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Vabomere Side Effects

Generic Name: meropenem / vaborbactam

Note: This document contains side effect information about meropenem / vaborbactam. Some of the dosage forms listed on this page may not apply to the brand name Vabomere.

For the Consumer

Applies to meropenem / vaborbactam: intravenous powder for solution

Along with its needed effects, meropenem/vaborbactam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking meropenem / vaborbactam:

Less common
  • Bluish color
  • changes in skin color
  • decreased urine
  • diarrhea
  • dry mouth
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea
  • numbness or tingling in the hands, feet, or lips
  • seizures
  • swelling of the foot or leg
  • unusual tiredness or weakness
  • vomiting
  • Anxiety
  • black, tarry stools
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • chest discomfort
  • chest pain
  • chills
  • cold sweats
  • confusion
  • cool, pale skin
  • cough
  • depression
  • difficulty breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dryness or soreness of the throat
  • fast heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • hoarseness
  • increased hunger
  • increased urination
  • itching of the vagina or genitals
  • loss of consciousness
  • nervousness
  • nightmares
  • pain in the lower back or side
  • pain, redness, or swelling in the arm or leg
  • painful or difficult urination
  • runny nose
  • seeing, hearing, or feeling things that are not there
  • shakiness
  • slurred speech
  • sore mouth, throat, or tongue
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain
  • sweating
  • tender, swollen glands in the neck
  • thick, white vaginal discharge with mild or no odor
  • trouble in swallowing
  • unexplained weight loss
  • unusual bleeding or bruising
  • voice changes
  • weakness or heaviness of the legs

Some side effects of meropenem / vaborbactam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • decreased appetite

For Healthcare Professionals

Applies to meropenem / vaborbactam: intravenous powder for injection


The most common side effects were headache, phlebitis/infusion site reactions, and diarrhea. This drug was discontinued due to a side effect in 2.9% (8/272) of patients (compared to 5.1% [14/273] of patients using piperacillin-tazobactam); therapy was discontinued most commonly due to hypersensitivity and infusion-related reactions. Death occurred in 0.7% of patients using this drug and in 0.7% of patients using piperacillin-tazobactam.[Ref]

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Dizziness, tremor, paresthesia, lethargy

-Frequency not reported: Convulsions[Ref]


Common (1% to 10%): Phlebitis/infusion site reactions (included infusion/injection site phlebitis, infusion site thrombosis, infusion site erythema)[Ref]


Common (1% to 10%): Diarrhea, nausea
Frequency not reported: Oral candidiasis

-Frequency not reported: Abdominal pain[Ref]


Common (1% to 10%): Hypersensitivity (included hypersensitivity, drug hypersensitivity, anaphylactic reaction, rash, urticaria, bronchospasm)[Ref]


Common (1% to 10%): Increased ALT, increased AST

-Frequency not reported: Jaundice, increased blood bilirubin[Ref]


Common (1% to 10%): Pyrexia
Frequency not reported: Chest discomfort

-Frequency not reported: Increased blood alkaline phosphatase, increased blood LDH, pain[Ref]


Common (1% to 10%): Hypokalemia
Frequency not reported: Decreased appetite, hyperkalemia, hyperglycemia, hypoglycemia[Ref]


Frequency not reported: Deep vein thrombosis, hypotension, vascular pain[Ref]


Frequency not reported: Leukopenia

-Frequency not reported: Thrombocytosis, neutropenia, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia, decreased blood thromboplastin, decreased prothrombin time, positive direct and indirect Coombs test[Ref]


Frequency not reported: Increased creatine phosphokinase[Ref]


Frequency not reported: Hallucination, insomnia[Ref]


Frequency not reported: Azotemia, renal impairment

-Frequency not reported: Increased blood creatinine, increased blood urea[Ref]


Frequency not reported: Vulvovaginal candidiasis[Ref]


Frequency not reported: Pharyngitis[Ref]


-Frequency not reported: Pruritus, toxic epidermal necrolysis, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, erythema multiforme, angioedema[Ref]


1. "Product Information. Vabomere (meropenem-vaborbactam)." The Medicines Company, Parsippany, NJ.

Some side effects of Vabomere may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.