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meropenem and vaborbactam

Generic Name: meropenem and vaborbactam (MER oh PEN em and VA bor BAK tam)
Brand Name: Vabomere

What is meropenem and vaborbactam?

Meropenem and vaborbactam are antibiotics that fight bacteria.

Meropenem and vaborbactam is used to treat serious urinary tract infections in adults.

Meropenem and vaborbactam may also be used for purposes not listed in this medication guide.

What is the most important information I should know about meropenem and vaborbactam?

Before you receive this medicine, tell your doctor if you have a history of allergies to any antibiotic medications.

What should I discuss with my healthcare provider before using meropenem and vaborbactam?

You may not be able to use this medicine if you have ever had an allergic reaction to any antibiotics, including:

  • meropenem or vaborbactam;

  • amoxicillin, ampicillin, Augmentin, Timentin, Unasyn, Zosyn;

  • dicloxacillin, nafcillin, oxacillin, ticarcillin; or

  • any penicillin antibiotic.

To make sure meropenem and vaborbactam is safe for you, tell your doctor if you have ever had:

  • an allergy to a cephalosporin antibiotic (cephalexin, cefdinir, Keflex, Omnicef, and others);

  • a head injury or brain tumor;

  • epilepsy or other seizure disorder; or

  • kidney disease (or if you are on dialysis).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

Meropenem and vaborbactam can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.

How is meropenem and vaborbactam given?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Meropenem and vaborbactam is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Meropenem and vaborbactam is usually given every 8 to 12 hours for up to 14 days. This medicine must be given slowly, and the infusion can take about 3 hours to complete.

Meropenem and vaborbactam is a powder medicine that must be mixed with a liquid (diluent), and then further diluted before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

The diluted mixture must be used within 4 hours if you keep it at room temperature. If you store the IV bag in a refrigerator, use it within 22 hours. Do not freeze.

Each single-use vial (bottle) of meropenem and vaborbactam powder is for one use only. Throw it away after one use, even if there is still medicine left inside.

Do not mix other injectable medications in the same IV bag or tubing used to given your meropenem and vaborbactam injection.

Throw away any unused medicine left in the IV bag after your infusion. Do not not save it for later use.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Meropenem and vaborbactam will not treat a viral infection such as the common cold or flu.

Your kidney function may need to be checked while you are using this medicine.

Store unmixed powder at room temperature away from moisture and heat.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using meropenem and vaborbactam?

This medicine can cause confusion, headaches, or other side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Meropenem and vaborbactam side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • a seizure (convulsions);

  • sores or white patches in your mouth or throat (yeast infection or "thrush");

  • severe tingling or numbness; or

  • unusual bleeding or bruising.

Common side effects may include:

  • headache;

  • diarrhea; or

  • swelling or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side Effects (complete list)

Meropenem and vaborbactam dosing information

Usual Adult Dose for Pyelonephritis:

4 g IV every 8 hours
Duration of therapy: Up to 14 days

Use: For the treatment of patients with complicated urinary tract infections (including pyelonephritis) due to susceptible Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae species complex

Usual Adult Dose for Urinary Tract Infection:

4 g IV every 8 hours
Duration of therapy: Up to 14 days

Use: For the treatment of patients with complicated urinary tract infections (including pyelonephritis) due to susceptible Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae species complex

What other drugs will affect meropenem and vaborbactam?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • divalproex sodium;

  • probenecid; or

  • valproic acid.

This list is not complete. Other drugs may interact with meropenem and vaborbactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about meropenem and vaborbactam.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.01.

Last reviewed: November 13, 2017
Date modified: December 03, 2017

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