Vabomere Side Effects

Generic name: meropenem / vaborbactam

Medically reviewed by Drugs.com. Last updated on Nov 24, 2024.

Note: This document provides detailed information about Vabomere Side Effects associated with meropenem / vaborbactam. Some dosage forms listed on this page may not apply specifically to the brand name Vabomere.

Applies to meropenem / vaborbactam: intravenous powder for solution.

Serious side effects of Vabomere

Along with its needed effects, meropenem / vaborbactam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking meropenem / vaborbactam:

Less common side effects

• bluish color
• changes in skin color
• decreased urine
• diarrhea
• dry mouth
• increased thirst
• irregular heartbeat
• loss of appetite
• mood changes
• muscle pain or cramps
• nausea
• numbness or tingling in the hands, feet, or lips
• seizures
• swelling of the foot or leg
• unusual tiredness or weakness
• vomiting

Rare side effects

• anxiety
• black, tarry stools
• bloody or cloudy urine
• blurred vision
• body aches or pain
• chest discomfort
• chest pain
• chills
• cold sweats
• confusion
• cool, pale skin
• cough
• depression
• difficulty breathing
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dryness or soreness of the throat
• fast heartbeat
• fever
• flushed, dry skin
• fruit-like breath odor
• headache
• hoarseness
• increased hunger
• increased urination
• itching of the vagina or genitals
• loss of consciousness
• nervousness
• nightmares
• pain in the lower back or side
• pain, redness, or swelling in the arm or leg
• painful or difficult urination
• runny nose
• seeing, hearing, or feeling things that are not there
• shakiness
• slurred speech
• sore mouth, throat, or tongue
• sores, ulcers, or white spots on the lips or in the mouth
• stomach pain
• sweating
• tender, swollen glands in the neck
• thick, white vaginal discharge with mild or no odor
• trouble in swallowing
• unexplained weight loss
• unusual bleeding or bruising
• voice changes
• weakness or heaviness of the legs

Other side effects of Vabomere

Some side effects of meropenem / vaborbactam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• decreased appetite

For healthcare professionals

Applies to meropenem / vaborbactam: intravenous powder for injection.

General adverse events

The most common side effects were headache, phlebitis/infusion site reactions, infusion site phlebitis, diarrhea, and nausea. This drug was discontinued due to a side effect in 2.9% (8/272) of patients (compared to 5.1% [14/273] of patients using piperacillin-tazobactam); therapy was discontinued most commonly due to hypersensitivity and infusion-related reactions. Death occurred in 0.7% of patients using this drug and in 0.7% of patients using piperacillin-tazobactam.^[Ref]

Nervous system

• Common (1% to 10%): Headache
• Uncommon (0.1% to 1%): Dizziness, tremor, paresthesia, lethargy

Meropenem:

• Rare (0.01% to 0.1%): Convulsions^[Ref]

Local

• Common (1% to 10%): Phlebitis/infusion site reactions (included infusion/injection site phlebitis, infusion site thrombosis, infusion site erythema), infusion site phlebitis
• Uncommon (0.1% to 1%): Infusion site erythema, injection site phlebitis, infusion site thrombosis, infusion related reaction^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea, nausea, vomiting
• Uncommon (0.1% to 1%): Abdominal distension, Clostridioides difficile colitis, oral candidiasis
• Frequency not reported: C difficile-associated diarrhea

Meropenem:

• Uncommon (0.1% to 1%): Abdominal pain^[Ref]

Hypersensitivity

• Common (1% to 10%): Hypersensitivity (included hypersensitivity, drug hypersensitivity, anaphylactic reaction, rash, urticaria, bronchospasm)
• Uncommon (0.1% to 1%): Anaphylactic reaction^[Ref]

Hepatic

• Common (1% to 10%): Increased ALT, increased AST

Meropenem:

• Uncommon (0.1% to 1%): Increased blood bilirubin
• Frequency not reported: Jaundice^[Ref]

Other

• Common (1% to 10%): Pyrexia
• Uncommon (0.1% to 1%): Chest discomfort

Meropenem:

• Common (1% to 10%): Increased blood alkaline phosphatase, increased blood LDH
• Uncommon (0.1% to 1%): Pain^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia, hypoglycemia
• Uncommon (0.1% to 1%): Decreased appetite, hyperkalemia, hyperglycemia^[Ref]

Cardiovascular

• Common (1% to 10%): Hypotension
• Uncommon (0.1% to 1%): Vascular pain
• Frequency not reported: Deep vein thrombosis^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash, urticaria

Meropenem:

• Uncommon (0.1% to 1%): Pruritus
• Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, erythema multiforme, angioedema^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Leukopenia

Meropenem:

• Common (1% to 10%): Thrombocytosis/thrombocythemia
• Uncommon (0.1% to 1%): Neutropenia, eosinophilia, thrombocytopenia
• Frequency not reported: Decreased blood thromboplastin, decreased prothrombin time
• Postmarketing reports: Agranulocytosis, hemolytic anemia, positive direct and indirect Coombs test^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Increased blood creatine phosphokinase^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Hallucination, insomnia^[Ref]

Renal

• Uncommon (0.1% to 1%): Renal impairment
• Frequency not reported: Azotemia

Meropenem:

• Uncommon (0.1% to 1%): Increased blood creatinine, increased blood urea^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Bronchospasm
• Frequency not reported: Pharyngitis^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Vulvovaginal candidiasis, incontinence^[Ref]

Frequently asked questions

• What drugs are contained in Vabomere?

Further information

Vabomere side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer