem / vaborbactam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to meropenem / vaborbactam: intravenous powder for injection.

General adverse events

The most common side effects were headache, phlebitis/infusion site reactions, infusion site phlebitis, diarrhea, and nausea. This drug was discontinued due to a side effect in 2.9% (8/272) of patients (compared to 5.1% [14/273] of patients using piperacillin-tazobactam); therapy was discontinued most commonly due to hypersensitivity and infusion-related reactions. Death occurred in 0.7% of patients using this drug and in 0.7% of patients using piperacillin-tazobactam.^[Ref]

Nervous system

• Common (1% to 10%): Headache
• Uncommon (0.1% to 1%): Dizziness, tremor, paresthesia, lethargy

Meropenem:

• Rare (0.01% to 0.1%): Convulsions^[Ref]

Local

• Common (1% to 10%): Phlebitis/infusion site reactions (included infusion/injection site phlebitis, infusion site thrombosis, infusion site erythema), infusion site phlebitis
• Uncommon (0.1% to 1%): Infusion site erythema, injection site phlebitis, infusion site thrombosis, infusion related reaction^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea, nausea, vomiting
• Uncommon (0.1% to 1%): Abdominal distension, Clostridioides difficile colitis, oral candidiasis
• Frequency not reported: C difficile-associated diarrhea

Meropenem:

• Uncommon (0.1% to 1%): Abdominal pain^[Ref]

Hypersensitivity

• Common (1% to 10%): Hypersensitivity (included hypersensitivity, drug hypersensitivity, anaphylactic reaction, rash, urticaria, bronchospasm)
• Uncommon (0.1% to 1%): Anaphylactic reaction^[Ref]

Hepatic

• Common (1% to 10%): Increased ALT, increased AST

Meropenem:

• Uncommon (0.1% to 1%): Increased blood bilirubin
• Frequency not reported: Jaundice^[Ref]

Other

• Common (1% to 10%): Pyrexia
• Uncommon (0.1% to 1%): Chest discomfort

Meropenem:

• Common (1% to 10%): Increased blood alkaline phosphatase, increased blood LDH
• Uncommon (0.1% to 1%): Pain^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia, hypoglycemia
• Uncommon (0.1% to 1%): Decreased appetite, hyperkalemia, hyperglycemia^[Ref]

Cardiovascular

• Common (1% to 10%): Hypotension
• Uncommon (0.1% to 1%): Vascular pain
• Frequency not reported: Deep vein thrombosis^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash, urticaria

Meropenem:

• Uncommon (0.1% to 1%): Pruritus
• Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, erythema multiforme, angioedema^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Leukopenia

Meropenem:

• Common (1% to 10%): Thrombocytosis/thrombocythemia
• Uncommon (0.1% to 1%): Neutropenia, eosinophilia, thrombocytopenia
• Frequency not reported: Decreased blood thromboplastin, decreased prothrombin time
• Postmarketing reports: Agranulocytosis, hemolytic anemia, positive direct and indirect Coombs test^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Increased blood creatine phosphokinase^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Hallucination, insomnia^[Ref]

Renal

• Uncommon (0.1% to 1%): Renal impairment
• Frequency not reported: Azotemia

Meropenem:

• Uncommon (0.1% to 1%): Increased blood creatinine, increased blood urea^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Bronchospasm
• Frequency not reported: Pharyngitis^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Vulvovaginal candidiasis, incontinence^[Ref]

See also:

Frequently asked questions

• What drugs are contained in Vabomere?

Further information

Vabomere side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer